Scopus
YÖKSİS Eşleşti
Echinophora tournefortii Jaub. & Spach: Evaluation of the effect on indomethacin-induced gastric ulser in rats and phytochemical analyses by LC-HRMS
Fitoterapia · Eylül 2024
YÖKSİS Kayıtları
Echinophora tournefortii Jaub. & Spach: Evaluation of the effect on indomethacin-induced gastric ulser in rats and phytochemical analyses by LC-HRMS
Fitoterapia · 2024 SCI-Expanded
ARAŞTIRMA GÖREVLİSİ TUĞSEN BÜYÜKYILDIRIM →
Echinophora tournefortii Jaub. & Spach: Evaluation of the effect on indomethacin-induced gastric ulser in rats and phytochemical analyses by LC-HRMS
Fitoterapia · 2024 SCI-Expanded
PROFESÖR ESMA MENEVŞE →
Echinophora tournefortii Jaub. & Spach: Evaluation of the effect on indomethacin-induced gastric ulser in rats and phytochemical analyses by LC-HRMS
Fitoterapia · 2024 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ ŞEYMA TETİK RAMA →
Echinophora tournefortii Jaub. & Spach: Evaluation of the effect on indomethacin-induced gastric ulser in rats and phytochemical analyses by LC-HRMS
Fitoterapia · 2024 SCI-Expanded
PROFESÖR OSMAN TUGAY →
Echinophora tournefortii Jaub. & Spach: Evaluation of the effect on
indomethacin-induced gastric ulser in rats and phytochemical analyses by
LC-HRMS
Fitoterapia · 2024 SCI-Expanded
PROFESÖR ZELİHA ESİN ÇELİK →
Makale Bilgileri
DergiFitoterapia
Yayın TarihiEylül 2024
Cilt / Sayfa177
Scopus ID2-s2.0-85196557078
Özet
E. tournefortii has wound healing properties in folk medicine and 5% infusions are used for stomach ulcers. It is also used in colds, abdominal pain, digestive problems, as an appetite enhancer and antispasmodic. For this purpose, in the study biochemical and histopathological evaluation of the ulcer protective effect of the extract obtained from the E. tournefortii in the indomethacin-induced gastric ulcer model in rats was aimed to develop new strategies in the treatment of ulcers. The phytochemical profile of the plant was elucidated for the first time by LC-HRMS in this study. The results indicate that, in terms of TNF-α, IL-1β, IL-8, IL-6, PGE2, NF-κB, VEGF, NO, COX-1 and COX-2 biochemical parameters, E. tournefortii protects the gastric mucosa to the inflammation, and also modulates the PGE2 pathway, and has a similar effect or even a more positive effect than the reference substance lansoprazole. According to LC-HRMS analysis results, chlorogenic acid, genistein and quinic acid were the main constituents of E. tournefortii extract with 1397.081, 1014.177 and 992.527 μg/g extract, respectively. Considering the anti-inflammatory and antioxidant effects of these phenolic components, it is thought that the major components are responsible for the anti-ulcer activity of the E. tournefortii extract.
Yazarlar (11)
1
Cengizhan Ceylan
ORCID: 0000-0003-4164-9212
2
Nihal Cetin
3
Esma Menevşe
4
Zeliha Esin Celik
5
Neriman Akdam
6
Leyla Paşayeva
ORCID: 0000-0003-3860-7222
7
Osman Tugay
8
Seyma Tetik Rama
9
Tugsen Buyukyildirim
10
Hamiyet Kose
11
Deni̇Z Ulukuş
Anahtar Kelimeler
E. tournefortii
Gastric ulcer
LC-HRMS
PGE2
Protective effect
Kurumlar
Ankara Üniversitesi
Ankara Turkey
Erciyes Üniversitesi
Kayseri Turkey
Gazi Üniversitesi
Ankara Turkey
Selçuk Tip Fakültesi
Konya Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
1
Atıf
11
Yazar
5
Anahtar Kelime