Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Comparison of the efficacy of prednisolone, montelukast, and omalizumab in an experimental allergic rhinitis model
Turkish Journal of Medical Sciences · Ocak 2014
YÖKSİS Kayıtları
Comparison of the efficacy of prednisolone montelukast and omalizumab in an experimental allergic rhinitis model
TURKISH JOURNAL OF MEDICAL SCIENCES · 2014 SCI-Expanded
PROFESÖR METE KAAN BOZKURT →
Makale Bilgileri
DergiTurkish Journal of Medical Sciences
Yayın TarihiOcak 2014
Cilt / Sayfa44 · 439-447
Scopus ID2-s2.0-84897900834
Erişim🔓 Açık Erişim
Özet
Aim: To compare the efficacy of prednisolone, montelukast, and omalizumab in reducing allergic symptoms and inflammation at tissue level in an experimental allergic rhinitis model. Materials and methods: Forty Sprague Dawley rats were randomized into 5 groups as naive (NS/NC), sensitized/challenged (S/C) by subcutaneous ovalbumin antigen injection, and montelukast-, prednisolone-, and omalizumab-treated groups. A nasal allergen challenge was performed every day from day 20 to day 26. The number of sneezes and nasal/eye rubbing movements, IL-4 and CysLT levels in serum, nasal and bronchoalveolar lavage fluids determined by ELISA, and histopathological findings of nasal mucosa, sinus, and lung tissues were compared. Results: All of the treatments significantly controlled the allergic symptoms of sneezing and nasal/eye rubbing (P < 0.05). IL-4 and CysLT levels on days 20 and 26 were significantly higher in the S/C group compared to the NS/NC group (P < 0.05). Montelukast significantly decreased serum and nasal IL-4 and CysLT levels (P < 0.05), prednisolone decreased nasal lavage IL-4 and CysLT levels (P < 0.05), and omalizumab lowered nasal lavage CysLT levels (P < 0.05). Conclusion: Prednisolone, montelukast, and omalizumab were found to be effective in controlling the allergic symptoms of allergic rhinitis and upper/lower airway inflammation in an experimental allergic rhinitis model. © TÜBİTAK.
Yazarlar (6)
1
Mete Kaan Bozkurt
ORCID: 0000-0002-3153-3294
2
Baykal Tulek
3
Banu Bozkurt
ORCID: 0000-0002-9847-3521
4
Nalan Akyürek
5
Mehmet Öz
6
Aysel Kiyici
Anahtar Kelimeler
Airway inflammation
Cysteinyl leukotriene
Experimental allergic rhinitis
Immunoglobulin E
Interleukin-4
Montelukast
Omalizumab
Prednisolone
Kurumlar
Gazi Üniversitesi
Ankara Turkey
Mevlana Üniversitesi
Konya Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
11
Atıf
6
Yazar
8
Anahtar Kelime