Scopus
Evaluation of the therapeutic effects of Artemisia absinthium L. on pseudopregnancy model in rats
Phytochemistry Reviews · Ağustos 2018
Makale Bilgileri
DergiPhytochemistry Reviews
Yayın TarihiAğustos 2018
Cilt / Sayfa17 · 937-946
Scopus ID2-s2.0-85045432093
Özet
Researchers have been investigating new treatment strategies for the management of pseudopregnancy, due to some long term causes of this disease including mastitis and mammary tumor. Owing to the side effects of hormone therapy, much attention has been focused on more tolerable treatment options including natural remedies. In the present study, we aimed to investigate the therapeutic effects of Artemisia absinthium L. (wormwood) on pseudopregnancy model in rats. A. absinthium, which is a perennial shrubby plant from Asteraceae family, was reported to be used as an emmenagogue in folk medicine and was previously shown to modulate dopaminergic system. In the present study, pseudopregnancy model was induced in female Sprague–Dawley rats by injection of pregnant mare’s serum gonadotropin and human chorionic gonadotropin. The petroleum ether, dichloromethane and methanol extracts of A. absinthium, prepared by successive extraction method, were orally administered to the rats at 100 mg/kg dose, once daily for 10 days. Bromocriptine (3 mg/kg/per os) was administered to the reference group animals. At the end of the experiment, all of the animals were sacrificed, the blood samples, ovaries and uterine tissues were taken for histopathological and biochemical analysis. According to the results of the present study, the petroleum ether extract displayed beneficial effects in pseudopregnancy model in rats when compared with the control group. Therefore, Gas Chromatography analysis was conducted on this extract to reveal its phytochemical profile.
Yazarlar (5)
1
Mürşide Ayşe Demirel
2
Ipek Süntar
ORCID: 0000-0003-4201-1325
3
Songul Ceribaşı
4
Gokhan Zengin
ORCID: 0000-0001-6548-7823
5
Ali Osman Ceribaşı
Anahtar Kelimeler
Artemisia absinthium
Asteraceae
Dopaminergic
Pseudopregnancy
Rat
Kurumlar
Firat Üniversitesi
Elazig Turkey
Gazi Üniversitesi
Ankara Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
2
Atıf
5
Yazar
5
Anahtar Kelime