Scopus
YÖKSİS DOI Eşleşti
SJR Q1
Phenolic components and assessment of biological properties of Tchihatchewia isatidea Boiss. extracts: Docking and functional approaches for designing novel products
Food and Chemical Toxicology · Ocak 2018
YÖKSİS Kayıtları
Phenolic components and assessment of biological properties of Tchihatchewia isatidea Boiss. extracts: Docking and functional approaches for designing novel products
FOOD AND CHEMICAL TOXICOLOGY · 2018 SCI
Prof. Dr. GÖKHAN ZENGİN →
YÖKSİS Kayıtları — ISSN Eşleşmesi
In vitro antioxidant capacities and fatty acid compositions of three Centaurea species collected from Central Anatolia region of Turkey
2010 ISSN: 02786915 SCI 15 atıf
Prof. Dr. GÖKHAN ZENGİN →
Screening for in vitro antioxidant properties and fatty acid profiles of five Centaurea L species from Turkey flora
2011 ISSN: 02786915 SCI 12 atıf
Prof. Dr. GÖKHAN ZENGİN →
Antioxidant potentials and anticholinesterase activities of methanolic and aqueous extracts of three endemic Centaurea L species
2013 ISSN: 02786915 SCI-Expanded
Prof. Dr. GÖKHAN ZENGİN →
Antioxidant potentials and anticholinesterase activities of methanolic and aqueous extracts of three endemic Centaurea L species
2013 ISSN: 02786915 SCI-Expanded
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
Screening for in vitro antioxidant properties and fatty acid profiles of five Centaurea L species from Turkey flora
2011 ISSN: 02786915 SCI-Expanded
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
In vitro antioxidant capacities and fatty acid compositions of three Centaurea species collected from Central Anatolia region of Turkey
2010 ISSN: 02786915 SCI-Expanded
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
Organochlorine pesticide residues in wheat from Konya region Turkey
2010 ISSN: 02786915 SCI-Expanded
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
Mineral and heavy metal levels of some fruits grown at the roadsides
2010 ISSN: 0278-6915 SCI-Expanded
Öğr. Gör. NESİM DURSUN →
Mineral and heavy metal levels of some fruits grown at the roadsides
2010 ISSN: 0278-6915 SSCI 23 atıf
Prof. Dr. SAİT GEZGİN →
Phytochemical contents and enzyme inhibitory and antioxidant properties of Anethum graveolens L dill samples cultivated under organic and conventional agricultural conditions
2013 ISSN: 0278-6915 SCI-Expanded Q1
Dr. Öğr. Üyesi SADİYE AYŞE ÇELİK →
Biological effects and chemical characterization of Iris schachtii Markgr. extracts: A new source of bioactive constituents
2018 ISSN: 0278-6915 SCI
Dr. Öğr. Üyesi ERDOĞAN GÜNEŞ →
Novel in vitro and in silico insights of the multi-biological activities and chemical composition of Bidens tripartita L.
2018 ISSN: 02786915 SCI
Prof. Dr. GÖKHAN ZENGİN →
Bioactivities of Achillea phrygia and Bupleurum croceum based on the composition of phenolic compounds: In vitro and in silico approaches
2017 ISSN: 02786915 SCI
Prof. Dr. GÖKHAN ZENGİN →
Bioactivities of Achillea phrygia and Bupleurum croceum based on the composition of phenolic compounds: In vitro and in silico approaches
2017 ISSN: 02786915 SCI-Expanded
Prof. Dr. GÖKHAN ZENGİN →
Combining in vitro , in vivo and in silico approaches to evaluate nutraceutical potentials and chemical fingerprints of Moltkia aurea and Moltkia coerulea
2017 ISSN: 02786915 SCI-Expanded
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
Evaluation of antioxidant potential, enzyme inhibition activity and phenolic profile of Lathyrus cicera and Lathyrus digitatus : Potential sources of bioactive compounds for the food industry
2017 ISSN: 02786915 SCI-Expanded
Prof. Dr. GÖKHAN ZENGİN →
Combining in vitro , in vivo and in silico approaches to evaluate nutraceutical potentials and chemical fingerprints of Moltkia aurea and Moltkia coerulea
2017 ISSN: 02786915 SCI
Prof. Dr. GÖKHAN ZENGİN →
UHPLC-QTOF-MS analysis of bioactive constituents from two Romanian Goji (Lycium barbarum L.) berries cultivars and their antioxidant, enzyme inhibitory, and real-time cytotoxicological evaluation
2018 ISSN: 0278-6915 SCI
Prof. Dr. GÖKHAN ZENGİN →
Investigations into the therapeutic potential of Asphodeline liburnica roots: In vitro and in silico biochemical and toxicological perspectives
2018 ISSN: 0278-6915 SCI-Expanded
Prof. Dr. GÖKHAN ZENGİN →
Novel in vitro and in silico insights of the multi-biological activities and chemical composition of Bidens tripartita L.
2018 ISSN: 0278-6915 SCI-Expanded
Prof. Dr. GÖKHAN ZENGİN →
Makale Bilgileri
ISSN02786915
Yayın TarihiOcak 2018
Cilt / Sayfa111 · 423-431
Scopus ID2-s2.0-85036556616
Özet
The potentiality of bioactive phenolic compounds may result in plant extracts having multiple biological activities. The aim of this study was to investigate into the biological activities of the methanolic, ethyl acetate, and water extracts of Tchihatchewia isatidea Boiss, an endemic medicinal plant of Turkey. The phenolic compositions of the extracts were confirmed using RP-HPLC. Extracts were screened for their potential antioxidant through a panoply of assays; their anti-diabetic potential, and plausible inhibitory activity against tyrosinase and acetylcholinesterase. Molecular modelling methods were also used to assess the docking properties of phenolic compounds on tyrosinase. The major and most abundant compounds were rosmarinic acid (570 ± 14 μg/g extract in the methanolic extract), ferrulic acid (336 ± 6 μg/g extract in the methanolic extract), (+)-catechin (340 ± 4 μg/g extract in the water extract), apigenin (182 ± 4 μg/g extract in the methanolic extract), and epicatechin (188 ± 12 μg/g extract in the water extract). Radical scavenging, reducing capacity, and metal chelating activities were detected in the extracts, with preponderance activity observed in the methanolic extract. In conclusion, the potential clinical applications observed during this study may provide new insights into the molecular aspect particularly for neuroprotective and anti-diabetic mechanisms involving oxidative stress.
Yazarlar (6)
1
Gokhan Zengin
ORCID: 0000-0001-6548-7823
2
Hassan H. Abdallah
3
Ahmet Dogan
4
Adriano Mollica
5
Zaahira Aumeeruddy-Elalfi
6
Mohamad Fawzi Mahomoodally
Anahtar Kelimeler
Anti-diabetic
Antioxidant
Molecular docking
Phenolics
Tchihatchewia isatidea
Tyrosinase inhibitor
Kurumlar
Marmara Üniversitesi
Istanbul Turkey
Salahaddin University-Erbil
Erbil Iraq
Selçuk Üniversitesi
Selçuklu Turkey
Universiti Sains Malaysia
Minden Malaysia
University of G. d'Annunzio Chieti and Pescara
Chieti Italy
University of Mauritius
Reduit Mauritius
Scimago Dergi (ISSN Eşleşmesi)
Food and Chemical Toxicology
Q1
SJR Skoru0,750
H-Index223
YayıncıElsevier Ltd
ÜlkeUnited Kingdom
Food Science (Q1)
Medicine (miscellaneous) (Q2)
Toxicology (Q2)
Metrikler
10
Atıf
6
Yazar
6
Anahtar Kelime