Scopus
YÖKSİS DOI Eşleşti
SJR Q1
Novel in vitro and in silico insights of the multi-biological activities and chemical composition of Bidens tripartita L.
Food and Chemical Toxicology · Ocak 2018
YÖKSİS Kayıtları
Novel in vitro and in silico insights of the multi-biological activities and chemical composition of Bidens tripartita L.
Food and Chemical Toxicology · 2018 SCI
Prof. Dr. GÖKHAN ZENGİN →
Novel in vitro and in silico insights of the multi-biological activities and chemical composition of Bidens tripartita L.
FOOD AND CHEMICAL TOXICOLOGY · 2018 SCI
Prof. Dr. GÖKHAN ZENGİN →
YÖKSİS Kayıtları — ISSN Eşleşmesi
In vitro antioxidant capacities and fatty acid compositions of three Centaurea species collected from Central Anatolia region of Turkey
2010 ISSN: 02786915 SCI 15 atıf
Prof. Dr. GÖKHAN ZENGİN →
Screening for in vitro antioxidant properties and fatty acid profiles of five Centaurea L species from Turkey flora
2011 ISSN: 02786915 SCI 12 atıf
Prof. Dr. GÖKHAN ZENGİN →
Antioxidant potentials and anticholinesterase activities of methanolic and aqueous extracts of three endemic Centaurea L species
2013 ISSN: 02786915 SCI-Expanded
Prof. Dr. GÖKHAN ZENGİN →
Antioxidant potentials and anticholinesterase activities of methanolic and aqueous extracts of three endemic Centaurea L species
2013 ISSN: 02786915 SCI-Expanded
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
Screening for in vitro antioxidant properties and fatty acid profiles of five Centaurea L species from Turkey flora
2011 ISSN: 02786915 SCI-Expanded
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
In vitro antioxidant capacities and fatty acid compositions of three Centaurea species collected from Central Anatolia region of Turkey
2010 ISSN: 02786915 SCI-Expanded
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
Organochlorine pesticide residues in wheat from Konya region Turkey
2010 ISSN: 02786915 SCI-Expanded
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
Mineral and heavy metal levels of some fruits grown at the roadsides
2010 ISSN: 0278-6915 SCI-Expanded
Öğr. Gör. NESİM DURSUN →
Mineral and heavy metal levels of some fruits grown at the roadsides
2010 ISSN: 0278-6915 SSCI 23 atıf
Prof. Dr. SAİT GEZGİN →
Phytochemical contents and enzyme inhibitory and antioxidant properties of Anethum graveolens L dill samples cultivated under organic and conventional agricultural conditions
2013 ISSN: 0278-6915 SCI-Expanded Q1
Dr. Öğr. Üyesi SADİYE AYŞE ÇELİK →
Biological effects and chemical characterization of Iris schachtii Markgr. extracts: A new source of bioactive constituents
2018 ISSN: 0278-6915 SCI
Dr. Öğr. Üyesi ERDOĞAN GÜNEŞ →
Novel in vitro and in silico insights of the multi-biological activities and chemical composition of Bidens tripartita L.
