Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Evaluation of antioxidant, enzyme inhibition, and cytotoxic activity of three anthraquinones (alizarin, purpurin, and quinizarin)
Human and Experimental Toxicology · Mayıs 2016
YÖKSİS Kayıtları
Evaluation of antioxidant enzyme inhibition and cytotoxic activity of three anthraquinones alizarin purpurin and quinizarin
Human & Experimental Toxicology · 2016 SCI
PROFESÖR ABDURRAHMAN AKTÜMSEK →
Evaluation of antioxidant enzyme inhibition and cytotoxic activity of three anthraquinones alizarin purpurin and quinizarin
Human & Experimental Toxicology · 2015 SCI
PROFESÖR GÖKHAN ZENGİN →
Makale Bilgileri
DergiHuman and Experimental Toxicology
Yayın TarihiMayıs 2016
Cilt / Sayfa35 · 544-553
Scopus ID2-s2.0-84964782115
Erişim🔓 Açık Erişim
Özet
Objective: The aim of this work was to investigate the cytotoxic, antioxidative, and enzyme inhibition effects of alizarin, quinizarin, and purpurin, which are anthraquinones (AQ). Methods: Cytotoxic effects were evaluated with cell inhibition rate by 3-(4,5-dimethylthiazol- 2-yl)-2,5-diphenyltetrazolium bromide assay. Different chemical assays, including free radical scavenging activity (1,1-diphenyl-2-picrylhydrazyl and 2,2-azino-bis(3-ethylbenzothiazloine-6-sulfonic acid)), phosphomolybdenum and reducing power (ferric reducing antioxidant power and cupric ion reducing activity), were used to evaluate the antioxidant properties. Moreover, enzyme inhibitory activities were analyzed against acetylcholinesterase, butrylcholinesterase, tyrosinase, α-amylase, and α-glucosidase. Results: These components have antioxidant and enzyme inhibition activity. Especially, purpurin showed the strongest antioxidant and good enzyme inhibitory effects. According to our cytotoxicity results, alizarin, purpurin, and quinizarin induced dose- and time-dependent cell proliferation. Furthermore, when we applied AQs with mitomycin C (MC) on L929 cell line, we demonstrated that cell proliferation in MC-AQ groups compared with MC group was increased. The most effective component was alizarin at 100 μM concentration. These AQs showed positive effects on L929 cell lines with high half-maximal inhibitory concentration values. Conclusion: Our results demonstrate that AQs may be used as antioxidative compounds in food and medicinal applications.
Yazarlar (4)
1
Gokhan Zengin
ORCID: 0000-0001-6548-7823
2
Nurdan Sena Degirmenci
3
Lokman Alpsoy
4
Abdurrahman Aktumsek
Anahtar Kelimeler
Alizarin
cytotoxic effect
enzyme inhibition
purpurin
quinizarin
Kurumlar
Fatih Üniversitesi
Istanbul Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
56
Atıf
4
Yazar
5
Anahtar Kelime