Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
SJR Q3
Classification of high-grade endometrium carcinomas using molecular and immunohistochemical methods
Ginekologia Polska · Ocak 2023
YÖKSİS Kayıtları
Classification of high-grade endometrium carcinomas using molecular and immunohistochemical methods
Ginekologia Polska · 2023 SCI-Expanded
Prof. Dr. ÇETİN ÇELİK →
Classification of high-grade endometrium carcinomas using
molecular and immunohistochemical methods
Ginekologia Polska · 2023 SCI-Expanded
Prof. Dr. ÇETİN ÇELİK →
Classification of high-grade endometrium carcinomas using molecular and immunohistochemical methods
Ginekologia Polska · 2023 SCI-Expanded
Doç. Dr. ERSİN ÇİNTESUN →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Assessment of clinicopathological features evaluation of treatment and prognosis of clear cell and serous papillary endometrial carcinoma
2016 ISSN: 0017-0011 SCI-Expanded
Prof. Dr. MEHMET KULHAN →
Retrospective evaluation of clinical and pathological features as well as diagnostic and treatment protocols of primary vaginal malignancy
2016 ISSN: 0017-0011 SCI-Expanded
Prof. Dr. MEHMET KULHAN →
Urodynamic assessment of short term effects of pelvic radiotherapy on bladder function in patients with gynecologic cancers
2016 ISSN: 0017-0011 SCI-Expanded
Prof. Dr. MEHMET KULHAN →
Can neutrophil-lymphocyte and platelet-lymphocyte ratios predict threatened abortion and early pregnancy loss?
2020 ISSN: 0017-0011 SCI-Expanded
Prof. Dr. MEHMET KULHAN →
The struggle against endometrial cancer: ten years of
experience of a tertiary center
2022 ISSN: 0017-0011 SCI-Expanded Q4
Prof. Dr. ÇETİN ÇELİK →
The struggle against endometrial cancer: ten years of experience of a tertiary center
2022 ISSN: 0017-0011 SCI-Expanded Q4
Doç. Dr. AHMET BİLGİ →
Classification of high-grade endometrium carcinomas using molecular and immunohistochemical methods
2023 ISSN: 0017-0011 SCI-Expanded Q3
Doç. Dr. ERSİN ÇİNTESUN →
Classification of high-grade endometrium carcinomas using
molecular and immunohistochemical methods
2023 ISSN: 0017-0011 SCI-Expanded Q4
Prof. Dr. ÇETİN ÇELİK →
Endocervical polyps in high risk human papillomavirus infections
2022 ISSN: 0017-0011 SCI-Expanded Q4
Prof. Dr. FATİH KARA →
Classification of high-grade endometrium carcinomas using molecular and immunohistochemical methods
2023 ISSN: 0017-0011 SCI-Expanded Q4
Prof. Dr. ÇETİN ÇELİK →
Makale Bilgileri
Dergi
Ginekologia Polska
ISSN00170011
Yayın TarihiOcak 2023
Cilt / Sayfa94 · 3-11
Scopus ID2-s2.0-85135618970
Erişim🔓 Açık Erişim
Özet
Objectives: As a result of the integration of molecular changes into the histological classification of cancers, which increases diagnostic repeatability, the differences between the groups become more prominent and targeted therapies gain significance. The most comprehensive molecular study regarding endometrial carcinomas (EC) is The Cancer Genome Atlas (TCGA) project. According to TCGA, endometrial carcinomas are classified into four molecular prognostic subgroups: copy-number-low/p53-wild-type (p53wt), DNA polymerase epsilon (POLE)-mutated/ultramutated (POLEmt), microsatellite-instability/hypermutated (MSI), and copy-number-high/p53-mutated (p53mt). In this study, we aim to apply the molecular classification to our high-grade endometrial cancer patients, and particularly, to identify our overtreated patients. Material and methods: Ninety-seven patients diagnosed with high-grade EC in Selcuk University, Faculty of Medicine between 2009-2018 were retrospectively evaluated and classified into four subgroups. Primary outcomes of overall and progression-free survival were evaluated for clinical, pathological, and molecular features. Further, all molecular groups were divided into endometroid and non-endometrioid groups, and disease-free survival (DFS) and overall survival (OS) were investigated across groups. Results: According to molecular classification, 23 patients (23.7%) were assigned to the MSI group, 21 (21.6%) to the POLEmt group, 40 (41.2%) to the p53mt group, and 13 (13.4%) to the p53wt group. Patients’ DFS (p = 0.001) and OS rates (p = 0.001) were significantly different according to their molecular classification. The results of our analyses determined that, in the molecular classification of high-grade ECs, the p53mt group had the poorest prognosis and the POLEmt group had the best prognosis. Tumor size, myometrial invasion, lymphovascular space invasion (LVSI), lymph node metastasis, cervical invasion, ovarian invasion and stage showed statistically significant differences based on molecular classification (p < 0.05). Conclusions: The use of molecular classification in the clinical practice will allow more accurate prognostic prediction and more appropriate treatment planning, particularly as high-grade ECs constitute a heterogenous group with poor prognosis.
Yazarlar (7)
1
Denizhan Bayramoglu
2
Özlem Seçilmiş Kerimoğlu
ORCID: 0000-0003-2208-8712
3
Zeynep Bayramoğlu
ORCID: 0000-0001-7075-8819
4
Ersin Çintesun
ORCID: 0000-0001-8507-5850
5
Gözde Şahin
ORCID: 0000-0003-3067-9125
6
Pınar Karabağlı
ORCID: 0000-0002-5558-0175
7
Çetin Çelik
ORCID: 0000-0001-6165-5092
Anahtar Kelimeler
endometrial cancer
high-grade
MMR gene
molecular classification
p53
POLE
prognosis
Kurumlar
Konya Education and Research Hospital
Konya Turkey
Selçuk Tip Fakültesi
Konya Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Ginekologia Polska
Q3
OA
SJR Skoru0,399
H-Index33
YayıncıVia Medica
ÜlkePoland
Obstetrics and Gynecology (Q3)
Metrikler
5
Atıf
7
Yazar
7
Anahtar Kelime