Scopus
YÖKSİS Eşleşti
Combining in vitro, in vivo and in silico approaches to evaluate nutraceutical potentials and chemical fingerprints of Moltkia aurea and Moltkia coerulea
Food and Chemical Toxicology · Eylül 2017
YÖKSİS Kayıtları
Combining in vitro , in vivo and in silico approaches to evaluate nutraceutical potentials and chemical fingerprints of Moltkia aurea and Moltkia coerulea
Food and Chemical Toxicology · 2017 SCI
PROFESÖR GÖKHAN ZENGİN →
Combining in vitro , in vivo and in silico approaches to evaluate nutraceutical potentials and chemical fingerprints of Moltkia aurea and Moltkia coerulea
Food and Chemical Toxicology · 2017 SCI-Expanded
PROFESÖR GÖKHAN ZENGİN →
Combining in vitro , in vivo and in silico approaches to evaluate nutraceutical potentials and chemical fingerprints of Moltkia aurea and Moltkia coerulea
Food and Chemical Toxicology · 2017 SCI-Expanded
PROFESÖR ABDURRAHMAN AKTÜMSEK →
Makale Bilgileri
DergiFood and Chemical Toxicology
Yayın TarihiEylül 2017
Cilt / Sayfa107 · 540-553
Scopus ID2-s2.0-85017408622
Özet
Methanolic extracts of Moltkia aurea Boiss. (MA) and Moltkia coerulea (Willd.) Lehm. (MC) were investigated for their antioxidant capacity and enzymatic inhibitory potential against acetylcholinesterase, butyrylcholinesterase, α-amylase, α-glucosidase, and tyrosinase in vitro. MA and MC were also explored for their antimicrobial effect, as well as for their possible genotoxic/antigenotoxic potential on Drosophila melanogaster in vivo. The total bioactive components (phenolic (TPC) and flavonoid contents (TFC)) were determined and liquid chromatography-tandem mass spectrometry (LC-MS/MS) metabolite profiling of MA and MC appraised. The plausible docking poses of bioactive compounds to key enzymes were further studied using molecular modelling approach. MA proved to be a better antioxidant with higher TPC and TFC compared to MC. Protocatechuic acid, rutin, hesperidin and malic acid were the most abundant in these extracts. Both MA and MC exhibited antigenotoxic potential with a %R in DNA damage of 60.90 and 53.14% respectively. The docking studies revealed that rutin, hesperidin, and rosmarinic acid have the best scores for all the enzymes tested. MA and MC were found to be rich in phytochemicals with potent antioxidant, antimicrobial, and antigenotoxic activities that can be further studied for the management of neurodegenerative complications, diabetes, and hyperpigmentation.
Yazarlar (12)
1
Gokhan Zengin
ORCID: 0000-0001-6548-7823
2
Ramazan Ceylan
3
Jelena S. Katanić Stanković
4
Adriano Mollica
5
Abdurrahman Aktumsek
6
Tatjana Jurić
7
Sanja Matić
8
Vladimir Mihailović
9
Snežana Stanić
10
Zaahira Aumeeruddy-Elalfi
11
Mustafa Abdullah Yılmaz
12
Mohamad Fawzi Mahomoodally
Anahtar Kelimeler
Antigenotoxic
Antimicrobial
Antioxidant
Anti-tyrosinase
Molecular docking
Natural products
Kurumlar
Dicle Üniversitesi
Diyarbakir Turkey
Selçuk Üniversitesi
Selçuklu Turkey
University of G. d'Annunzio Chieti and Pescara
Chieti Italy
University of Kragujevac
Kragujevac Serbia
University of Mauritius
Reduit Mauritius
Metrikler
30
Atıf
12
Yazar
6
Anahtar Kelime