Scopus
Enzyme inhibitory effect and antioxidant properties of astragalus lagurus extracts
Current Enzyme Inhibition · Ağustos 2016
Makale Bilgileri
DergiCurrent Enzyme Inhibition
Yayın TarihiAğustos 2016
Cilt / Sayfa12 · 177-182
Scopus ID2-s2.0-84981711230
Özet
Antioxidant and enzyme inhibitory effects (against cholinesterase, tyrosinase, α-amylase and α-glucosidase) of ethyl acetate, methanol, and aqueous extracts from Astragalus lagurus (Fabaceae) were investigated with spectrophotometric methods. Antioxidant capacity were evaluated by using different assay including free radical scavenging (DPPH and ABTS), reducing power (FRAP and CUPRAC), phosphomolybdenum, and metal chelating experiments. Total phenolic and flavonoid content was also determined as 20.34-20.72 mg GAEs/g and 19.58-31.10 mg REs/g, respectively. Generally, A. lagurus ethyl acetate and aqueous extracts were observed to possess higher antioxidant and enzyme inhibitory effects compared to methanol extract. The aqueous extract exhibited the strongest free radical scavenging activity on DPPH (20.65 mg TEs/g) and ABTS (67.43 mg TEs/g) as well as on reducing power tests (73.98 mg TEs/g for CUPRAC and 53.49 mg TEs/g for FRAP). ş-Amylase and α-glucosidase inhibition were found to be 0.12-0.56 and 1.45-1.82 mmol ACAEs/g. These findings suggest that A. lagurus could provide natural biologically active agents to be used in food and pharmaceutical industry.
Yazarlar (6)
1
Gokhan Zengin
ORCID: 0000-0001-6548-7823
2
Ramazan Ceylan
3
Gokalp Ozmen Guler
4
Simone Carradori
5
Sengul Uysal
6
Abdurrahman Aktumsek
Anahtar Kelimeler
Antioxidant
Astragalus
Enzyme inhibition
Phenolic
Turkey
Kurumlar
Necmettin Erbakan Üniversitesi
Meram Turkey
Selçuk Üniversitesi
Selçuklu Turkey
University of G. d'Annunzio Chieti and Pescara
Chieti Italy
Metrikler
20
Atıf
6
Yazar
5
Anahtar Kelime