Scopus
🔓 Açık Erişim
Enzymatic assays and molecular modeling studies of Schisandra chinensis lignans and phenolics from fruit and leaf extracts
Journal of Enzyme Inhibition and Medicinal Chemistry · Kasım 2016
Makale Bilgileri
DergiJournal of Enzyme Inhibition and Medicinal Chemistry
Yayın TarihiKasım 2016
Cilt / Sayfa31 · 200-210
Scopus ID2-s2.0-85006274955
Erişim🔓 Açık Erişim
Özet
Considerable interest has been shown in natural sources and their compounds in developing new therapeutically agents for different diseases. In this framework, investigations performed on this topic play a central role for human health and drug development process. Schisandra chinensis (Turcz.) Baill is a medicinal and edible plant showing highly advantageous bioactivity and nutritional value. The main bioactive compounds from its fruits are lignans, derivatives of dibenzocyclooctadiene whereas concerning its leaves, phenolic acids, and flavonoids are dominant. The purpose of this study was to investigate the enzyme inhibitory potential on selected carbohydrate hydrolases, cholinesterases, and tyrosinase of extracts from fruits and leaves of Schisandra in relation with their main bioactive compounds. Furthermore, the interactions between dominant compounds (schisandrol A, schisandrol B, schisandrin B, and cinnamic acid) from extracts and selected enzymes were investigated by molecular modeling and molecular dynamic studies in order to explain at a molecular level our findings.
Yazarlar (4)
1
Andrei Mocan
2
Gokhan Zengin
ORCID: 0000-0001-6548-7823
3
Gianina Crişan
4
Adriano Mollica
Anahtar Kelimeler
Enzyme inhibition
lignans
molecular modeling
phenolics
Schisandra chinensis
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Universitatea de Medicina si Farmacie Iuliu Hatieganu din Cluj-Napoca
Cluj Napoca Romania
University of G. d'Annunzio Chieti and Pescara
Chieti Italy
Metrikler
67
Atıf
4
Yazar
5
Anahtar Kelime