Scopus
🔓 Açık Erişim
Chemical composition of essential oil, antioxidant, antidiabetic, anti-obesity, and neuroprotective Properties of Prangos gaubae
Natural Product Communications · Aralık 2017
Makale Bilgileri
DergiNatural Product Communications
Yayın TarihiAralık 2017
Cilt / Sayfa12 · 1945-1948
Scopus ID2-s2.0-85039788568
Erişim🔓 Açık Erişim
Özet
Chemical composition of essential oil and the potential of Prangos gaubae for the management of public health problems such as Alzheimer's disease, obesity, Diabetes mellitus, and skin diseases were evaluated for the first time. In this direction, enzyme inhibitory effects, antioxidant activity, and total bioactive contents of the plant were determined. EO showed high acetylcholinesterase (2.97 mg GEs/g oil), α-Amylase (1.35 mmol ACEs/g oil), α-glucosidase (38.84 mmol ACEs/g oil), and lipase (1.59 mmol OEs/g oil) inhibitory activities. Moreover, strong antioxidant effects were observed in antiradical (DPPH and ABTS), reducing power (CUPRAC and FRAP), total antioxidant, and metal chelating assays. Methanol extract exhibited promising DPPH radical scavenging activity (0.47 mmol TEs/g extract) and also high reducing power in CUPRAC (0.89 mmol TEs/g extract) and FRAP (0.52 mmol TEs/g extract) assays. All extracts showed low total flavonoid but high total phenolics content. Furthermore, they exhibited strong skin-care effect in tyrosinase inhibition assay. EO analysis showed the presence of germacrene D (26.7%), caryophyllene oxide (14.3%), (E)-caryophyllene (13.8%), and spathulenol (11.3%) as the major volatile components. Results indicated that P. gaubae has promising potential for possible uses in food, cosmetic, and pharmaceutical industries due to its valuable phytoconstituents and biological activities.
Yazarlar (5)
1
Mir Babak Bahadori
2
Gokhan Zengin
ORCID: 0000-0001-6548-7823
3
Shahram Bahadori
4
Filippo Maggi
ORCID: 0000-0003-1375-4744
5
Leila Dinparast
Anahtar Kelimeler
Alzheimer's disease
Antioxidant
Diabetes mellitus
Essential oil.
Obesity
Prangos gaubae
Kurumlar
Biotechnology Research Center,Tabriz
Tabriz Iran
Islamic Azad University, Urmia Branch
Urmia Iran
Research Center for Pharmaceutical Nanotechnology
Tabriz Iran
Selçuk Üniversitesi
Selçuklu Turkey
Università degli Studi di Camerino
Camerino Italy
Metrikler
30
Atıf
5
Yazar
6
Anahtar Kelime