Scopus
YÖKSİS Eşleşti
Bioactivities of Achillea phrygia and Bupleurum croceum based on the composition of phenolic compounds: In vitro and in silico approaches
Food and Chemical Toxicology · Eylül 2017
YÖKSİS Kayıtları
Bioactivities of Achillea phrygia and Bupleurum croceum based on the composition of phenolic compounds: In vitro and in silico approaches
Food and Chemical Toxicology · 2017 SCI-Expanded
PROFESÖR GÖKHAN ZENGİN →
Bioactivities of Achillea phrygia and Bupleurum croceum based on the composition of phenolic compounds: In vitro and in silico approaches
Food and Chemical Toxicology · 2017 SCI
PROFESÖR GÖKHAN ZENGİN →
Bioactivities of Achillea phrygia and Bupleurum croceum based on the composition of phenolic compounds: In vitro and in silico approaches
Food and Chemical Toxicology · 2017 SCI-Expanded
PROFESÖR GÖKHAN ZENGİN →
Bioactivities of Achillea phrygia and Bupleurum croceum based on the composition of phenolic compounds: In vitro and in silico approaches
Food and Chemical Toxicology · 2017 SCI-Expanded
PROFESÖR ABDURRAHMAN AKTÜMSEK →
Makale Bilgileri
DergiFood and Chemical Toxicology
Yayın TarihiEylül 2017
Cilt / Sayfa107 · 597-608
Scopus ID2-s2.0-85016074762
Özet
This study presents the effects of the Achillea phrygia Boiss. et Bal. and Bupleurum croceum Fenzl. extracts obtained by different solvents (ethyl acetate, methanol and water) on selected enzyme inhibitory effects and antioxidant ability with screening bioactive compounds. Total and individual bioactive compounds were detected by spectrophotometric and HPLC-DAD techniques. Antioxidant abilities were evaluated by different methods including free radical scavenging (ABTS and DPPH), reducing power (CUPRAC and FRAP), phosphomolybdenum and metal chelating. Enzyme inhibitory effects were tested against cholinesterases, tyrosinase, amylase, glucosidase and lipase. Total phenolic contents were ranged from 20.52 mgGAE/g extract (B. croceum methanol extract) to 41.13 mgGAE/g extract (A. phrygia methanol extract). Generally, methanol and water extracts showed the strongest antioxidant abilities, while the ethyl acetate extracts had the most promising enzyme inhibitory effects. HPLC analysis revealed the abundance of some phenolics including rutin, quercetin, sinapic acid and chlorogenic acid, respectively. These components were also assessed using molecular modelling with the aim to study their docking properties on a set of six enzymes used in this study. Overall, these species could be suggested as valuable sources of natural-bioactive agents for developing new functional, pharmacological and health-promoting ingredients.
Yazarlar (6)
1
Gokhan Zengin
ORCID: 0000-0001-6548-7823
2
Gizem Bulut
3
Adriano Mollica
4
Mehmet Zeki Haznedaroglu
5
Ahmet Dogan
6
Abdurrahman Aktumsek
Anahtar Kelimeler
Achiella phrygia
Bioactive compounds
Bupleurum croceum
Natural agents
Turkey
Kurumlar
Ege Üniversitesi
Izmir Turkey
Marmara Üniversitesi
Istanbul Turkey
Selçuk Üniversitesi
Selçuklu Turkey
University of G. d'Annunzio Chieti and Pescara
Chieti Italy
Metrikler
27
Atıf
6
Yazar
5
Anahtar Kelime