Scopus
Phytochemical analysis and biological evaluation of three selected Cordia species from Panama
Industrial Crops and Products · Eylül 2018
Makale Bilgileri
DergiIndustrial Crops and Products
Yayın TarihiEylül 2018
Cilt / Sayfa120 · 84-89
Scopus ID2-s2.0-85046095067
Özet
The aim of the present study was the phytochemical analysis of the leaves from three not previously studied tropical species Cordia bicolor, Cordia megalantha and Cordia dentata (Boraginaceae) collected from Panama. The genus Cordia is one of the major and most important of the family and involves a wide range of therapeutic uses in traditional medicine. Eleven known compounds allantoin (1), rosmarinic acid (2), caffeic acid (3), isoquercetin (4), rutin (5), quercetin-3-Ο-β-D-neohesperidoside (6), kaempferol 3-Ο-β-D-neohesperidoside (7), helichrysoside (8), kaempferol 3-O-(2″-O-α-L-rhamnosyl-6″trans-p-coumaroyl)-β-D-glucoside (9), quercetin 3-O-(6″ trans-p-coumaroyl)-β-D-galactoside (10), 4-hydroxyphenyl lactic acid (11), have been isolated and structurally elucidated. Compounds 6 and 7 have been isolated for the first time in Cordia genus, compounds 8-10 are reported for the first time in the Boraginaceae family, while secondary metabolite 9 is isolated as natural product for the second time. The methanolic extracts of the plants have been assayed for their antioxidant properties by free radical scavenging, reducing power, phosphomolybdenum and metal chelating assay. Enzyme inhibitory activity has been also evaluated against cholinesterases, α-amylase and α-glucosidase. C. megalantha exhibited the strongest antioxidant activity compared to the other studied Cordia species and a high inhibitory activity against α-glucosidase, which suggests that this herbal material could be used for further studies as a potential source for therapeutic applications.
Yazarlar (6)
1
Georgia Marini
2
Konstantia Graikou
ORCID: 0000-0001-6648-558X
3
Gokhan Zengin
ORCID: 0000-0001-6548-7823
4
George Albert Karikas
ORCID: 0000-0001-8583-5258
5
Mahabir P. Gupta
6
Ioanna Chinou
Anahtar Kelimeler
Antioxidant activity
Boraginaceae
Cordia
Enzyme inhibitory activity
Flavonol glucosides
Phenolics
Kurumlar
National and Kapodistrian University of Athens
Athens Greece
Selçuk Üniversitesi
Selçuklu Turkey
Universidad de Panamá
Panama City Panama
University of West Attica
Athens Greece
Metrikler
19
Atıf
6
Yazar
6
Anahtar Kelime