Scopus
YÖKSİS Eşleşti
Evaluation of Boron’s Adjuvant Activity in Inactive Bacterin Vaccines Using the Mice Model
Biological Trace Element Research · Mart 2021
YÖKSİS Kayıtları
Evaluation of Borons Adjuvant Activity in Inactive Bacterin Vaccines Using the Mice Model
Biological Trace Element Research · 2021 SCI-Expanded
PROFESÖR ÖZGÜR ÖZDEMİR →
Evaluation of Boron's Adjuvant Activity in Inactive Bacterin Vaccines Using the Mice Model
BIOLOGICAL TRACE ELEMENT RESEARCH · 2021 SCI-Expanded
PROFESÖR ZAFER SAYIN →
Evaluation of Boron's Adjuvant Activity in Inactive Bacterin Vaccines Using the Mice Model
Biological Trace Element Research · 2021 SCI-Expanded
PROFESÖR OSMAN ERGANİŞ →
Evaluation of Boron\u2019s Adjuvant Activity in Inactive Bacterin Vaccines Using the Mice Model
Biological Trace Element Research · 2021 SCI-Expanded
PROFESÖR UÇKUN SAİT UÇAN →
Makale Bilgileri
DergiBiological Trace Element Research
Yayın TarihiMart 2021
Cilt / Sayfa199 · 1037-1043
Scopus ID2-s2.0-85086734846
Özet
Vaccination is the most effective, reliable, and economical way of preventing or reducing the effect of infectious diseases. When preparing inactive vaccines, a range of additives called adjuvants are necessary to enhance the magnitude of the immune response. Boron has a wide range of industrial and medical applications, and its positive effects on distinct functions have been described in plants, humans, and animals. However, no studies exist about the possible adjuvant activities of boron compounds in vaccines. Hence, in this study, the potential adjuvant effect of boric acid was explored and compared with common veterinary adjuvants in a mice model. Staphylococcus aureus (S. aureus) used as vaccine antigen was isolated from dairy cows with bovine mastitis. Vaccines adjuvanted with boric acid, aluminum hydroxide, Montanide ISA 50 and ISA 206, and Montanide + boric acid combinations were prepared. The efficacy of vaccines was evaluated according to local reactions at the injection site, C-reactive protein, total Ig G, total Ig M, and anti-S. aureus antibody levels in mice. Boric acid reduced local inflammatory reactions induced by the Montanide adjuvants. Moreover, mice vaccinated with boric acid-adjuvanted vaccine had higher levels of anti-S. aureus antibody than those in the controls (P < 0.05) and were similar to the levels found in mice sensitized with aluminum hydroxide. Total Ig G and Ig M results were, however, unsuitable for the assessment of adjuvant activity for this study. In conclusion, this study revealed that boric acid has an adjuvant potential in inactive bacterin vaccines, but further target animal studies are needed.
Yazarlar (8)
1
Zafer Sayın
2
Ali Uslu
3
O. Erganiş
4
Abdullah Başoğlu
5
O. Ozdemir
6
Aslı Sakmanoğlu
7
Uçkun Sait Uçan
8
Zeki Aras
Anahtar Kelimeler
Adjuvant
Aluminum hydroxide
Boric acid
Montanide ISA 206
Montanide ISA 50
Vaccine
Kurumlar
Aksaray Üniversitesi
Aksaray Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
2
Atıf
8
Yazar
6
Anahtar Kelime