Scopus
YÖKSİS DOI Eşleşti
SJR Q3
Effects of enrofloxacin, flunixin meglumine and dexamethasone on disseminated intravascular coagulation, cytokine levels and adenosine deaminase activity in endotoxaemia in rats +
Acta Veterinaria Hungarica · Eylül 2010
YÖKSİS Kayıtları
EFFECTS OF ENROFLOXACIN FLUNIXIN MEGLUMINE AND DEXAMETHASONE ONDISSEMINATED INTRAVASCULAR COAGULATION CYTOKINE LEVELS AND ADENOSINEDEAMINASE ACTIVITY IN ENDOTOXAEMIA IN RATS
ACTA VETERINARIA HUNGARICA · 2010 SCI-Expanded 23 atıf
Prof. Dr. MUAMMER ELMAS →
Effects of enrofloxacin flunixin meglumine and dexamethasone on disseminated intravascular coagulation cytokine levels and adenosine deaminase activity in endotoxaemia in rats sup sup
Acta Veterinaria Hungarica · 2010 SCI-Expanded 8 atıf
Prof. Dr. KAMİL ÜNEY →
Effects of enrofloxacin flunixin meglumine and dexamethasone on disseminated intravascular coagulation cytokine levels and adenosine deaminase activity in endotoxaemia in rats sup sup
Acta Veterinaria Hungarica · 2010 SCI
Prof. Dr. AYŞE ER →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Zinc supplementation decreases total thyroid hormone concentration in small ruminants
2002 ISSN: 0236-6290 SCI 18 atıf
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Effects of bovine viral diarrhoea virus on the fertility of cows
2013 ISSN: 0236-6290 SSCI
Prof. Dr. SİBEL YAVRU →
ASSESSMENT OF THE CARDIOTOXICITY OF TULATHROMYCIN IN RABBITS
2011 ISSN: 0236-6290 SCI-Expanded 37 atıf
Prof. Dr. MUAMMER ELMAS →
EFFECTS OF ENROFLOXACIN FLUNIXIN MEGLUMINE AND DEXAMETHASONE ONDISSEMINATED INTRAVASCULAR COAGULATION CYTOKINE LEVELS AND ADENOSINEDEAMINASE ACTIVITY IN ENDOTOXAEMIA IN RATS
2010 ISSN: 0236-6290 SCI-Expanded 23 atıf
Prof. Dr. MUAMMER ELMAS →
EFFECTS OF TYLOSIN ON SERUM CYTOKINE LEVELS IN HEALTHY ANDLIPOPOLYSACCHARIDE TREATED MICE
2010 ISSN: 0236-6290 SCI-Expanded 18 atıf
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Zinc Supplementation Decreases Total Thyroid Hormone Concentration in Small Ruminants
2002 ISSN: 0236-6290 SCI-Expanded
Prof. Dr. ERCAN KESKİN →
Cardiac biomarkers in premature calves with respiratory distress syndrome
2016 ISSN: 0236-6290 SCI
Prof. Dr. HASAN GÜZELBEKTEŞ →
Effects of bovine viral diarrhoea virus on the fertility of cows
2013 ISSN: 0236-6290 SCI-Expanded
Prof. Dr. ORHAN YAPICI →
Effect of pentoxifylline on endotoxin induced haemostatic disturbances in rabbits
2005 ISSN: 0236-6290 SCI 7 atıf
Prof. Dr. RAMAZAN ÇÖL →
Effect of recombinant interleukin 10 on some haematological and biochemical parameters in a rat endotoxaemic model
2011 ISSN: 0236-6290 SCI 6 atıf
Prof. Dr. RAMAZAN ÇÖL →
Effects of Arginine and Trehalose on Post-thawed Bovine Sperm Quality
2017 ISSN: 0236-6290 SCI
Prof. Dr. MUSTAFA NUMAN BUCAK →
Effects of arginine and trehalose on post-thawed bovine sperm quality
2017 ISSN: 0236-6290 SCI
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Plasma disposition of cefoperazone after single intravenous and intramuscular administrations in camels (Camelus dromedarius) )/title
2018 ISSN: 0236-6290 SCI-Expanded
Prof. Dr. MUAMMER ELMAS →
