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UHPLC-QTOF-MS analysis of bioactive constituents from two Romanian Goji (Lycium barbarum L.) berries cultivars and their antioxidant, enzyme inhibitory, and real-time cytotoxicological evaluation

Food and Chemical Toxicology · Mayıs 2018

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YÖKSİS Kayıtları
UHPLC-QTOF-MS analysis of bioactive constituents from two Romanian Goji (Lycium barbarum L.) berries cultivars and their antioxidant, enzyme inhibitory, and real-time cytotoxicological evaluation
FOOD AND CHEMICAL TOXICOLOGY · 2018 SCI
Prof. Dr. GÖKHAN ZENGİN →
YÖKSİS ISSN Eşleşmesi

Bu dergide (ISSN eşleşmesi) kurumun 20 kaydı bulundu.

YÖKSİS Kayıtları — ISSN Eşleşmesi
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UHPLC-QTOF-MS analysis of bioactive constituents from two Romanian Goji (Lycium barbarum L.) berries cultivars and their antioxidant, enzyme inhibitory, and real-time cytotoxicological evaluation
2018 ISSN: 0278-6915 SCI
Prof. Dr. GÖKHAN ZENGİN →
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Makale Bilgileri

Dergi Food and Chemical Toxicology
ISSN02786915
Yayın TarihiMayıs 2018
Cilt / Sayfa115 · 414-424
DOI10.1016/j.fct.2018.01.054
Scopus ID2-s2.0-85042725891
Özet Goji (Lycium barbarum L.) berries are emphasized as healthy food or are used widely as dietary supplements. In the present study, the antioxidant and enzyme inhibitory activities of berries extracts from two selected Romanian cultivars (cv. Erma and cv. Biglifeberry) have been evaluated. UHPLC-QTOF-MS analysis results revealed the presence of organic acids, phenolic acids, flavonoids, fatty acids (oxylipins), and spermidine derivatives. In particular, cv. Erma showed an important tyrosinase-inhibitory effect, whereas, cv. Biglifeberry had a superior antioxidant capacity. Particularly, results provided by the CUPRAC assay showed the highest antioxidant capacity values (26.91 mg TE/g and 35.41 mg TE/g, for ‘Erma’ and ‘Biglifeberry’ respectively). Toxicological properties of the extracts were evaluated with human embryonic kidney cells (HEK-293) using the cytotoxicity analysis platform iCELLigence, real-time and label-free impedance technology. No cytotoxic effects were observed in a time- and dose-dependent manner. Overall, Goji berries are a rich source of bioactive compounds with functional properties that need further risk/benefit evaluation when used in foods or health-promoting formulations.

Yazarlar (10)

1
Andrei Mocan
2
Cadmiel Moldovan
3
Gokhan Zengin
ORCID: 0000-0001-6548-7823
4
Onur Bender
ORCID: 0000-0003-0691-3508
5
Marcello Locatelli
ORCID: 0000-0002-0840-825X
6
Mario Simirgiotis
7
Arzu Atalay
ORCID: 0000-0003-1309-5291
8
Dan C. Vodnar
9
Sascha Rohn
10
Gianina Crişan

Anahtar Kelimeler

Biological activities Chemical profile Cytotoxic effects Goji cultivars UHPLC-QTOF xCELLigence

Kurumlar

Ankara Üniversitesi
Ankara Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Universidad Austral de Chile
Valdivia Chile
Universitatea de Medicina si Farmacie Iuliu Hatieganu din Cluj-Napoca
Cluj Napoca Romania
Universitatea de Stiinte Agricole si Medicina Veterinara din Cluj-Napoca
Cluj Napoca Romania
Universität Hamburg
Hamburg Germany
University of G. d'Annunzio Chieti and Pescara
Chieti Italy
Scimago Dergi (ISSN Eşleşmesi)
Food and Chemical Toxicology
Q1
SJR Skoru0,750
H-Index223
YayıncıElsevier Ltd
ÜlkeUnited Kingdom
Food Science (Q1)
Medicine (miscellaneous) (Q2)
Toxicology (Q2)
Dergi sayfasına git

Metrikler

99
Atıf
10
Yazar
6
Anahtar Kelime

Sistemimizdeki Yazarlar

GZ
GÖKHAN ZENGİN
Prof. Dr.

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