Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Enzyme Inhibitory Properties, Antioxidant Activities, and Phytochemical Profile of Three Medicinal Plants from Turkey
Advances in Pharmacological Sciences · Ocak 2015
YÖKSİS Kayıtları
Enzyme Inhibitory Properties Antioxidant Activities and Phytochemical Profile of Three Medicinal Plants from Turkey
Advances in Pharmacological Sciences · 2015 SCI-Expanded
PROFESÖR ABDURRAHMAN AKTÜMSEK →
Makale Bilgileri
DergiAdvances in Pharmacological Sciences
Yayın TarihiOcak 2015
Cilt / Sayfa2015
Scopus ID2-s2.0-84954483473
Erişim🔓 Açık Erişim
Özet
We aimed to investigate the inhibitory potential of three medicinal plants (Hedysarum varium, Onobrychis hypargyrea, and Vicia truncatula) from Turkey against key enzymes involved in human pathologies, namely, diabetes (α-amylase and α-glucosidase), neurodegenerative disorders (tyrosinase, acetylcholinesterase, and butyrylcholinesterase), and hyperpigmentation (tyrosinase). The antioxidant potential, phenolic and flavonoid content of ethyl acetate, and methanolic and aqueous extracts were investigated using in vitro assays. The total antioxidant capacity (TAC), β-carotene/linoleic acid bleaching activity, 1,1-diphenyl-2-picrylhydrazyl free radical (DPPH•), 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS•+), cupric ion reducing antioxidant capacity (CUPRAC), ferric reducing antioxidant power (FRAP), and metal chelating activity on ferrous ions were used to evaluate the antioxidant capabilities of the extracts. The half-maximal inhibitory concentrations (IC50) of the extracts on cholinesterase, tyrosinase, and α-amylase were significantly higher than the references, galantamine, kojic acid, and acarbose, respectively. The half-maximal effective concentrations (EC50) of the extracts on TAC, CUPRAC, and FRAP were significantly higher than trolox. The phenol and flavonoid contents of the plant extracts were in the range 20.90 ± 0.190 - 83.25 ± 0.914 mg gallic acid equivalent/g extract and 1.45 ± 0.200 - 39.71 ± 0.092 mg rutin equivalent/g extract, respectively. The plants were found to possess moderate antioxidant capacities and interesting inhibitory action against key enzymes.
Yazarlar (6)
1
Gokhan Zengin
ORCID: 0000-0001-6548-7823
2
Gokalp Ozmen Guler
3
Abdurrahman Aktumsek
4
Ramazan Ceylan
5
Carene Marie Nancy Picot-Allain
6
Mohamad Fawzi Mahomoodally
Kurumlar
Necmettin Erbakan Üniversitesi
Meram Turkey
Selçuk Üniversitesi
Selçuklu Turkey
University of Mauritius
Reduit Mauritius
Metrikler
45
Atıf
6
Yazar