Scopus
🔓 Açık Erişim
Neem oil nanoemulsions: characterisation and antioxidant activity
Journal of Enzyme Inhibition and Medicinal Chemistry · Ocak 2017
Makale Bilgileri
DergiJournal of Enzyme Inhibition and Medicinal Chemistry
Yayın TarihiOcak 2017
Cilt / Sayfa32 · 1265-1273
Scopus ID2-s2.0-85030480751
Erişim🔓 Açık Erişim
Özet
The aim of the present work is to develop nanoemulsions (NEs), nanosized emulsions, manufactured for improving the delivery of active pharmaceutical ingredients. In particular, nanoemulsions composed of Neem seed oil, contain rich bioactive components, and Tween 20 as nonionic surfactant were prepared. A mean droplet size ranging from 10 to 100 nm was obtained by modulating the oil/surfactant ratio. Physicochemical characterisation was carried out evaluating size, ζ-potential, microviscosity, polarity and turbidity of the external shell and morphology, along with stability in simulated cerebrospinal fluid (CSF), activity of Neem oil alone and in NEs, HEp-2 cell interaction and cytotoxicity studies. This study confirms the formation of NEs by Tween 20 and Neem oil at different weight ratios with small and homogenous dimensions. The antioxidant activity of Neem oil alone and in NEs was comparable, whereas its cytotoxicity was strongly reduced when loaded in NEs after interaction with HEp-2 cells.
Yazarlar (11)
1
Federica Rinaldi
2
Patrizia Nadia Hanieh
3
Catia Longhi
4
Simone Carradori
5
Daniela Secci
6
Gokhan Zengin
ORCID: 0000-0001-6548-7823
7
Maria Grazia Ammendolia
8
Elena Mattia
9
Elena Del Favero
10
Carlotta Marianecci
11
Maria Carafa
Anahtar Kelimeler
antioxidant activity
cell interaction studies
nanoemulsions
Neem oil
physicochemical characterisation
Kurumlar
Facoltà di Farmacia e Medicina
Rome Italy
Istituto Italiano di Tecnologia
Genoa Italy
Istituto Superiore Di Sanita
Rome Italy
Sapienza Università di Roma
Rome Italy
Selçuk Üniversitesi
Selçuklu Turkey
Università degli Studi di Milano
Milan Italy
University of G. d'Annunzio Chieti and Pescara
Chieti Italy
Metrikler
53
Atıf
11
Yazar
5
Anahtar Kelime