Scopus
YÖKSİS DOI Eşleşti
SJR Q2
New insights into the in vitro biological effects, in silico docking and chemical profile of clary sage – Salvia sclarea L.
Computational Biology and Chemistry · Ağustos 2018
YÖKSİS Kayıtları
New insights into the in vitro biological effects, in silico docking and chemical profile of clary sage – Salvia sclarea L.
COMPUTATIONAL BIOLOGY AND CHEMISTRY · 2018 SCI-Expanded
Prof. Dr. GÖKHAN ZENGİN →
YÖKSİS Kayıtları — ISSN Eşleşmesi
In vitro and in silico evaluation of Centaurea saligna (K.Koch) Wagenitz—an endemic folk medicinal plant
2018 ISSN: 1476-9271 SCI
Prof. Dr. GÖKHAN ZENGİN →
New insights into the in vitro biological effects, in silico docking and chemical profile of clary sage – Salvia sclarea L.
2018 ISSN: 1476-9271 SCI-Expanded
Prof. Dr. GÖKHAN ZENGİN →
Multifunctional approaches to provide potential pharmacophores for the pharmacy shelf: Heracleum sphondylium L. subsp. ternatum (Velen.) Brummitt.
2019 ISSN: 1476-9271 SCI
Prof. Dr. AHMET UYSAL →
HPLC-DAD profiles and pharmacological insights of Onobrychis argyrea subsp isaurica extracts
2018 ISSN: 1476-9271 SCI
Prof. Dr. GÖKHAN ZENGİN →
Multi-targeted potential of Pittosporum senacia Putt.: HPLC-ESI-MSn analysis, in silico docking, DNA protection, antimicrobial, enzyme inhibition, anti-cancer and apoptotic activity
2019 ISSN: 1476-9271 SCI-Expanded
Prof. Dr. GÖKHAN ZENGİN →
Chemical characterization, computational analysis and biological views on Daphne gnidioides Jaub. Spach extracts: Can a new raw material be provided for biopharmaceutical applications?
2020 ISSN: 1476-9271 SCI-Expanded
Prof. Dr. GÖKHAN ZENGİN →
Chemical characterization, computational analysis and biological views on Daphne gnidioides Jaub. Spach extracts: Can a new raw material be provided for biopharmaceutical applications?
2020 ISSN: 1476-9271 SCI-Expanded
Prof. Dr. GÖKHAN ZENGİN →
Computational analysis of natural compounds as potential phosphodiesterase type 5A inhibitors
2024 ISSN: 1476-9271 SCI-Expanded Q2
Prof. Dr. GÖKHAN ZENGİN →
Makale Bilgileri
ISSN14769271
Yayın TarihiAğustos 2018
Cilt / Sayfa75 · 111-119
Scopus ID2-s2.0-85047076595
Özet
Salvia sclarea L. is traditionally used to manage common human ailments and is consumed as a food product. This study aimed to establish the phytochemical profile and antioxidant potential of ethyl acetate, methanol, and water extracts of Salvia sclarea. The inhibitory action of the extracts against α-amylase, α-glucosidase, acetylcholinesterase, butyrylcholinesterase, and tyrosinase was also investigated. Methanol extract showed the highest phenolic and flavonoid contents (81.78 mg GAE/g extract and 40.59 mg RE/g extract, respectively). Reversed phase high performance liquid chromatography with diode array detector analysis revealed that S. sclarea was rich in rosmarinic acid. The water extract exhibited the lowest inhibitory activity against α-amylase but the upmost activity against α-glucosidase (0.19 and 18.24 mmol ACAE/g extract, respectively). Experimental data showed that only the water extract (8.86 mg KAE/g extract) significantly inhibited tyrosinase. Docking studies showed that quercetin binds to tyrosinase by two hydrogen and a pi-pi bonds. Salvia sclarea showed interesting biological activity against key enzymes involved in the pathogenesis of common ailments.
Yazarlar (7)
1
Gokhan Zengin
ORCID: 0000-0001-6548-7823
2
Ismail Senkardes
3
Adriano Mollica
4
Carene Marie Nancy Picot-Allain
5
Gizem Bulut
6
Ahmet Dogan
7
Mohamad Fawzi Mahomoodally
Anahtar Kelimeler
Clary sage
Molecular docking
Natural enzyme inhibitors
Salvia
Kurumlar
Marmara Üniversitesi
Istanbul Turkey
Selçuk Üniversitesi
Selçuklu Turkey
University of G. d'Annunzio Chieti and Pescara
Chieti Italy
University of Mauritius
Reduit Mauritius
Scimago Dergi (ISSN Eşleşmesi)
Computational Biology and Chemistry
Q2
SJR Skoru0,561
H-Index76
YayıncıElsevier Ltd
ÜlkeUnited Kingdom
Computational Mathematics (Q2)
Organic Chemistry (Q2)
Biochemistry (Q3)
Structural Biology (Q3)
Metrikler
57
Atıf
7
Yazar
4
Anahtar Kelime