Scopus
YÖKSİS DOI Eşleşti
SJR Q2
In vitro and in silico insights of Cupressus sempervirens, Artemisia absinthium and Lippia triphylla: Bridging traditional knowledge and scientific validation
European Journal of Integrative Medicine · Haziran 2017
YÖKSİS Kayıtları
In vitro and in silico insights of Cupressus sempervirens , Artemisia absinthium and Lippia triphylla : Bridging traditional knowledge and scientific validation
European Journal of Integrative Medicine · 2017 SCI-Expanded
Prof. Dr. GÖKHAN ZENGİN →
In vitro and in silico insights of Cupressus sempervirens , Artemisia absinthium and Lippia triphylla : Bridging traditional knowledge and scientific validation
European Journal of Integrative Medicine · 2017 SCI-Expanded
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
YÖKSİS Kayıtları — ISSN Eşleşmesi
In vitro and in silico insights of Cupressus sempervirens , Artemisia absinthium and Lippia triphylla : Bridging traditional knowledge and scientific validation
2017 ISSN: 18763820 SCI-Expanded
Prof. Dr. GÖKHAN ZENGİN →
In vitro antioxidant, cytotoxicity and chemical profile of different extracts from Acanthus hirsutus Boiss used in Anatolian folk medicine
2018 ISSN: 1876-3820 SCI-Expanded
Prof. Dr. GÖKHAN ZENGİN →
In vitro antioxidant, cytotoxicity and chemical profile of different extracts from Acanthus hirsutus Boiss used in Anatolian folk medicine
2018 ISSN: 1876-3820 SCI
Prof. Dr. GÖKHAN ZENGİN →
Makale Bilgileri
ISSN18763820
Yayın TarihiHaziran 2017
Cilt / Sayfa12 · 135-141
Scopus ID2-s2.0-85020633358
Özet
Introduction The search for new therapeutic agents for the management of diabetes mellitus type 2 (DMT2) and neurodegenerative disorders coupled with the rising number of patients suffering from these pathologies have attracted much interest. Traditionally, extracts from medicinal plants have been used to manage a number of ailments and still remain a potent source of new therapeutic agents. Methods Therefore, the present study was undertaken to evaluate the in vitro antioxidant and enzyme (acetyl cholinesterase (AChE), butyryl cholinesterase (BChE), tyrosinase, α-amylase, and α-glucosidase) inhibitory potential of three medicinal plants (Cupressus sempervirens, Artemisia absinthium, and Lippia triphylla). The phenolic composition of the ethanolic extracts was also characterized using reversed-phase high-performance liquid chromatography (RP-HPLC). In silico molecular docking was used to investigate the possible interaction between active compounds and the studied enzymes. Results C. sempervirens showed the highest inhibition rates against AChE, BChE, α-amylase, and α-glucosidase (2.47 mg galantamine equivalents (GALAE)/g extract, 2.98 mg GALAE/g extract, 1.61 mmol acarbose equivalents (ACAE)/g extract, and 1.86 mmol ACAE/g extract for respective enzymes). The plant extracts showed antioxidant power in the following order C. sempervirens > L. triphylla > A. absinthium. Protocatechuic acid, (+)-catechin, apigenin, and chlorogenic acid were identified in all the plant extracts. The best docking pose obtained for each bioactive compound against the enzymes was mostly stabilized via hydrogen bonds and pi–pi stacks. Conclusion This study provides insight into the antioxidant capacity and the inhibitory potential of these medicinal plants against key enzymes linked to DMT2 and neurodegenerative disorders.
Yazarlar (5)
1
Gokhan Zengin
ORCID: 0000-0001-6548-7823
2
Adriano Mollica
3
Abdurrahman Aktumsek
4
Carene Marie Nancy Picot
5
Mohamad Fawzi Mahomoodally
Anahtar Kelimeler
Antioxidant
Bioactive compounds
Cupressus sempervirens
Diabetes
Lippia triphylla
Molecular docking
Neurodegenerative disorders
Traditional medicine
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
University of G. d'Annunzio Chieti and Pescara
Chieti Italy
University of Mauritius
Reduit Mauritius
Scimago Dergi (ISSN Eşleşmesi)
European Journal of Integrative Medicine
Q2
SJR Skoru0,399
H-Index42
YayıncıElsevier GmbH
ÜlkeGermany
Complementary and Alternative Medicine (Q2)
Metrikler
26
Atıf
5
Yazar
8
Anahtar Kelime