Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Functional constituents of wild and cultivated Goji (L. barbarum L.) leaves: phytochemical characterization, biological profile, and computational studies
Journal of Enzyme Inhibition and Medicinal Chemistry · Ocak 2017
YÖKSİS Kayıtları
Functional constituents of wild and cultivated Goji (L. barbarum L.) leaves: phytochemical characterization, biological profile, and computational studies
Journal of Enzyme Inhibition and Medicinal Chemistry · 2017 SCI-Expanded
PROFESÖR GÖKHAN ZENGİN →
Makale Bilgileri
DergiJournal of Enzyme Inhibition and Medicinal Chemistry
Yayın TarihiOcak 2017
Cilt / Sayfa32 · 153-168
Scopus ID2-s2.0-85015607567
Erişim🔓 Açık Erişim
Özet
Goji (Lycium barbarum L.) leaves are emphasized as a functional tea or as dietary supplements. The phenolic compound profile, antioxidant, enzyme inhibitory, antimicrobial, and antimutagenic activities of leaf extracts from two selected cultivars in comparison with wild-growing plants have been evaluated. HPLC-DAD/ESI-ToF-MS analysis revealed the presence of phenolic acids and flavonoids with chlorogenic acid and rutin being the dominant compounds in the cultivated plants, whereas rutin and kaempeferol-3-O-rutinoside for wild growing ones. In particular, cv. Erma contained the highest amount of chlorogenic acid and showed a strong tyrosinase-inhibitory effect. Staphylococcus aureus, Listeria monocytogenes, and Penicillium funiculosum were the most sensitive strains when exposed to extracts from cultivated plants. Antimutagenic activity was evaluated by Ames' test. The tested extracts provided high protection against mutagenicity induced by 2-anthramine (2-AA) to Salmonella typhimurium strains TA 98 and TA 100 (max. inhibition (%) 88% and 74.2%, respectively). Overall, Goji leaves are a rich source of bioactive compounds with functional properties that need further risk/benefit evaluation when used in foods or health-promoting formulations.
Yazarlar (8)
1
Andrei Mocan
2
Gokhan Zengin
ORCID: 0000-0001-6548-7823
3
Mario Simirgiotis
4
Michaela Schafberg
5
Adriano Mollica
6
Dan C. Vodnar
7
Gianina Crişan
8
Sascha Rohn
Anahtar Kelimeler
Antibacterial activity
antimutagenicity
enzyme inhibition
Goji leaves
phenolic compounds
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Universidad Austral de Chile
Valdivia Chile
Universitatea de Medicina si Farmacie Iuliu Hatieganu din Cluj-Napoca
Cluj Napoca Romania
Universitatea de Stiinte Agricole si Medicina Veterinara din Cluj-Napoca
Cluj Napoca Romania
Universität Hamburg
Hamburg Germany
University of G. d'Annunzio Chieti and Pescara
Chieti Italy
Metrikler
161
Atıf
8
Yazar
5
Anahtar Kelime