Scopus
🔓 Açık Erişim
Assessment of therapeutic effect of human choriogonadotropin in a chemical cystitis model
Kaohsiung Journal of Medical Sciences · Mayıs 2017
Makale Bilgileri
DergiKaohsiung Journal of Medical Sciences
Yayın TarihiMayıs 2017
Cilt / Sayfa33 · 229-235
Scopus ID2-s2.0-85016025400
Erişim🔓 Açık Erişim
Özet
In this study, female rats induced with chemical cystitis were administered the hormone human choriogonadotropin (HCG), and it was aimed to reveal the usefulness of HCG in the treatment of interstitial cystitis/bladder pain syndrome. The materials for this study were 32 Wistar albino female rats. The study groups were formed as follows: the cystitis group (Group 1), the cystitis + HCG protection group (Group 2), the cystitis + HCG treatment group (Group 3), and the control group (Group 4), with eight rats in each group. In this study, blood and urine samples were taken from the rats, they were euthanized, and their bladders were removed for glutathione, malondialdehyde, tumor necrosis factor alpha, and interferon gamma measurements. It was observed that tissue damage in Group 2 was lower than that in the other two groups. Glutathione levels in Groups 2 and 4 were significantly higher than in Groups 1 and 3 (p = 0.01). Malondialdehyde levels of Groups 2 and 4 were significantly lower than the values in Groups 1 and 3 (p < 0.001). When the cystitis groups were compared in terms of their interferon gamma and tumor necrosis factor alpha levels, the lowest interferon gamma and tumor necrosis factor alpha levels were detected in Group 3. It was found that HCG has positive effects on experimental cystitis in rats. This study revealed that HCG should be researched as a therapeutic agent and formed a step for studies to be carried out on this subject.
Yazarlar (10)
1
Serhat Tanik
2
Kürsad Zengin
3
Sebahattin Albayrak
4
Abdullah Gurel
5
Muhittin Atar
6
Sevinc Sahin
7
Nevin Tuzcu
ORCID: 0000-0001-5899-3955
8
Mehmet Tuzcu
9
Muhammet Abdurrahim Imamoglu
10
Mesut Gurdal
Anahtar Kelimeler
Bladder pain syndrome
Cyclophosphamide
Human choriogonadotropin
Interstitial cystitis
Rat
Kurumlar
Afyon Kocatepe Üniversitesi
Afyonkarahisar Turkey
Bozok Üniversitesi
Yozgat Turkey
Cumhuriyet Üniversitesi
Sivas Turkey