Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Novel perspectives on two Digitalis species: Phenolic profile, bioactivity, enzyme inhibition, and toxicological evaluation
South African Journal of Botany · Mart 2017
YÖKSİS Kayıtları
Novel perspectives on two Digitalis species: Phenolic profile, bioactivity, enzyme inhibition, and toxicological evaluation
South African Journal of Botany · 2017 SCI-Expanded
PROFESÖR ABDURRAHMAN AKTÜMSEK →
Novel perspectives on two Digitalis species: Phenolic profile, bioactivity, enzyme inhibition, and toxicological evaluation
South African Journal of Botany · 2017 SCI-Expanded
PROFESÖR GÖKHAN ZENGİN →
Makale Bilgileri
DergiSouth African Journal of Botany
Yayın TarihiMart 2017
Cilt / Sayfa109 · 50-57
Scopus ID2-s2.0-85007608301
Erişim🔓 Açık Erişim
Özet
The present study outlines the phenolic composition of methanolic extracts of Digitalis ferruginea and Digitalis lamarckii aerial parts and evaluates their biological activities. The quantification of phenolic compounds was carried out by HPLC–DAD analysis. Antioxidant properties were assessed using different assays. Enzyme inhibition was tested on AChE, BChE, α-amylase, α-glucosidase, and tyrosinase. The antimicrobial properties of the extracts were determined using the microdilution method. Genotoxicity of the extracts was assessed on Drosophila melanogaster by comet assay. D. lamarcki extract was richer in phenolic compounds than D. ferruginea, with chlorogenic acid as dominant compound in both D. lamarckii and D. ferruginea extracts (2.99 and 1.30 mg/g, respectively). Both extracts showed similar values in terms of antioxidant activity. The extracts showed enzyme inhibitory activity on above-mentioned enzymes and moderate antimicrobial activity (MIC range 0.625–10 mg/mL). D. ferruginea extract (20 mg/mL) indicated the absence of genotoxicity, while all concentrations of D. lamarckii extract showed significant DNA damage. Antigenotoxic effect was more evident in the group treated with D. lamarckii extract, 80 mg/mL (%R = 80.3). The results emphasized the biological potential of examined plants and encourage further studies for their potential use as phytopharmaceuticals.
Yazarlar (8)
1
Jelena S. Katanić Stanković
2
Ramazan Ceylan
3
Sanja Matić
4
Tatjana Jurić
5
Gokhan Zengin
ORCID: 0000-0001-6548-7823
6
Abdurrahman Aktumsek
7
Vladimir Mihailović
8
Snežana Stanić
Anahtar Kelimeler
Antigenotoxic
Antimicrobial
Antioxidant
Digitalis
HPLC
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
University of Kragujevac
Kragujevac Serbia
Metrikler
13
Atıf
8
Yazar
5
Anahtar Kelime