Scopus
YÖKSİS DOI Eşleşti
SJR Q3
The role of human epididymis secretory protein E4 in patients with endometrial cancer and premalignant endometrial lesions
Journal of Obstetrics and Gynaecology · Ocak 2017
YÖKSİS Kayıtları
The role of human epididymis secretory protein E4 in patients with endometrial cancer and premalignant endometrial lesions
Journal of Obstetrics and Gynaecology · 2017 SCI-Expanded
Prof. Dr. ALİ ÜNLÜ →
The role of human epididymis secretory protein E4 in patients with endometrial cancer and premalignant endometrial lesions
Journal of Obstetrics and Gynaecology · 2017 SCI-Expanded
Prof. Dr. AYBİKE PEKİN →
The role of human epididymis secretory protein E4 in patients with endometrial cancer and premalignant endometrial lesions
Journal of Obstetrics and Gynaecology · 2017 SCI-Expanded
Prof. Dr. SETENAY ARZU YILMAZ →
The role of human epididymis secretory protein E4 in patients with endometrial cancer and premalignant endometrial lesions
Journal of Obstetrics and Gynaecology · 2016 SCI-Expanded
Prof. Dr. ÇETİN ÇELİK →
The role of human epididymis secretory protein E4 in patients with endometrial cancer and premalignant endometrial lesions
Journal of Obstetrics and Gynaecology · 2017 SCI-Expanded
Prof. Dr. ÇETİN ÇELİK →
The role of human epididymis secretory protein E4 in patients with endometrial cancer and premalignant endometrial lesions
Journal of Obstetrics and Gynaecology · 2016 SCI-Expanded
Prof. Dr. ALİ ÜNLÜ →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Effect of drainage on postoperative pain after laparoscopic ovarian cystectomy
2015 ISSN: 0144-3615 SCI-Expanded
Prof. Dr. ÇETİN ÇELİK →
Gum chewing reduces the time to first defaecation after pelvic surgery A randomised controlled study
2015 ISSN: 0144-3615 SCI-Expanded
Prof. Dr. ÇETİN ÇELİK →
Evaluation of cervical involvement in endometrial cancer by transvaginal sonography magnetic resonance imaging and frozen section
2010 ISSN: 0144-3615 SCI-Expanded 4 atıf
Prof. Dr. AYBİKE PEKİN →
Effect of drainage on postoperative pain after laparoscopic ovarian cystectomy
2015 ISSN: 0144-3615 SCI-Expanded
Prof. Dr. SETENAY ARZU YILMAZ →
Anti Müllerian hormone is associated with extrauterine involvement and stage of disease in patients with endometrial cancer
2015 ISSN: 0144-3615 SCI-Expanded
Prof. Dr. SETENAY ARZU YILMAZ →
Expression of cyclin A cyclin E and p27 in normal hyperplastic and frankly malignant endometrial samples
2013 ISSN: 0144-3615 SCI-Expanded 1 atıf
Prof. Dr. ÇETİN ÇELİK →
Anti Müllerian hormone is associated with extrauterine involvement and stage of disease in patients with endometrial cancer
2015 ISSN: 0144-3615 SCI-Expanded
Prof. Dr. ÇETİN ÇELİK →
Anti Müllerian hormone is associated with extrauterine involvement and stage of disease in patients with endometrial cancer
2015 ISSN: 0144-3615 SCI-Expanded
Prof. Dr. ÇETİN ÇELİK →
Effect of drainage on postoperative pain after laparoscopic ovarian cystectomy
2015 ISSN: 0144-3615 SCI-Expanded
Prof. Dr. ÇETİN ÇELİK →
Anti Müllerian hormone is associated with extrauterine involvement and stage of disease in patients with endometrial cancer
2015 ISSN: 0144-3615 SCI-Expanded
Prof. Dr. ÇETİN ÇELİK →
Gum chewing reduces the time to first defaecation after pelvic surgery A randomised controlled study
2015 ISSN: 0144-3615 SCI-Expanded
Prof. Dr. ÇETİN ÇELİK →
Assessment of body composition with bioelectrical impedance analysis in pregnant women with hyperemesis gravidarum before and after treatment
2014 ISSN: 0144-3615 SCI-Expanded
Prof. Dr. ÇETİN ÇELİK →
