Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
Cytotoxic and enzyme inhibitory potential of two potentilla species (P. speciosa L. and P. reptans Willd.) and their chemical composition
Frontiers in Pharmacology · Mayıs 2017
YÖKSİS Kayıtları
Cytotoxic and Enzyme Inhibitory Potential of Two Potentilla species (P. speciosa L. and P. reptans Willd.) and Their Chemical Composition
Frontiers in Pharmacology · 2017 SCI-Expanded
Prof. Dr. GÖKHAN ZENGİN →
Cytotoxic and Enzyme Inhibitory Potential of Two Potentilla species (P-speciosa L. and P-reptans Willd.) and Their Chemical Composition
FRONTIERS IN PHARMACOLOGY · 2017 SCI
Prof. Dr. GÖKHAN ZENGİN →
Cytotoxic and Enzyme Inhibitory Potential of Two Potentilla species (P. speciosa L. and P. reptans Willd.) and Their Chemical Composition
Frontiers in Pharmacology · 2017 SCI-Expanded
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
Makale Bilgileri
Dergi
Frontiers in Pharmacology
Yayın TarihiMayıs 2017
Cilt / Sayfa8
Scopus ID2-s2.0-85019599140
Erişim🔓 Açık Erişim
Özet
In this work, the biological and chemical fingerprints of three extracts (ethyl acetate, methanol, and water) from two Potentilla species (Potentilla reptans and P. speciosa) were investigated. Antioxidant, enzyme inhibitory, and cytotoxic activities were performed for the biological fingerprint. For the chemical characterization, total bioactive components, and individual phenolic components were determined using photometric and HPLC methods, respectively. The main identified phenolic compounds in these extracts were rutin and catechin. Methanol and water extracts contained the highest total phenolic and flavonoid content. The results of antioxidant assays showed that methanol and water extracts displayed higher antioxidant activity compared to the ethyl acetate extract. Generally, methanol and water extracts exhibited higher biological activities correlated with higher levels the bioactive components. For P. speciosa, the methanol extract exhibited the highest enzyme inhibitory activity (except BChE inhibitory activity). P. reptans exhibited also high antiproliferative activity against MCF-7 cells whilst P. speciosa had weak to moderate activity against both of A549 and MCF-7 cell lines. The results suggest that Potentilla species could be potential candidates for developing new phyto-pharmaceuticals and functional ingredients.
Yazarlar (9)
1
Sengul Uysal
2
Gokhan Zengin
ORCID: 0000-0001-6548-7823
3
Marcello Locatelli
ORCID: 0000-0002-0840-825X
4
Mir Babak Bahadori
5
Andrei Mocan
6
Giuseppe Bellagamba
7
Elisa De Luca
8
Adriano Mollica
9
Abdurrahman Aktumsek
Anahtar Kelimeler
Antioxidant activity
Cytotoxic
Enzyme inhibitory activity
Potentilla reptans
P. speciosa
Kurumlar
Interuniversity Consortium of Structural and Systems Biology
Roma Italy
Research Center for Pharmaceutical Nanotechnology
Tabriz Iran
Selçuk Üniversitesi
Selçuklu Turkey
Universitatea de Medicina si Farmacie Iuliu Hatieganu din Cluj-Napoca
Cluj Napoca Romania
University of G. d'Annunzio Chieti and Pescara
Chieti Italy
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Metrikler
339
Atıf
9
Yazar
5
Anahtar Kelime