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In vitro and in silico evaluation of Centaurea saligna (K.Koch) Wagenitz—An endemic folk medicinal plant

Computational Biology and Chemistry · Nisan 2018

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YÖKSİS Kayıtları
In vitro and in silico evaluation of Centaurea saligna (K.Koch) Wagenitz—an endemic folk medicinal plant
COMPUTATIONAL BIOLOGY AND CHEMISTRY · 2018 SCI
Prof. Dr. GÖKHAN ZENGİN →
YÖKSİS ISSN Eşleşmesi

Bu dergide (ISSN eşleşmesi) kurumun 8 kaydı bulundu.

YÖKSİS Kayıtları — ISSN Eşleşmesi
In vitro and in silico evaluation of Centaurea saligna (K.Koch) Wagenitz—an endemic folk medicinal plant
2018 ISSN: 1476-9271 SCI
Prof. Dr. GÖKHAN ZENGİN →
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Multifunctional approaches to provide potential pharmacophores for the pharmacy shelf: Heracleum sphondylium L. subsp. ternatum (Velen.) Brummitt.
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HPLC-DAD profiles and pharmacological insights of Onobrychis argyrea subsp isaurica extracts
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Multi-targeted potential of Pittosporum senacia Putt.: HPLC-ESI-MSn analysis, in silico docking, DNA protection, antimicrobial, enzyme inhibition, anti-cancer and apoptotic activity
2019 ISSN: 1476-9271 SCI-Expanded
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Chemical characterization, computational analysis and biological views on Daphne gnidioides Jaub. Spach extracts: Can a new raw material be provided for biopharmaceutical applications?
2020 ISSN: 1476-9271 SCI-Expanded
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Chemical characterization, computational analysis and biological views on Daphne gnidioides Jaub. Spach extracts: Can a new raw material be provided for biopharmaceutical applications?
2020 ISSN: 1476-9271 SCI-Expanded
Prof. Dr. GÖKHAN ZENGİN →
Computational analysis of natural compounds as potential phosphodiesterase type 5A inhibitors
2024 ISSN: 1476-9271 SCI-Expanded Q2
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Makale Bilgileri

Dergi Computational Biology and Chemistry
ISSN14769271
Yayın TarihiNisan 2018
Cilt / Sayfa73 · 120-126
DOI10.1016/j.compbiolchem.2018.02.010
Scopus ID2-s2.0-85042492354
Özet Centaurea saligna (K.Koch) Wagenitz is an endemic plant used in Turkish folk medicine as antibacterial, tonic, astringent, choleretic, anti-rheumatic, diuretic, and antipyretic. This study attempts for the first time to assess the possible enzyme inhibitory potential, antioxidant activity, and determine the phytochemical profile of the ethyl acetate, methanol, and water extracts of C. saligna. The water extract had the highest phenolic content (30.18 mg GAE/g extract) and the most potent oxidant scavenging activity ((120.53, 111.90, 68.43, and 157.88 mg TE/g extract, for CUPRAC [cupric reducing antioxidant capacity], FRAP [ferric reducing antioxidant power], DPPH [2,2-diphenyl-1-picrylhydrazyl], and ABTS [2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid] assays respectively)). The water extract (4.16 mg KAE/g extract) also inhibited tyrosinase and contained high level of catechin (214 μg/g extract). Ethyl acetate extract showed potent inhibitory capacity against cholinesterases (2.22 and 2.21 mg GALAE/g extract for acetyl and butyryl cholinesterase, respectively) and α-glucosidase (23.80 mmol ACAE/g extract). High concentration of apigenin (2472 μg/g extract) was identified in the ethyl acetate extract. In silico studies showed that apigenin binds to the enzymatic pocket of α-glucosidase and is stabilised by a network of hydrogen bonds and pi-pi stacking. Data collected in the present study advocates the need for further investigation geared towards validation of C. saligna for the management of complications related to the target enzymes, such as diabetes type II, Alzheimer's disease, and epidermal hyperpigmentation.

Yazarlar (5)

1
Gokhan Zengin
ORCID: 0000-0001-6548-7823
2
Gizem Bulut
3
Adriano Mollica
4
Carene Marie Nancy Picot-Allain
5
Mohamad Fawzi Mahomoodally

Anahtar Kelimeler

Antioxidants Bioactive compounds Centaurea saligna Enzyme inhibitors Folk medicine

Kurumlar

Marmara Üniversitesi
Istanbul Turkey
Selçuk Üniversitesi
Selçuklu Turkey
University of G. d'Annunzio Chieti and Pescara
Chieti Italy
University of Mauritius
Reduit Mauritius
Scimago Dergi (ISSN Eşleşmesi)
Computational Biology and Chemistry
Q2
SJR Skoru0,561
H-Index76
YayıncıElsevier Ltd
ÜlkeUnited Kingdom
Computational Mathematics (Q2)
Organic Chemistry (Q2)
Biochemistry (Q3)
Structural Biology (Q3)
Dergi sayfasına git

Metrikler

49
Atıf
5
Yazar
5
Anahtar Kelime

Sistemimizdeki Yazarlar

GZ
GÖKHAN ZENGİN
Prof. Dr.

Hızlı Erişim

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