Scopus
YÖKSİS Eşleşti
New insights into the in vitro biological effects, in silico docking and chemical profile of clary sage – Salvia sclarea L.
Computational Biology and Chemistry · Ağustos 2018
YÖKSİS Kayıtları
New insights into the in vitro biological effects, in silico docking and chemical profile of clary sage – Salvia sclarea L.
COMPUTATIONAL BIOLOGY AND CHEMISTRY · 2018 SCI-Expanded
PROFESÖR GÖKHAN ZENGİN →
Makale Bilgileri
DergiComputational Biology and Chemistry
Yayın TarihiAğustos 2018
Cilt / Sayfa75 · 111-119
Scopus ID2-s2.0-85047076595
Özet
Salvia sclarea L. is traditionally used to manage common human ailments and is consumed as a food product. This study aimed to establish the phytochemical profile and antioxidant potential of ethyl acetate, methanol, and water extracts of Salvia sclarea. The inhibitory action of the extracts against α-amylase, α-glucosidase, acetylcholinesterase, butyrylcholinesterase, and tyrosinase was also investigated. Methanol extract showed the highest phenolic and flavonoid contents (81.78 mg GAE/g extract and 40.59 mg RE/g extract, respectively). Reversed phase high performance liquid chromatography with diode array detector analysis revealed that S. sclarea was rich in rosmarinic acid. The water extract exhibited the lowest inhibitory activity against α-amylase but the upmost activity against α-glucosidase (0.19 and 18.24 mmol ACAE/g extract, respectively). Experimental data showed that only the water extract (8.86 mg KAE/g extract) significantly inhibited tyrosinase. Docking studies showed that quercetin binds to tyrosinase by two hydrogen and a pi-pi bonds. Salvia sclarea showed interesting biological activity against key enzymes involved in the pathogenesis of common ailments.
Yazarlar (7)
1
Gokhan Zengin
ORCID: 0000-0001-6548-7823
2
Ismail Senkardes
3
Adriano Mollica
4
Carene Marie Nancy Picot-Allain
5
Gizem Bulut
6
Ahmet Dogan
7
Mohamad Fawzi Mahomoodally
Anahtar Kelimeler
Clary sage
Molecular docking
Natural enzyme inhibitors
Salvia
Kurumlar
Marmara Üniversitesi
Istanbul Turkey
Selçuk Üniversitesi
Selçuklu Turkey
University of G. d'Annunzio Chieti and Pescara
Chieti Italy
University of Mauritius
Reduit Mauritius
Metrikler
50
Atıf
7
Yazar
4
Anahtar Kelime