Scopus
YÖKSİS Eşleşti
Follicle-stimulating hormone receptor gene polymorphisms in women with endometriosis
Archives of Gynecology and Obstetrics · Haziran 2015
YÖKSİS Kayıtları
Follicle-stimulating hormone receptor gene polymorphisms in women with endometriosis
Archives of Gynecology and Obstetrics · 2015 SCI-Expanded
PROFESÖR ÇETİN ÇELİK →
Follicle stimulating hormone receptor gene polymorphisms in women with endometriosis
Archives of Gynecology and Obstetrics · 2015 SCI-Expanded
PROFESÖR ÇETİN ÇELİK →
Follicle stimulating hormone receptor gene polymorphisms in women with endometriosis
Archives of Gynecology and Obstetrics · 2015 SCI-Expanded
PROFESÖR ÇETİN ÇELİK →
Follicle stimulating hormone receptor gene polymorphisms in women with endometriosis
Archives of Gynecology and Obstetrics · 2015 SCI-Expanded
PROFESÖR ÇETİN ÇELİK →
Follicle stimulating hormone receptor gene polymorphisms in women with endometriosis
Archives of Gynecology and Obstetrics · 2015 SCI-Expanded
ÖĞRETİM GÖREVLİSİ SÜLEYMAN NERGİZ →
Follicle stimulating hormone receptor gene polymorphisms in women with endometriosis
Arch Gynecol Obstet · 2015 AHCI
PROFESÖR HASAN ACAR →
Follicle stimulating hormone receptor gene polymorphisms in women with endometriosis
Archives of Gynecology and Obstetrics · 2015 SCI-Expanded
PROFESÖR AYBİKE PEKİN →
Follicle stimulating hormone receptor gene polymorphisms in women with endometriosis
Archives of Gynecology and Obstetrics · 2015 SCI-Expanded
PROFESÖR SETENAY ARZU YILMAZ →
Makale Bilgileri
DergiArchives of Gynecology and Obstetrics
Yayın TarihiHaziran 2015
Cilt / Sayfa291 · 1411-1416
Scopus ID2-s2.0-84939942782
Özet
Objectives: The purpose of this study was to evaluate the influence of the follicle-stimulating hormone (FSH) receptor poymorphisms Asn680Ser and Thr307Ala on endometriosis in Turkish women. Methods: Polymorphic analysis of the FSH receptor gene was performed in 100 patients with endometriosis and 100 controls. Genomic DNA was obtained from peripheral blood leukocytes and polymorphisms were investigated using restriction fragment length polymorphism analysis. Results: There were no significant differences in genotype frequencies of FSH receptor gene between endometriosis patients and controls. When the patients were divided into two groups according to disease severity, we found that the patients with the SS (680 Ser/Ser) or AA (307 Ala/Ala) genotype were less likely to develop stage 3–4 endometriosis compared to the stage 1–2 endometriosis group (P = 0.004; OR: 0.177, 95 % CI 0.055–0.568 and P = 0.040; OR: 0.240, 95 % CI 0.061–0.938; respectively). Conclusions: The distributions of FSHR polymorphisms may not have an effect on endometriosis development but they are associated with the severity of the disease. The polymorphisms encoding SS at the position 680 and AA at the position 307 and the patients with the genotype that included alanine or serine were less likely to develop stage 3–4 endometriosis compared to the stage 1–2 endometriosis group.
Yazarlar (8)
1
Özlem Seçilmiş Kerimoğlu
ORCID: 0000-0003-2208-8712
2
Setenay Arzu Yilmaz
3
Aybike Pekin
4
Süleyman Nergiz
5
F. N. Incesu
6
N. U. Doğan
7
Hasan Acar
8
Çetin Çelik
ORCID: 0000-0001-6165-5092
Anahtar Kelimeler
Endometriosis
Follicle-stimulating hormone receptor
Polymorphism
Restriction fragment length polymorphism analysis
Kurumlar
Akdeniz Üniversitesi
Antalya Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
9
Atıf
8
Yazar
4
Anahtar Kelime