Scopus
YÖKSİS Eşleşti
Evaluation of burn wound healing activity of thermosensitive gel and PLGA nanoparticle formulation of quercetin in Wistar albino rats
Journal of Drug Delivery Science and Technology · Eylül 2022
YÖKSİS Kayıtları
Evaluation of burn wound healing activity of thermosensitive gel and PLGA
nanoparticle formulation of quercetin in Wistar albino rats
Journal of Drug Delivery Science and Technology · 2022 SCI-Expanded
ARAŞTIRMA GÖREVLİSİ TAMER TEKİN →
Evaluation of burn wound healing activity of thermosensitive gel and PLGA
nanoparticle formulation of quercetin in Wistar albino rats
Journal of Drug Delivery Science and Technology · 2022 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ CENGİZHAN CEYLAN →
Evaluation of burn wound healing activity of thermosensitive gel and PLGA
nanoparticle formulation of quercetin in Wistar albino rats
Journal of Drug Delivery Science and Technology · 2022 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ YAKUP GÜLTEKİN →
Evaluation of burn wound healing activity of thermosensitive gel and PLGA
nanoparticle formulation of quercetin in Wistar albino rats
Journal of Drug Delivery Science and Technology · 2022 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ ŞEYMA TETİK RAMA →
Evaluation of burn wound healing activity of thermosensitive gel and PLGA nanoparticle formulation of quercetin in Wistar albino rats
Journal of Drug Delivery Science and Technology · 2022 SCI-Expanded
PROFESÖR ESMA MENEVŞE →
Evaluation of burn wound healing activity of thermosensitive gel and PLGA nanoparticle formulation of quercetin in Wistar albino rats
Journal of Drug Delivery Science and Technology · 2022 SCI-Expanded
PROFESÖR NİHAL ÇETİN →
Makale Bilgileri
DergiJournal of Drug Delivery Science and Technology
Yayın TarihiEylül 2022
Cilt / Sayfa75
Scopus ID2-s2.0-85135784541
Özet
Modern burn treatments with gene therapy, stem cells and healing factors are highly cost and not always possible to access these treatments. For this reason, new effective treatment approaches should have easy accessibility. Recent studies have shown that quercetin, a flavonoid, has a wound-healing effect. However, quercetin has low water solubility and cannot uptake into cells sufficiently. To overcome these disadvantages quercetin nanoparticle and thermosensitive gel formulations appear to be potential alternatives. In this study, to compare the efficacy of quercetin-loaded PLGA nanoparticle with quercetin-loaded pluronic thermosensitive gel formulations, nanoparticle and thermosensitive gel formulations were developed, characterized and evaluated in the burn model. Biochemical analysis has been performed to investigate the effects of formulations on such as growth factors and some cytokines that are effective in wound healing process. Finally, histopathological analyzes has been performed to evaluate the presence and density of granulation tissue, inflammation and fibrosis. Encapsulation efficiency (EE) of nanoparticles was found 25 ± 5%. It is indicating that during the preparation of PLGA nanoparticles, there is more quercetin lost than preparation process of gel. Also quercetin release from PLGA nanoparticles is limited when compared with gel formulation of quercetin. PLGA nanoparticles and thermosensitive gel formulations are effective when compared with quercetin solution and Silverdin®. Considering the cost of PLGA polymer, EE and efficacy results it was concluded that pluronic thermosensitive gel formulations could be a cost-effective option for burn wound therapy.
Yazarlar (8)
1
Nihal Cetin
2
Esma Menevşe
3
Zeliha Esin Celik
4
Cengizhan Ceylan
ORCID: 0000-0003-4164-9212
5
Seyma Tetik Rama
6
Yakup Gultekin
7
Tamer Tekin
8
Adem Sahin
ORCID: 0000-0002-3996-2931
Anahtar Kelimeler
Burn wound therapy
Nanoparticle
PLGA
Plunoric
Quercetin
Thermosensitive gel
Kurumlar
Bilecik Şeyh Edebali Üniversitesi
Bilecik Turkey
Selçuk Tip Fakültesi
Konya Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
7
Atıf
8
Yazar
6
Anahtar Kelime