Scopus
YÖKSİS Eşleşti
Evaluation of the clinical efficacy of racecadotril in the treatment of neonatal calves with infectious diarrhea
Polish Journal of Veterinary Sciences · Ocak 2023
YÖKSİS Kayıtları
Evaluation of the clinical efficacy of racecadotril in the treatment of neonatal calves with infectious diarrhea
Polish journal of veterinary sciences · 2023 SCI-Expanded
DOÇENT MERVE İDER →
Evaluation of the clinical efficacy of racecadotril in the treatment of neonatal calves with infectious diarrhea
Polish journal of veterinary sciences · 2023 SCI-Expanded
PROFESÖR KAMİL ÜNEY →
Evaluation of the clinical efficacy of racecadotril in the treatment of neonatal calves with infectious diarrhea
Polish Academy of Sciences Chancellery · 2023 SCI-Expanded
PROFESÖR MAHMUT OK →
Evaluation of the clinical efficacy of racecadotril in the treatment of neonatal calves with infectious diarrhea
Polish journal of veterinary sciences · 2023 SCI-Expanded
PROFESÖR BÜNYAMİN TRAŞ →
Evaluation of the clinical efficacy of racecadotril in the treatment of neonatal calves with infectious diarrhea
Polish Journal of Veterinary Science · 2023 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ TUĞBA MELİKE PARLAK →
Evaluation of the clinical efficacy of racecadotril in the treatment of neonatal calves with infectious diarrhea
Polish journal of veterinary sciences · 2023 SCI-Expanded
PROFESÖR MAHMUT OK →
Makale Bilgileri
DergiPolish Journal of Veterinary Sciences
Yayın TarihiOcak 2023
Cilt / Sayfa26 · 559-569
Scopus ID2-s2.0-85179645315
Özet
Racecadotril, used as an antidiarrheal drug in humans and some animals such as the dog, inhibits peripheral enkephalinase, which degrades enkephalins and enkephalinase inhibition induces a selective increase in chloride absorption from the intestines. The study material consisted of 46 calves with infectious diarrhea and 14 healthy calves in the age 2-20 days. The calves were divided into eight groups; healthy calves (HG), healthy calves administered racecadotril (HRG), calves with E.coli-associated diarrhea (ECG), calves with E.coli-associated diarrhea administered racecadotril (ECRG), calves with bovine Rotavirus/Coronavirus-associated diarrhea (VG), calves with bovine Rotavirus/Coronavirus-associated diarrhea administered racecadotril (VRG), calves with C. parvum-associated diarrhea (CG) and calves with C. parvum-associated diarrhea administered racecadotril (CRG). Calves in the racecadotril groups received oral racecadotril at a dose of 2.5 mg/kg twice a day for 3 days. A routine clinical examination of all calves was performed. Hemogram and blood gas measurements were made from the blood samples. Standard diarrhea treatment was applied to the HG, ECG, CG, and VG groups. Clinical score parameters such as appetite, feces quality, dehydration, standing and death and some blood gas and hemogram parameters were evaluated to determine the clinical efficacy of racecadotril. Clinical score parameters were determined observationally. Blood gas measurements were performed using a blood gas analyzer. The hemogram was performed using an automated hematologic analyzer. Statistically significant differences were determined in the blood pH, bicarbonate, base deficit, lactate, and total leukocyte count in calves with diarrhea compared to healthy calves. After the treatments, these parameters were found to be within normal limits. At the end of treatment, 42 of the 46 diarrheal calves recovered, while 4 died. We found that racecadotril was effective in improving both clinical recovery and feces consistency in neonatal calves with diarrhea caused by E. coli. As a result, it can be stated that racecadotril, which has an antisecretory effect, is beneficial in the treatment of bacterial diarrhea caused by such as E. coli.
Yazarlar (8)
1
B. Traş
2
M. Ok
3
Merve Ider
ORCID: 0000-0003-2928-5452
4
T. M. Parlak
5
Ramazan Yildiz
6
Hatice Eser Faki
7
Zeynep Ozdemir Kutahya
8
Kamil Üney
ORCID: 0000-0002-8674-4873
Anahtar Kelimeler
infectious diarrhea
neonatal calf
racecadotril
treatment
Kurumlar
Burdur Mehmet Akif Ersoy Üniversitesi
Burdur Turkey
Çukurova Üniversitesi
Adana Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
1
Atıf
8
Yazar
4
Anahtar Kelime