Scopus
🔓 Açık Erişim
Total phenolics, flavonoids, condensed tannins content of eight centaurea species and their broad inhibitory activities against cholinesterase, tyrosinase, α-amylase and α-glucosidase
Notulae Botanicae Horti Agrobotanici Cluj-Napoca · Ocak 2016
Makale Bilgileri
DergiNotulae Botanicae Horti Agrobotanici Cluj-Napoca
Yayın TarihiOcak 2016
Cilt / Sayfa44 · 195-200
Scopus ID2-s2.0-84975893920
Erişim🔓 Açık Erişim
Özet
Several bioactive compounds originate from natural sources and their uses are generally related with traditional or folk medicine. Synthetic drugs can have adverse side effects and, for this reason, the investigation of novel, safe, and naturaloccurring products can account for the development of new drugs. The genus Centaurea L. is one of the most important genera of the Asteraceae family, containing more than 200 species in the Turkish flora, about 140 of which are endemic. The aim of the present work was to determine enzyme inhibitory potentials of two extracts (chloroform and ethyl acetate) from eight Centaurea species against cholinesterase, tyrosinase, amylase, and glucosidase. The total phenolics, flavonoids and condensed tannin contents were also reported for each extract. These components in the extracts varied according to species and extraction solvents as well as enzyme inhibitory effects. The highest level of phenolics was found to be in the chloroform extract of C. pulchella (119.23 mg GAEs/g extract). Generally, chloroform extracts exhibited stronger enzyme inhibitory effects as compared to ethyl acetate. Additionally, possible correlations with total phenolics, flavonoids, and condensed tannins content were also highlighted. This paper is the first report of the inhibitory capacities of the eight Centaurea species on the selected enzymes. The present results may be a valuable starting point in the development of new bioactive formulations.
Yazarlar (5)
1
Gokhan Zengin
ORCID: 0000-0001-6548-7823
2
Marcello Locatelli
ORCID: 0000-0002-0840-825X
3
Simone Carradori
4
Andrei Mocan
5
Abdurrahman Aktumsek
Anahtar Kelimeler
Bioactive compounds
Enzyme inhibition
Natural products
Turkey
Kurumlar
Interuniversity Consortium of Structural and Systems Biology
Rome Italy
Selçuk Üniversitesi
Selçuklu Turkey
Universitatea de Medicina si Farmacie Iuliu Hatieganu din Cluj-Napoca
Cluj Napoca Romania
University of G. d'Annunzio Chieti and Pescara
Chieti Italy
Metrikler
47
Atıf
5
Yazar
4
Anahtar Kelime