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In vitro and in silico perspectives on biological and phytochemical profile of three halophyte species—A source of innovative phytopharmaceuticals from nature

Phytomedicine · Ocak 2018

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YÖKSİS Kayıtları
In vitro and in silico perspectives on biological and phytochemical profile of three halophyte species—A source of innovative phytopharmaceuticals from nature
Phytomedicine · 2018 SCI-Expanded
Prof. Dr. GÖKHAN ZENGİN →
YÖKSİS ISSN Eşleşmesi

Bu dergide (ISSN eşleşmesi) kurumun 9 kaydı bulundu.

YÖKSİS Kayıtları — ISSN Eşleşmesi
Protective effects of curcumin supplementation on intestinal ischemia reperfusion injury
2013 ISSN: 09447113 SSCI
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Chemical and Biological Insights on Cotoneaster integerrimus A new epicatechin source for food and medicinal applications
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Chemical and biological insights on Cotoneaster integerrimus A new epicatechin source for food and medicinal applications
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Protective effects of curcumin supplementation on intestinal ischemiareperfusion injury
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Chemical and biological insights on Cotoneaster integerrimus A new epicatechin source for food and medicinal applications
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Dr. Öğr. Üyesi ERDOĞAN GÜNEŞ →
In vitro and in silico perspectives on biological and phytochemical profile of three halophyte species—A source of innovative phytopharmaceuticals from nature
2018 ISSN: 0944-7113 SCI-Expanded
Prof. Dr. GÖKHAN ZENGİN →
Determination of 1-Deoxynojirimycin by a developed and validated HPLC-FLD method and assessment of In-vitro antioxidant, α-Amylase and α-Glucosidase inhibitory activity in mulberry varieties from Turkey
2019 ISSN: 0944-7113 SCI-Expanded
Prof. Dr. NURANİYE ERUYGUR →
Mechanisms of action of cytotoxic phenolic compounds from Glycyrrhiza iconica roots
2019 ISSN: 0944-7113 SCI-Expanded
Prof. Dr. YÜKSEL KAN →
Mechanisms of action of cytotoxic phenolic compounds from Glycyrrhiza iconica roots
2019 ISSN: 0944-7113 SCI
Prof. Dr. YÜKSEL KAN →

Makale Bilgileri

Dergi Phytomedicine
ISSN09447113
Yayın TarihiOcak 2018
Cilt / Sayfa38 · 35-44
DOI10.1016/j.phymed.2017.10.017
Scopus ID2-s2.0-85032898909
Özet Background Halophytes are considered as valuable sources of traditional drugs in different countries. Purpose The present study aimed to evaluate biological and chemical fingerprints of three halophytes (Arthrocnemum macrostachyum (Moric.) C, Koch, Halimione portulacoides (L.) Aellen and Salicornia europaea L.). Materials and methods The antioxidant and enzymatic inhibitory potential (acetylcholinesterase, butyrylcholinesterase, α-amylase, α-glucosidase, and tyrosinase) were assessed. The total phenolic, flavonoid contents, and the chemical profiles were appraised using the ultra-high performance liquid chromatography-electrospray ionization-tandem mass spectrometry. Molecular docking was conducted to provide additional insights of molecular interactions of the enzymes/phytochemicals. Results Ethyl acetate extract was the most efficient extract, with A. macrostachyum being the most potent towards DPPH and ABTS radicals and phosphomolybdenum assay. Ethyl acetate extract of A. macrostachyum was also the best reducing agent (CUPRAC and FRAP assays). Methanol and ethyl acetate extract of A. macrostachyum, H. portulacoides, and S. europaea showed significant enzyme inhibition potential. Ethyl acetate extract of A. macrostachyum showed the highest total phenolic (29.54 ± 0.78 mgGAEs/g extract) while the ethyl acetate extract of S. europaea was more abundant in flavonoids (18.26 ± 0.11 mgREs/g extract). Phytochemical profiling allowed the identification of several components in the methanolic extracts (16 in A. macrostachyum, 14 in H. portulacoides, and 11 in S. europaea), with quinic acid, p-coumaric acid, and rhamnetin being most abundant. Docking studies revealed that the above compounds showed scores for the enzymes tested. Conclusion The three halophytes studies could be considered as potential sources of biologically-active compounds for novel phytopharmaceuticals development.

Yazarlar (5)

1
Gokhan Zengin
ORCID: 0000-0001-6548-7823
2
Zaahira Aumeeruddy-Elalfi
3
Adriano Mollica
4
Mustafa Abdullah Yılmaz
5
Mohamad Fawzi Mahomoodally

Anahtar Kelimeler

Enzymatic inhibition Halophytes Molecular dockings Natural products UHPLC-ESI-MS/MS

Kurumlar

Dicle Üniversitesi
Diyarbakir Turkey
Selçuk Üniversitesi
Selçuklu Turkey
University of G. d'Annunzio Chieti and Pescara
Chieti Italy
University of Mauritius
Reduit Mauritius
Scimago Dergi (ISSN Eşleşmesi)
Phytomedicine
Q1
SJR Skoru2,092
H-Index160
YayıncıElsevier GmbH
ÜlkeGermany
Complementary and Alternative Medicine (Q1)
Drug Discovery (Q1)
Molecular Medicine (Q1)
Pharmaceutical Science (Q1)
Pharmacology (Q1)
Dergi sayfasına git

Metrikler

70
Atıf
5
Yazar
5
Anahtar Kelime

Sistemimizdeki Yazarlar

GZ
GÖKHAN ZENGİN
Prof. Dr.

Hızlı Erişim

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