Assessment of body composition with bioelectrical impedance analysis in pregnant women with hyperemesis gravidarum before and after treatment
2015 ISSN: 0144-3615 SCI-Expanded
Prof. Dr. ÇETİN ÇELİK →
Gum chewing reduces the time to first defaecation after pelvic surgery A randomised controlled study
2014 ISSN: 0144-3615 SCI-Expanded
Prof. Dr. ÇETİN ÇELİK →
Assessment of body composition with bioelectrical impedance analysis in pregnant women with hyperemesis gravidarum before and after treatment
2015 ISSN: 0144-3615 SCI-Expanded
Prof. Dr. ÇETİN ÇELİK →
Effect of drainage on postoperative pain after laparoscopic ovarian cystectomy
2015 ISSN: 0144-3615 SCI-Expanded
Prof. Dr. ÇETİN ÇELİK →
Anti Müllerian hormone is associated with extrauterine involvement and stage of disease in patients with endometrial cancer
2015 ISSN: 0144-3615 SCI-Expanded
Prof. Dr. ÇETİN ÇELİK →
Expression of cyclin A cyclin E and p27 in normal hyperplastic and frankly malignant endometrial samples
2013 ISSN: 0144-3615 SCI-Expanded
Prof. Dr. ÇETİN ÇELİK →
Assessment of body composition with bioelectrical impedance analysis in pregnant women with hyperemesis gravidarum before and after treatment
2015 ISSN: 0144-3615 SCI-Expanded
Prof. Dr. ÇETİN ÇELİK →
Management of intra-abdominally translocated contraceptive devices, is surgery the only way to treat this problem?
2017 ISSN: 0144-3615 SCI-Expanded
Prof. Dr. ÇETİN ÇELİK →
Makale Bilgileri
ISSN01443615
Yayın TarihiOcak 2017
Cilt / Sayfa37 · 58-63
Scopus ID2-s2.0-85007251024
Özet
We evaluated the concentrations of human epididymis secretory protein E4 (HE4) and Ca-125 in relation to clinicopathologic features in patients with endometrial cancer and premalignant endometrial lesions. Women with abnormal uterine bleeding (n = 167) who underwent endometrial sampling were divided into four groups. Group 1: endometrial cancer (n = 68), group 2: atypical endometrial hyperplasia (n = 12), group 3: endometrial hyperplasia without atypia (n = 39) and group 4: controls (n = 48). Women with endometrial cancer exhibited higher concentrations of HE4 levels than controls (91.4 pmol/L vs. 46.2 pmol/L, p < 0.001). HE4 levels were significantly higher in patients with lymphatic involvement, deep myometrial invasion, lymphovascular space involvement and non-endometrioid histology (p < 0.001). The sensitivity, specificity, positive and negative predictive values for HE4 in detecting endometrial cancer were 72.7%, 84.4%, 80% and 78.4%, respectively. Preoperative HE4 levels are more elevated in women with endometrial cancer than those with benign endometrium as well as in women with prognostic high-risk factors with endometrial cancer. HE4 may be used as an additional marker in combination with other clinicopathologic features for planning the treatment.
Yazarlar (10)
1
Setenay Arzu Yilmaz
2
Sündüz Özlem Altınkaya
3
Özlem Seçilmiş Kerimoğlu
ORCID: 0000-0003-2208-8712
4
Aybike Pekin
5
Fikret Akyürek
6
Tolgay Tuyan İlhan
7
Nilgün Benzer
8
Ali Ünlü
ORCID: 0000-0002-9991-3939
9
Hasan Yuksel
10
Çetin Çelik
ORCID: 0000-0001-6165-5092
Anahtar Kelimeler
atypical endometrial hyperplasia
Endometrial cancer
endometrial hyperplasia
endometrial hyperplasia without atypia
human epididymis secretory protein E4
Kurumlar
Aydin Adnan Menderes University
Aydin Turkey
Selçuk Tip Fakültesi
Konya Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Journal of Obstetrics and Gynaecology
Q3
OA
SJR Skoru0,459
H-Index61
YayıncıInforma Healthcare
ÜlkeUnited Kingdom
Obstetrics and Gynecology (Q3)
Metrikler
10
Atıf
10
Yazar
5
Anahtar Kelime