Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Determining the protective effect of a boron adjuvanted vaccine with an experimental infection model in mice
Turkish Journal of Veterinary and Animal Sciences · Ocak 2023
YÖKSİS Kayıtları
Determining the protective effect of a boron adjuvanted vaccine with an experimental infection model in mice
Turkish Journal of Veterinary and Animal Sciences · 2023 scopus, cabi, Google scholar, sci, zoological record
PROFESÖR ÖZGÜR ÖZDEMİR →
Determining the protective effect of a boron adjuvanted vaccine with an experimental infection model in mice
The Scientific and Technological Research Council of Turkey (TUBITAK-ULAKBIM) - DIGITAL COMMONS JOURNALS · 2023 SSCI
PROFESÖR UÇKUN SAİT UÇAN →
Determining the protective effect of a boron adjuvanted vaccine with an experimental infection model in mice
TURKISH JOURNAL OF VETERINARY & ANIMAL SCIENCES · 2023 SCI-Expanded
DOÇENT ALİ USLU →
Determining the protective effect of a boron adjuvanted vaccine with an experimental infection model in mice
Turkish Journal of Veterinary and Animal Sciences · 2023 SCI-Expanded
DOÇENT ASLI BALEVİ →
Determining the protective effect of a boron adjuvanted vaccine with an experimental infection model in mice
TURKISH JOURNAL OF VETERINARY & ANIMAL SCIENCES · 2023 SCI-Expanded
PROFESÖR ZAFER SAYIN →
Determining the protective effect of a boron adjuvanted vaccine with an experimental infection model in mice
TURKISH JOURNAL OF VETERINARY & ANIMAL SCIENCES · 2023 SCI-Expanded
PROFESÖR OSMAN ERGANİŞ →
Makale Bilgileri
DergiTurkish Journal of Veterinary and Animal Sciences
Yayın TarihiOcak 2023
Cilt / Sayfa47 · 446-456
Scopus ID2-s2.0-85175876903
Erişim🔓 Açık Erişim
Özet
Boron is a required trace element for plants, humans, and animals and it has significant influence over biological functions and the immune system. Vaccines have aided humans in the control of many contagious diseases around the world. The success of global immunization campaigns may be possible with the development of effective and low-cost vaccines and adjuvants. For this reason, the present study aimed to determine the adjuvant activity of easily accessible boron compounds. In this study, six different vaccines were prepared, including inactive Staphylococcus aureus bacteria, boric acid, aluminum hydroxide, montanide ISA 50, and ISA 206, ISA 50 + boric acid, and ISA 206 + boric acid combinations. The rate of survival following the challenge, the bacterial load on internal organs, and histopathological findings at the vaccine injection site and in the internal organs were evaluated in vaccinated mice. In addition, the levels of interferon - γ and tumor necrosis factor - α were measured in the vaccinated seropotency groups. The rate of postchallenge mortality was 50% in the control group, and no mortality was encountered in the boric acid group. The boric acid adjuvanted vaccine decreased the bacterial load and postchallenge abscess in the internal organs and also local inflammatory reactions due to montanide adjuvants in combinations. No difference was found in the interferon - γ and tumor necrosis factor - α levels between the control and vaccine groups. It was concluded that boric acid can be used as an adjuvant in inactivated vaccines.
Yazarlar (8)
1
Zafer Sayın
2
Ali Uslu
3
O. Ozdemir
4
Abdullah Başoğlu
5
Aslı Balevı
6
Uçkun Sait Uçan
7
Zeki Aras
8
O. Erganiş
Anahtar Kelimeler
Adjuvant
aluminum hydroxide
boron
challenge
vaccine
Kurumlar
Aksaray Üniversitesi
Aksaray Turkey
Selçuk Üniversitesi
Selçuklu Turkey