Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Integration of in vitro and in silico perspectives to explain chemical characterization, biological potential and anticancer effects of Hypericum salsugineum: A pharmacologically active source for functional drug formulations
PLoS ONE · Haziran 2018
YÖKSİS Kayıtları
Integration of in vitro and in silico perspectives to explain chemical characterization, biological potential and anticancer effects of Hypericum salsugineum: A pharmacologically active source for functional drug formulations
PLOS ONE · 2018 SCI
PROFESÖR GÖKHAN ZENGİN →
Makale Bilgileri
DergiPLoS ONE
Yayın TarihiHaziran 2018
Cilt / Sayfa13
Scopus ID2-s2.0-85048110741
Erişim🔓 Açık Erişim
Özet
The genus Hypericum is one of the most popular genera in both traditional medicine and scientific platform. This study is designed to provide conceptual insights on the biological potential and chemical characterization of H. salsugineum, which is endemic to Turkey. The qualitative and quantitative phenolic content of the extracts was characterized by HPLC-ESI-MSn. Biological efficiency was investigated by enzyme inhibitory assays (cholinesterases, tyrosinase, amylase, and glucosidase) and anti-cancer efficacy tests (anti-proliferative activities with the iCELLigence technology, colony formation and wound healing scratch assays). Phenolic acids (3-O-caffeoylquinic, 5-O-caffeoylquinic, and 4-O-caffeoylquinic acids) were the predominant group in the studied extracts, although several flavonoids were also detected and quantified. The extracts exhibited good inhibitory effects on tyrosinase and glucosidase, while they had weak ability against cholinesterases and amylase. Computational studies were also performed to explain the interactions between the major phenolics and these enzymes. The extracts displayed significant anti-cancer effects on breast carcinoma cell lines. Our findings suggest that Hypericum salsugineum could be valued as a potential source of biologically-active compounds for designing novel products.
Yazarlar (8)
1
Onur Bender
ORCID: 0000-0003-0691-3508
2
E. J. Llorent-Martínez
3
Gokhan Zengin
ORCID: 0000-0001-6548-7823
4
Adriano Mollica
5
Ramazan Ceylan
6
Lucía Molina-García
7
Maria Luisa Fernández De Córdova
8
Arzu Atalay
ORCID: 0000-0003-1309-5291
Kurumlar
Ankara Üniversitesi
Ankara Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Universidad de Jaén
Jaen Spain
University of G. d'Annunzio Chieti and Pescara
Chieti Italy
Metrikler
32
Atıf
8
Yazar