Scopus
YÖKSİS DOI Eşleşti
SJR Q3
Phenolic composition, antioxidant and cytotoxic prospective of three linum species: A potential source of novel anticancer pharmacophores
Current Organic Chemistry · Ocak 2018
YÖKSİS Kayıtları
Phenolic Composition, Antioxidant and Cytotoxic Prospective of three Linum species: A Potential Source of Novel Anticancer Pharmacophores
CURRENT ORGANIC CHEMISTRY · 2018 SCI-Expanded
Prof. Dr. GÖKHAN ZENGİN →
Phenolic Composition, Antioxidant and Cytotoxic Prospective of three Linum species: A Potential Source of Novel Anticancer Pharmacophores
CURRENT ORGANIC CHEMISTRY · 2018 SCI-Expanded
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Calixarenes in Lipase Biocatalysis and Cancer Therapy
2016 ISSN: 13852728 SCI-Expanded
Prof. Dr. SERDAR KARAKURT →
Calixarenes in Lipase Biocatalysis and Cancer Therapy
2016 ISSN: 13852728 SCI-Expanded
Prof. Dr. MUSTAFA YILMAZ →
Phenolic Compounds, Antioxidant Properties and Enzyme Inhibition Ability of Adiantum capillus veneris L. linked to Alzheimer’s Disease, Diabetes Mellitus and Skin Disorders
2018 ISSN: 1385-2728 SCI
Prof. Dr. GÖKHAN ZENGİN →
Phenolic Composition, Antioxidant and Cytotoxic Prospective of three Linum species: A Potential Source of Novel Anticancer Pharmacophores
2018 ISSN: 1385-2728 SCI-Expanded
Prof. Dr. GÖKHAN ZENGİN →
Makale Bilgileri
ISSN13852728
Yayın TarihiOcak 2018
Cilt / Sayfa22 · 1690-1696
Scopus ID2-s2.0-85056755050
Özet
The therapeutic potential of some Linum species has been reported previously. Nonetheless, several species of this genus warrant further scientific consideration. In this study, the phenolic composition, antioxidant activity (DPPH, phosphomolybdenum, iron chelating, hydroxyl radical and lipid peroxidation assays) and cytotoxicity effect (human rhabdomyosarcoma, human cervix carcinoma, and murine fibroblast cell lines) of ethyl acetate, methanol, and water extracts of three Linum species (Linum austriacum subsp. glaucescens, Linum hirsutum subsp. anatolicum, and Linum tenuifolium) were assessed. High performance liquid chromatography with diode-array detection (HPLC-DAD) analysis revealed the presence of ferulic acid, p-hydroxybenzoic acid, synapic acid, rutin, apigenin-glucoside, quercetin, luteolin, and naringenin in all the extracts. It was observedthat the extracts (IC50 ranging from 42.07 to 51.66 µ g/mL) showed IC50 significantly (p<0.05) lower than ascorbic and gallic acid (> 1000 and 255.43 µ g/mL respectively) against lipid peroxidation. According to the American National Cancer Institute guidelines, the extracts showed low cytotoxicity (IC50 < 30 µ g/mL). However, the water extracts showed cytotoxicity effects (IC50 17.43±0.13 to 28.12±0.66 µ g/mL) against the studied cell lines as compared to the antineoplastic positive control (Cis-DDP). These findings support the use of these plants in the management of ROS mediated disorders and advocates for the need for further scientific evaluations to confirm the observed in vitro bioactivity. The cytotoxic potential coupled with the antioxidant property of the water extracts of these plant species is of particular interest which can open new avenues in the quest for novel anticancer drugs.
Yazarlar (6)
1
Gokhan Zengin
ORCID: 0000-0001-6548-7823
2
Carene Marie Nancy Picot-Allain
3
Abdurrahman Aktumsek
4
Pavle Mašković
5
Jelena M. Vujić
6
Mohamad Fawzi Mahomoodally
Anahtar Kelimeler
Anticancer
Antioxidant
Cytotoxic
Linum
Nutraceuticals
Phenolic
Turkey
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
University of Kragujevac
Kragujevac Serbia
University of Mauritius
Reduit Mauritius
Scimago Dergi (ISSN Eşleşmesi)
Current Organic Chemistry
Q3
SJR Skoru0,356
H-Index115
YayıncıBentham Science Publishers
ÜlkeUnited Arab Emirates
Organic Chemistry (Q3)
Metrikler
5
Atıf
6
Yazar
7
Anahtar Kelime