Scopus
🔓 Açık Erişim
Multiple pharmacological approaches on Fibigia eriocarpa extracts by in vitro and computational assays
Fundamental and Clinical Pharmacology · Ağustos 2018
Makale Bilgileri
DergiFundamental and Clinical Pharmacology
Yayın TarihiAğustos 2018
Cilt / Sayfa32 · 400-413
Scopus ID2-s2.0-85046135239
Erişim🔓 Açık Erişim
Özet
The ethyl acetate, methanolic, and water extracts of Fibigia eriocarpa were assessed for a panoply of bioactivities. Total phenolic and flavonoid content were quantified as well as individual phenolic compounds by HPLC-DAD. The in vitro antioxidant and enzyme (acetylcholinesterase (AChE), butyrylcholinesterase (BChE), tyrosinase, α-amylase, and α-glucosidase) inhibitory potential of the extracts were evaluated. In silico molecular docking was used to investigate possible interaction between dominant compounds and selected enzymes. Vanillin (303 μg/g extract), apigenin (270 μg/g extract), and kaempferol (180 μg/g extract) were the main compounds in the ethyl acetate extract, while the methanolic extract was characterized by the presence of vanillin, rutin, and apigenin (616, 616 and 252 μg/g extract, respectively). (+)-catechin (1422 μg/g extract) was the main compound in the water extracts. The ethyl acetate extract was found to be a superior source of antioxidant compounds and enzyme inhibitors against above-mentioned enzymes. Docking studies revealed that p-hydroxybenzoic and (+)-catechin have the best scores for tyrosinase, while kaempferol and apigenin showed the best binding pose for α-glucosidase, AChE, and BChE. Results amassed herein are the first report on the phytochemical and biological attributes of F. eriocarpa, which tend to validate the pharmacological uses of this plant as an alternative medicine.
Yazarlar (6)
1
Gokhan Zengin
ORCID: 0000-0001-6548-7823
2
Devina Lobine
3
Adriano Mollica
4
Marcello Locatelli
ORCID: 0000-0002-0840-825X
5
Simone Carradori
6
Mohamad Fawzi Mahomoodally
Anahtar Kelimeler
antioxidant
bioactive compounds
Fibigia
molecular docking
natural enzyme inhibitors
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
University of G. d'Annunzio Chieti and Pescara
Chieti Italy
University of Mauritius
Reduit Mauritius
Metrikler
10
Atıf
6
Yazar
5
Anahtar Kelime