Scopus
YÖKSİS DOI Eşleşti
SJR Q2
Echinophora tournefortii Jaub. & Spach: Evaluation of the effect on indomethacin-induced gastric ulser in rats and phytochemical analyses by LC-HRMS
Fitoterapia · Eylül 2024
YÖKSİS Kayıtları
Echinophora tournefortii Jaub. & Spach: Evaluation of the effect on indomethacin-induced gastric ulser in rats and phytochemical analyses by LC-HRMS
Fitoterapia · 2024 SCI-Expanded
Prof. Dr. ESMA MENEVŞE →
Echinophora tournefortii Jaub. & Spach: Evaluation of the effect on indomethacin-induced gastric ulser in rats and phytochemical analyses by LC-HRMS
Fitoterapia · 2024 SCI-Expanded
Dr. Öğr. Üyesi ŞEYMA TETİK RAMA →
Echinophora tournefortii Jaub. & Spach: Evaluation of the effect on indomethacin-induced gastric ulser in rats and phytochemical analyses by LC-HRMS
Fitoterapia · 2024 SCI-Expanded
Prof. Dr. OSMAN TUGAY →
Echinophora tournefortii Jaub. & Spach: Evaluation of the effect on
indomethacin-induced gastric ulser in rats and phytochemical analyses by
LC-HRMS
Fitoterapia · 2024 SCI-Expanded
Prof. Dr. ZELİHA ESİN ÇELİK →
Echinophora tournefortii Jaub. & Spach: Evaluation of the effect on indomethacin-induced gastric ulser in rats and phytochemical analyses by LC-HRMS
Fitoterapia · 2024 SCI-Expanded
Arş. Gör. TUĞSEN BÜYÜKYILDIRIM →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Prenylated polyphenolic compounds from Glycyrrhiza iconica and their antimicrobial and antioxidant activities
2015 ISSN: 0367326X SCI
Prof. Dr. YAVUZ BAĞCI →
Echinophora tournefortii Jaub. & Spach: Evaluation of the effect on indomethacin-induced gastric ulser in rats and phytochemical analyses by LC-HRMS
2024 ISSN: 0367-326X SCI-Expanded Q2
Dr. Öğr. Üyesi ŞEYMA TETİK RAMA →
Echinophora tournefortii Jaub. & Spach: Evaluation of the effect on indomethacin-induced gastric ulser in rats and phytochemical analyses by LC-HRMS
2024 ISSN: 0367-326X SCI-Expanded Q2
Prof. Dr. DENİZ ULUKUŞ →
Echinophora tournefortii Jaub. & Spach: Evaluation of the effect on indomethacin-induced gastric ulser in rats and phytochemical analyses by LC-HRMS
2024 ISSN: 0367-326X SCI-Expanded Q2
Prof. Dr. ESMA MENEVŞE →
Characterization of the chemical profiles and biological activities of Thesium bertramii Azn. Extracts using a combination of in vitro, in silico, and network pharmacology methods
2025 ISSN: 0367-326X SCI-Expanded Q2
Prof. Dr. EVREN YILDIZTUGAY →
Echinophora tournefortii Jaub. & Spach: Evaluation of the effect on indomethacin-induced gastric ulser in rats and phytochemical analyses by LC-HRMS
2024 ISSN: 0367-326X SCI-Expanded
Dr. Öğr. Üyesi NERİMAN AKDAM →
Echinophora tournefortii Jaub. & Spach: Evaluation of the effect on
indomethacin-induced gastric ulser in rats and phytochemical analyses by
LC-HRMS
2024 ISSN: 0367-326X SCI-Expanded
Prof. Dr. ZELİHA ESİN ÇELİK →
Echinophora tournefortii Jaub. & Spach: Evaluation of the effect on indomethacin-induced gastric ulser in rats and phytochemical analyses by LC-HRMS
2024 ISSN: 0367-326X SCI-Expanded Q3
Prof. Dr. OSMAN TUGAY →
Makale Bilgileri
Dergi
Fitoterapia
ISSN0367326X
Yayın TarihiEylül 2024
Cilt / Sayfa177
Scopus ID2-s2.0-85196557078
Özet
E. tournefortii has wound healing properties in folk medicine and 5% infusions are used for stomach ulcers. It is also used in colds, abdominal pain, digestive problems, as an appetite enhancer and antispasmodic. For this purpose, in the study biochemical and histopathological evaluation of the ulcer protective effect of the extract obtained from the E. tournefortii in the indomethacin-induced gastric ulcer model in rats was aimed to develop new strategies in the treatment of ulcers. The phytochemical profile of the plant was elucidated for the first time by LC-HRMS in this study. The results indicate that, in terms of TNF-α, IL-1β, IL-8, IL-6, PGE2, NF-κB, VEGF, NO, COX-1 and COX-2 biochemical parameters, E. tournefortii protects the gastric mucosa to the inflammation, and also modulates the PGE2 pathway, and has a similar effect or even a more positive effect than the reference substance lansoprazole. According to LC-HRMS analysis results, chlorogenic acid, genistein and quinic acid were the main constituents of E. tournefortii extract with 1397.081, 1014.177 and 992.527 μg/g extract, respectively. Considering the anti-inflammatory and antioxidant effects of these phenolic components, it is thought that the major components are responsible for the anti-ulcer activity of the E. tournefortii extract.
Yazarlar (11)
1
Cengizhan Ceylan
ORCID: 0000-0003-4164-9212
2
Nihal Cetin
3
Esma Menevşe
4
Zeliha Esin Celik
5
Neriman Akdam
6
Leyla Paşayeva
ORCID: 0000-0003-3860-7222
7
Osman Tugay
8
Seyma Tetik Rama
9
Tugsen Buyukyildirim
10
Hamiyet Kose
11
Deni̇Z Ulukuş
Anahtar Kelimeler
E. tournefortii
Gastric ulcer
LC-HRMS
PGE2
Protective effect
Kurumlar
Ankara Üniversitesi
Ankara Turkey
Erciyes Üniversitesi
Kayseri Turkey
Gazi Üniversitesi
Ankara Turkey
Selçuk Tip Fakültesi
Konya Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Fitoterapia
Q2
SJR Skoru0,537
H-Index130
YayıncıElsevier B.V.
ÜlkeNetherlands
Medicine (miscellaneous) (Q2)
Drug Discovery (Q3)
Pharmacology (Q3)
Metrikler
8
Atıf
11
Yazar
5
Anahtar Kelime