title Plasma disposition of cefoperazone after single intravenous and intramuscular administrations in camels ( iCamelus dromedarius/i )/title
2018 ISSN: 0236-6290 SCI-Expanded
Prof. Dr. KAMİL ÜNEY →
Assessment of the cardiotoxicity of tulathromycin in rabbits
2011 ISSN: 0236-6290 SSCI
Prof. Dr. ENVER YAZAR →
Effect of pentoxifylline on endotoxin-induced haemostatic, disturbances in rabbits
2005 ISSN: 0236-6290 SCI-Expanded
Prof. Dr. ERCAN KESKİN →
Changes In Novel Gastrointestinal And Renal Injury Markers In The Blood Plasma Of Sheep Following Increasing Intravenous Doses Of Tolfenamic Acid
2019 ISSN: 0236-6290 SCI
Prof. Dr. MAHMUT OK →
Heart-type fatty acid-binding protein (H-FABP), pentraxin-3 (PTX-3) and thrombomodulin in bovine traumatic pericarditis
2019 ISSN: 0236-6290 SCI-Expanded Q3
Doç. Dr. MERVE İDER →
CHANGES IN NOVEL GASTROINTESTINAL AND RENAL INJURY MARKERS IN THE BLOOD PLASMA OF SHEEP FOLLOWING INCREASING INTRAVENOUS DOSES OF TOLFENAMIC ACID
2019 ISSN: 0236-6290 SCI
Prof. Dr. KAMİL ÜNEY →
Effects of tylosin, tilmicosin and tulathromycin on inflammatory mediators in bronchoalveolar lavage fluid of lipopolysaccharide-induced lung injury
2012 ISSN: 0236-6290 SCI-Expanded
Prof. Dr. ENVER YAZAR →
Makale Bilgileri
ISSN02366290
Yayın TarihiEylül 2010
Cilt / Sayfa58 · 357-367
Scopus ID2-s2.0-77955705446
Özet
The aim of this study was to determine the effects of drugs used in the treatment of endotoxaemia on disseminated intravascular coagulation, cytokine levels and adenosine deaminase activities in endotoxaemic rats. Rats were divided into seven groups. Lipopolysaccharide (LPS) was injected into all groups, including the positive control group. The other six groups received the following drugs: enrofloxacin (ENR), flunixin meglumine (FM), low-dose dexamethasone (DEX), high-dose DEX, ENR + FM + low-dose DEX, and ENR + FM + high-dose DEX. After the treatments, serum and plasma samples were collected at 0, 1, 2, 4, 6, 8, 12, 24 and 48 hours (h). A coagulometer was used to determine the levels of coagulation values, while ELISA was used to assay serum cytokines and adenosine deaminase (ADA). Low-dose DEX alone and combined treatments depressed the levels of cytokines and ADA (from 371 to 70 IU/L at 6 h) significantly and inhibited the decrease of coagulation values (antithrombin from 67 to 140% at 6 h, fibrinogen from 54 to 252 mg/dL at 6 h). In summary, FM + high-dose DEX may be the preferred treatment of endotoxaemia because of its highest effectiveness. FM plus high-dose DEX may be a new therapy for endotoxaemic domestic animals.
Yazarlar (7)
1
E. Yazar
2
A. Bulbul
3
G. E. Avci
4
A. Er
5
Kamil Üney
ORCID: 0000-0002-8674-4873
6
M. Elmas
7
B. Traş
Anahtar Kelimeler
cytokines
dexamethasone
disseminated intravascular coagulation
Endotoxaemia
enrofloxacin
flunixin
Kurumlar
Afyon Kocatepe Üniversitesi
Afyonkarahisar Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Acta Veterinaria Hungarica
Q3
SJR Skoru0,281
H-Index42
YayıncıAkademiai Kiado ZRt.
ÜlkeHungary
Veterinary (miscellaneous) (Q3)
Metrikler
14
Atıf
7
Yazar
6
Anahtar Kelime