Scopus
YÖKSİS DOI Eşleşti
SJR Q2
Investigation of Developmental Toxicity and Teratogenicity of Antiemetics on Rat Embryos Cultured In Vitro
Journal of Veterinary Medicine Series C Anatomia Histologia Embryologia · Ağustos 2013
YÖKSİS Kayıtları
Investigation of Developmental Toxicity and Teratogenicity of Antiemetics on Rat Embryos Cultured title
Anatomia, Histologia, Embryologia · 2013 SSCI
Prof. Dr. HASAN ACAR →
title Investigation of Developmental Toxicity and Teratogenicity of Antiemetics on Rat Embryos Cultured i In Vitro i title
Anatomia, Histologia, Embryologia · 2013 SSCI
Prof. Dr. HASAN ACAR →
Investigation of Developmental Toxicity and Teratogenicity of Antiemetics on Rat Embryos Cultured In Vitro
Anatomia, Histologia, Embryologia · 2013 SCI-Expanded
Prof. Dr. ZELİHA FAZLIOĞULLARI →
Investigation of Developmental Toxicity and Teratogenicity of Antiemetics on Rat Embryos Cultured In Vitro
Anatomia, Histologia, Embryologia · 2013 SCI-Expanded
Prof. Dr. ZELİHA FAZLIOĞULLARI →
YÖKSİS Kayıtları — ISSN Eşleşmesi
The Influence of Stomach Volume on the Liver Topography in Cats
2002 ISSN: 0340-2096 SCI 1 atıf
Prof. Dr. EMRULLAH EKEN →
Morphological Studies on Meckel s Diverticulum in Geese Anser Anser Domesticus
2002 ISSN: 0340-2096 SCI 4 atıf
Prof. Dr. EMRULLAH EKEN →
The Distribution of the Cardiac Veins in Angora Rabbits Oryctolagus cuniculus
2007 ISSN: 0340-2096 SCI 8 atıf
Prof. Dr. SADULLAH BAHAR →
The Distribution of the Coronary Arteries in the Angora Rabbit
2007 ISSN: 0340-2096 SSCI
Prof. Dr. SADULLAH BAHAR →
The Distribution of the Coronary Arteries in the Angora Rabbit
2007 ISSN: 0340-2096 SSCI
Prof. Dr. SADULLAH BAHAR →
Comparison of the Morphometric Features of the Left and Right Horse Kidneys A Stereological Approach
2013 ISSN: 03402096 SSCI
Prof. Dr. SADULLAH BAHAR →
The distribution of the coronary arteries in the angora rabbit
2007 ISSN: 0340-2096 SCI-Expanded 1 atıf
Prof. Dr. SADULLAH BAHAR →
Investigation of Developmental Toxicity and Teratogenicity of Macrolide Antibiotics in Cultured Rat Embryos
2008 ISSN: 03402096 SCI-Expanded
Prof. Dr. ZELİHA FAZLIOĞULLARI →
Investigation of Developmental Toxicity and Teratogenicity of Antiemetics on Rat Embryos Cultured In Vitro
2013 ISSN: 03402096 SCI-Expanded
Prof. Dr. ZELİHA FAZLIOĞULLARI →
Human Fetal Sacral Length Measurement for the Assessment of Fetal Growth and Development by Ultrasonography and Dissection
2001 ISSN: 0340-2096 SCI-Expanded
Prof. Dr. AHMET KAĞAN KARABULUT →
Comparison of the Morphometric Features of the Left and Right Horse Kidneys: A Stereological Approach
2013 ISSN: 03402096 SCI-Expanded Q3
Prof. Dr. SADULLAH BAHAR →
Morphological Studies on Meckel’s Diverticulum in Geese (Anser Anser Domesticus)
2002 ISSN: 0340-2096 SCI
Prof. Dr. KAMİL BEŞOLUK →
Comparative Macroanatomic Investigations of the Venous Drainage of the Heart in Akkaraman Sheep and Angora Goats
2001 ISSN: 0340-2096 SCI
Prof. Dr. KAMİL BEŞOLUK →
A three-dimensional reconstructive study of pelvic cavity in the red fox (Vulpes vulpes)
2021 ISSN: 0340-2096 SCI-Expanded Q3
Prof. Dr. EMRULLAH EKEN →
The Distribution of the Cardiac Veins in Angora Rabbits (Oryctolagus cuniculus)
2007 ISSN: 0340-2096 SCI-Expanded Q3
Prof. Dr. SADULLAH BAHAR →
The distribution of the coronary arteries in the angora rabbit
2007 ISSN: 0340-2096 SCI-Expanded
Prof. Dr. SADULLAH BAHAR →
Comparison of the Morphometric Features of the Left and Right HorseKidneys A Stereological Approach
2013 ISSN: 0340-2096 SCI-Expanded
Prof. Dr. SADULLAH BAHAR →
Morphometric analysis of the skull of Hamdani sheep via
Three‐Dimensional
modelling
2022 ISSN: 0340-2096 SCI-Expanded Q2
Prof. Dr. MUSTAFA ORHUN DAYAN →
Investigation of Developmental Toxicity and Teratogenicity of Antiemetics on Rat Embryos Cultured title
2013 ISSN: 03402096 SSCI
Prof. Dr. HASAN ACAR →
Calculation of cerebral hemispheres volume values (grey matter, white matter and lateral ventricle) of sheep and goat: A stereological study
2024 ISSN: 0340-2096 SCI-Expanded Q3
Dr. Öğr. Üyesi SEDAT AYDOĞDU →
Makale Bilgileri
ISSN03402096
Yayın TarihiAğustos 2013
Cilt / Sayfa42 · 239-246
Scopus ID2-s2.0-84880139791
Özet
In this study, we aimed to investigate and compare the direct toxic and teratogenic effects of dimenhydrinate, metoclopramide and trimethobenzamide HCl, antiemetic drugs on embryonic growth and development in cultured rat embryos. Embryos were explanted on day 9.5 of gestation and cultured. Whole rat serum was used as a culture medium for the control group while different concentrations of dimenhydrinate (2.5-20 μg/ml), metoclopramide (10-50 μg/ml) and trimethobenzamide HCl (25-100 μg/ml) were added to serum for the experimental groups. Effects of antiemetics on embryonic developmental parameters were compared, and embryos were evaluated for the presence of any malformations. Also, the total DNA was extracted from the cells to determine the fragmentation of nuclear DNA of embryonic cells. Compared with the control embryos, the antiemetics significantly decreased all growth and developmental parameters dose dependently. There was no difference regarding the fragmentation of nuclear DNA of the all used agents and controls. Amongst the agents, trimethobenzamide HCl was found to have more toxic and teratogenic potential, and metoclopramide appears to be the least toxic antiemetic and therefore could be more safely used and might be preferred for the treatment of nausea and vomiting in pregnancy. © 2012 Blackwell Verlag GmbH.
Yazarlar (5)
1
Zeliha Fazliogullari
ORCID: 0000-0002-5103-090X
2
Ahmet Kagan Karabulut
3
Ismihan Ilknur Uysal
4
Nadire Unver Dogan
5
Hasan Acar
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Journal of Veterinary Medicine Series C: Anatomia Histologia Embryologia
Q2
SJR Skoru0,317
H-Index46
YayıncıWiley-Blackwell Publishing Ltd
ÜlkeUnited Kingdom
Veterinary (miscellaneous) (Q2)
Medicine (miscellaneous) (Q3)
Metrikler
4
Atıf
5
Yazar