2018 ISSN: 02786915 SCI
Prof. Dr. GÖKHAN ZENGİN →
Bioactivities of Achillea phrygia and Bupleurum croceum based on the composition of phenolic compounds: In vitro and in silico approaches
2017 ISSN: 02786915 SCI
Prof. Dr. GÖKHAN ZENGİN →
Bioactivities of Achillea phrygia and Bupleurum croceum based on the composition of phenolic compounds: In vitro and in silico approaches
2017 ISSN: 02786915 SCI-Expanded
Prof. Dr. GÖKHAN ZENGİN →
Combining in vitro , in vivo and in silico approaches to evaluate nutraceutical potentials and chemical fingerprints of Moltkia aurea and Moltkia coerulea
2017 ISSN: 02786915 SCI-Expanded
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
Evaluation of antioxidant potential, enzyme inhibition activity and phenolic profile of Lathyrus cicera and Lathyrus digitatus : Potential sources of bioactive compounds for the food industry
2017 ISSN: 02786915 SCI-Expanded
Prof. Dr. GÖKHAN ZENGİN →
Combining in vitro , in vivo and in silico approaches to evaluate nutraceutical potentials and chemical fingerprints of Moltkia aurea and Moltkia coerulea
2017 ISSN: 02786915 SCI
Prof. Dr. GÖKHAN ZENGİN →
UHPLC-QTOF-MS analysis of bioactive constituents from two Romanian Goji (Lycium barbarum L.) berries cultivars and their antioxidant, enzyme inhibitory, and real-time cytotoxicological evaluation
2018 ISSN: 0278-6915 SCI
Prof. Dr. GÖKHAN ZENGİN →
Investigations into the therapeutic potential of Asphodeline liburnica roots: In vitro and in silico biochemical and toxicological perspectives
2018 ISSN: 0278-6915 SCI-Expanded
Prof. Dr. GÖKHAN ZENGİN →
Novel in vitro and in silico insights of the multi-biological activities and chemical composition of Bidens tripartita L.
2018 ISSN: 0278-6915 SCI-Expanded
Prof. Dr. GÖKHAN ZENGİN →
Makale Bilgileri
ISSN02786915
Yayın TarihiOcak 2018
Cilt / Sayfa111 · 525-536
Scopus ID2-s2.0-85037711133
Özet
Bidens tripartita L. is a traditional phyto-remedy used in several countries, yet there is still a paucity of data on its biological potential. We aimed to provide new insights on the pharmacological potential of extracts prepared from B. tripartita via highlighting its antioxidant, key enzymes inhibitory potency, and DNA protecting effects. Phytochemical profile was established using High-Performance Liquid Chromatography with Diode-Array Detection (HPLC-DAD) and bioactive compound(s) docked against target enzymes using in silico methods. Cytotoxicity against three cancer cell lines was assessed using the methylthiazolyldiphenyl-tetrazolium bromide (MTT) cell viability test. The main compounds were luteolin-7-glucoside (cynaroside), chlorogenic acid, and epicatechin in the extracts. The methanol extract exhibited the highest radical scavenging activity. Ethyl acetate extract showed strongest α-amylase inhibitory activity, while the best α-glucosidase inhibitory effect recorded for the methanol extract. Molecular docking showed that cynaroside strongly interact to α-glucosidase cavity by establishing six hydrogen bonds. B. tripartita extracts were found to protect supercoiled form of pUC19 plasmid (>70%) and also showed anti-proliferative properties. Results amassed in the present study add on to a growing body of literature on the multi-pharmacological potency of B. tripartita which can be applied to bio-products development geared towards management of common diseases.
Yazarlar (10)
1
Sengul Uysal
2
Aslı Ugurlu Bayarslan
ORCID: 0000-0003-2131-2823
3
Gokhan Zengin
ORCID: 0000-0001-6548-7823
4
Mehmet Cengiz Baloglu
5
Yasemin Celik Altunoglu
6
Adriano Mollica
7
Luisa Custodio
8
Nuno R. Neng
9
José M.F. Nogueira
10
Mohamad Fawzi Mahomoodally
Anahtar Kelimeler
Anti-cancer
Antioxidant
Anti-proliferative
Cholinesterases
DNA protection
α-glucosidase
Kurumlar
Faculdade de Ciências da Universidade de Lisboa
Lisbon Portugal
Kastamonu University
Kastamonu Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Universidade do Algarve
Faro Portugal
University of G. d'Annunzio Chieti and Pescara
Chieti Italy
University of Mauritius
Reduit Mauritius
Scimago Dergi (ISSN Eşleşmesi)
Food and Chemical Toxicology
Q1
SJR Skoru0,750
H-Index223
YayıncıElsevier Ltd
ÜlkeUnited Kingdom
Food Science (Q1)
Medicine (miscellaneous) (Q2)
Toxicology (Q2)
Metrikler
51
Atıf
10
Yazar
6
Anahtar Kelime