Scopus
YÖKSİS Eşleşti
Enzyme inhibitory and antioxidant activities of Nerium oleander L. flower extracts and activity guided isolation of the active components
Industrial Crops and Products · Şubat 2018
YÖKSİS Kayıtları
Enzyme inhibitory and antioxidant activities of Nerium oleander L. flower extracts and activity guided isolation of the active components
Industrial Crops and Products · 2018 SCI-Expanded
PROFESÖR GÖKHAN ZENGİN →
Enzyme inhibitory and antioxidant activities of Nerium oleander L. flower extracts and activity guided isolation of the active components
Industrial Crops and Products · 2018 SCI-Expanded
PROFESÖR GÖKHAN ZENGİN →
Enzyme inhibitory and antioxidant activities of Nerium oleander L. flower extracts and activity guided isolation of the active components
INDUSTRIAL CROPS AND PRODUCTS · 2018 SCI
PROFESÖR GÖKHAN ZENGİN →
Makale Bilgileri
DergiIndustrial Crops and Products
Yayın TarihiŞubat 2018
Cilt / Sayfa112 · 24-31
Scopus ID2-s2.0-85032945978
Özet
Oleander (Nerium oleander L., fam: Apocynaceae) is an evergreen shrub. Although it is known to be poisonous to humans, a large number of utilizations in folk medicine have been reported against diabetes, rheumatic pain and skin diseases. The present study aimed to investigate the cholinesterase inhibitory activities of oleander flower extracts and to isolate the active components responsible for the activity. The antidiabetic and skin care effects were also determined on some key enzymes (α-glucosidase, α-amylase, tyrosinase). The flower extracts obtained with aqueous, polar and apolar organic solvents were evaluated for their phenolic contents and antioxidant capacities. The enzyme inhibitory activities (cholinesterase, α-glucosidase, α-amylase and tyrosinase) were examined by microtiter plate assays. Antioxidant properties were evaluated by DPPH, FRAP and CUPRAC assays. Total phenolic and flavonoid contents were determined using the Folin-Ciocalteu reagent and aluminum chloride, respectively. The structures of the isolates were elucidated by NMR and MS experiments.In the present study, cholinesterase inhibitory activity of the EtOH extract of the olaender flowers was investigated and β-sitosterol and oleanolic acid were isolated as the active components. The less polar extracts (n-hexane) exerted better cholinesterase and α-amylase inhibitory activities than those of the more polar extracts (R-H2O, EtOAc) which had better α-glucosidase and tyrosinase activities. The highest antioxidant capacity values were obtained from EtOAc and EtOH extracts. The EtOH extract was found to contain the highest levels of total phenolic and flavonoid contents. The results suggest that the flowers of oleander could be a potential source for high value phytochemicals for developing novel drug leads.
Yazarlar (8)
1
İrem Atay Balkan
2
Hacer Tuğba Doğan
3
Gokhan Zengin
ORCID: 0000-0001-6548-7823
4
Nesrin Colak
5
Faik Ahmet Ayaz
6
Ahmet C. Gören
ORCID: 0000-0002-5470-130X
7
Hasan Kırmızıbekmez
8
Erdem Yesilada
Anahtar Kelimeler
Antioxidant
Enzyme inhibitory
Nerium oleander
Oleander
Oleanolic acid
β-Sitosterol
Kurumlar
İstanbul Medipol Üniversitesi
Istanbul Turkey
Karadeniz Technical University
Trabzon Turkey
Selçuk Üniversitesi
Selçuklu Turkey
TÜBİTAK Ulusal Metroloji Enstitüsü
Gebze Turkey
University of Health Sciences
Istanbul Turkey
Yeditepe University
Istanbul Turkey
Metrikler
27
Atıf
8
Yazar
6
Anahtar Kelime