Scopus
YÖKSİS Eşleşti
Effect of calcium and vitamin D supplementation on the clinical, hormonal, and metabolic profile in non-obese women with polycystic ovary syndrome
Irish Journal of Medical Science · Aralık 2022
YÖKSİS Kayıtları
Effect of calcium and vitamin D supplementation on the clinical, hormonal, and metabolic profile in non-obese women with polycystic ovary syndrome
Effect of calcium and vitamin D supplementation on the clinical, hormonal, and metabolic profile in non-obese women with polycystic ovary syndrome · 2022 SCI-Expanded
PROFESÖR SETENAY ARZU YILMAZ →
Effect of calcium and vitamin D supplementation on the clinical, hormonal, and metabolic profile in non-obese women with polycystic ovary syndrome
Effect of calcium and vitamin D supplementation on the clinical, hormonal, and metabolic profile in non-obese women with polycystic ovary syndrome · 2022 SCI-Expanded
PROFESÖR ÇETİN ÇELİK →
Effect of calcium and vitamin D supplementation on the clinical, hormonal, and metabolic profile in non-obese women with polycystic ovary syndrome
Irish Journal of Medical Science (1971 -) · 2022 SCI-Expanded
ARAŞTIRMA GÖREVLİSİ ZEKİYE SOYKAN SERT →
Effect of calcium and vitamin D supplementation on the clinical, hormonal, and metabolic profile in non-obese women with polycystic ovary syndrome
Effect of calcium and vitamin D supplementation on the clinical, hormonal, and metabolic profile in non-obese women with polycystic ovary syndrome · 2022 SCI-Expanded
PROFESÖR ALİ ÜNLÜ →
Effect of calcium and vitamin D supplementation on the clinical, hormonal, and metabolic profile in non-obese women with polycystic ovary syndrome
IRISH JOURNAL OF MEDICAL SCIENCE · 2022 SCI
PROFESÖR ALİ ÜNLÜ →
Effect of calcium and vitamin D supplementation on the clinical, hormonal, and metabolic profile in non-obese women with polycystic ovary syndrome
IRISH JOURNAL OF MEDICAL SCIENCE · 2022 SCI-Expanded
PROFESÖR ALİ ÜNLÜ →
Effect of calcium and vitamin D supplementation on the clinical, hormonal, and metabolic profile in non-obese women with polycystic ovary syndrome
Irish Journal of Medical Science (1971 -) · 2022 SCI-Expanded
PROFESÖR ALİ ÜNLÜ →
Makale Bilgileri
DergiIrish Journal of Medical Science
Yayın TarihiAralık 2022
Cilt / Sayfa191 · 2657-2662
Scopus ID2-s2.0-85123925267
Özet
Background: In this study, we investigated the effect of calcium and vitamin D (Ca/Vit D) supplementation on the clinical, hormonal, and metabolic profile of patients with low vitamin D levels. In addition, we investigated the effect of Ca/Vit D supplementation on asymmetric dimethylarginine (ADMA) level in patients with polycystic ovary syndrome (PCOS). Methods: In total, 75 patients aged 19–35 years, with a normal body mass index and a diagnosis of PCOS and Vit D deficiency/insufficiency, were included in the study. Patients received 50,000 IU of vitamin D3 once a week for 8 weeks. Afterward, 2500 mg calcium carbonate equivalent to 1000 mg calcium ion and 9.68 mg cholecalciferol equivalent to 880 IU vitamin D3 were administered orally as a maintenance treatment once a day. Results: The mean age of the patients was 21.7 ± 3.5. After Ca/Vit D supplementation, Vit D levels significantly increased compared to baseline (8.6 ng/ml) levels. An increase in SHBG levels (p < 0.001), a decrease in total testosterone, FAI (p = 0.042), and ADMA levels (p < 0.001) were observed in the first and third months compared to the onset. Significant improvement compared to baseline was observed in menstrual irregularity and median mFG score. Conclusion: Ca/Vit D supplementation can improve PCOS symptoms such as menstrual dysfunction, hirsutism, and hyperandrogenism. It may be effective in reducing the risk of cardiovascular disease in patients with PCOS later in life by decreasing ADMA levels, which is an indicator of endothelial dysfunction.
Yazarlar (6)
1
Zekiye Soykan Sert
ORCID: 0000-0003-1496-3732
2
Setenay Arzu Yilmaz
3
Özlem Seçilmiş Kerimoğlu
ORCID: 0000-0003-2208-8712
4
Sedat Abusoglu
ORCID: 0000-0002-2984-0527
5
Ali Ünlü
ORCID: 0000-0002-9991-3939
6
Çetin Çelik
ORCID: 0000-0001-6165-5092
Anahtar Kelimeler
Asymmetric dimethylarginine
Calcium
Polycystic ovary syndrome
Vitamin D supplementation
Kurumlar
Aksaray Üniversitesi
Aksaray Turkey
Selçuk Tip Fakültesi
Konya Turkey
Metrikler
2
Atıf
6
Yazar
4
Anahtar Kelime