Scopus
YÖKSİS Eşleşti
Lotus aegaeus (Gris.) Boiss and Iberis sempervirens L.: Chemical fingerprints, antioxidant potential, and inhibition activities and docking on key enzymes linked to global health problems
Industrial Crops and Products · Eylül 2018
YÖKSİS Kayıtları
Lotus aegaeus (Gris.) Boiss and Iberis sempervirens L.: Chemical fingerprints, antioxidant potential, and inhibition activities and docking on key enzymes linked to global health problems
INDUSTRIAL CROPS AND PRODUCTS · 2018 SCI-Expanded
PROFESÖR GÖKHAN ZENGİN →
Lotus aegaeus (Gris.) Boiss and Iberis sempervirens L.: Chemical fingerprints, antioxidant potential, and inhibition activities and docking on key enzymes linked to global health problems
INDUSTRIAL CROPS AND PRODUCTS · 2018 SCI-Expanded
PROFESÖR ABDURRAHMAN AKTÜMSEK →
Makale Bilgileri
DergiIndustrial Crops and Products
Yayın TarihiEylül 2018
Cilt / Sayfa120 · 271-278
Scopus ID2-s2.0-85046135634
Özet
Natural products are gaining much momentum worldwide because they have a broad spectrum of biological effects and present excellent opportunities for bioproducts development. With this fact, this study has been designed to investigate for the first time the effects of the ethyl acetate (EA), methanolic (MeOH), and water (W) extracts of Lotus aegaeus (La) and Iberis sempervirens (Is) on key enzymes as well as to quantify antioxidant capacities. The total phenolic and flavonoid content were determined using colorimetric methods and the individual phenolic compounds were assessed by LC–MS/MS analysis. Quercetin hexoside was the dominant compound in L. aegaeus, particularly in methanol extract, while the ethyl acetate and methanol extracts of I. sempervirens were characterized by the presence scopoletin and hinic acid. The antioxidant abilities of the investigated extracts were tested using different assays including free radical scavenging, reducing power, phosphomolybdenum, and metal chelating. All the extracts showed strong antioxidant abilities. For both species, the ethyl acetate extracts were more potent against cholinesterases and α-amylase, while the methanol extracts were most active against α-glucosidase. Only the water extract, followed by methanol of I. sempervirens exhibited notable inhibitory activity against tyrosinase. In addition, the dominant compounds were docked against tyrosinase and α-glucosidase to investigate their predicted binding affinity and interactions with the active site. In conclusion, L. aegaeus and I. sempervirens showed potent biological attributes, which advocates for further studies to explore their potential use as phytopharmaceuticals.
Yazarlar (9)
1
Mohamad Fawzi Mahomoodally
2
Sanja Vlaisavljevic
3
Sanja Berežni
4
Hassan H. Abdallah
5
Gokhan Zengin
ORCID: 0000-0001-6548-7823
6
Atanas G. Atanasov
7
Adriano Mollica
8
Devina Lobine
9
Abdurrahman Aktumsek
Anahtar Kelimeler
Antioxidants
Enzyme inhibition
Medicinal plants
Molecular docking
Pharmaceuticals
Polyphenols
Kurumlar
Institute of Genetics and Animal Biotechnology of the Polish Academy of Sciences
Magdalenka Poland
Salahaddin University-Erbil
Erbil Iraq
Selçuk Üniversitesi
Selçuklu Turkey
Universität Wien
Vienna Austria
Universiti Sains Malaysia
Minden Malaysia
University of G. d'Annunzio Chieti and Pescara
Chieti Italy
University of Mauritius
Reduit Mauritius
University of Novi Sad
Novi Sad Serbia
Metrikler
15
Atıf
9
Yazar
6
Anahtar Kelime