Scopus
YÖKSİS Eşleşti
HPLC–MS/MS-based metabolic profiling and pharmacological properties of extracts and infusion obtained from Amelanchier parviflora var. dentata
Industrial Crops and Products · Kasım 2018
YÖKSİS Kayıtları
HPLC–MS/MS-based metabolic profiling and pharmacological properties of extracts and infusion obtained from Amelanchier parviflora var. dentata
INDUSTRIAL CROPS AND PRODUCTS · 2018 SCI-Expanded
PROFESÖR GÖKHAN ZENGİN →
Makale Bilgileri
DergiIndustrial Crops and Products
Yayın TarihiKasım 2018
Cilt / Sayfa124 · 699-706
Scopus ID2-s2.0-85052001055
Özet
Amelanchier parviflora var. dentata is an endemic medicinal plant traditionally consumed to treat stomach pain, cardiovascular diseases, and urinary tract infections in Turkey's folk medicine. Although Amelanchier genus is an excellent source of phytochemicals with a panoply of biological activities, no report has been made available on Amelanchier parviflora var. dentata. Thus, the metabolic profiles of methanol, ethyl acetate, and water extracts were obtained using HPLC–MS/MS. Besides, the pharmacological properties such as antioxidant activity and enzyme inhibition effects against acetyl/butyrylcholinesterase, tyrosinase, α-amylase, and α-glucosidase were evaluated. In total, 62, 38, and 16 metabolites were identified from the methanolic, water, and ethyl acetate extracts, respectively. The identified metabolites belong to anthocyanins, phenolic acids, and flavonoids. The tested extracts exhibited different enzyme inhibitory activity against cholinesterases (acetylcholinesterase: 0.52–2.47 mg GEs/g extract and butyrylcholinesterase: 0.47–3.59 mg GEs/g extract), tyrosinase (19.0–145.54 mg KAEs/g extract), α-amylase (0.23–1.10 mmol ACEs/g extract), and α-glucosidase (8.89–9.92 mmol ACEs/ g extract). Evidence from the present study supports the necessity for more research in an endeavor to discover biologically active secondary metabolites from A. parviflora to manage specific ailments.
Yazarlar (11)
1
Gokhan Zengin
ORCID: 0000-0001-6548-7823
2
Alina Diuzheva
ORCID: 0000-0003-2090-1634
3
József Jekő
4
Zoltán Cziáky
5
Gizem Bulut
6
Ahmet Dogan
7
Mehmet Zeki Haznedaroglu
8
Kannan RR Rengasamy
9
Devina Lobine
10
Mir Babak Bahadori
11
Mohamad Fawzi Mahomoodally
Anahtar Kelimeler
Amelanchier parviflora
Anthocyanins
Antioxidants
Chemical fingerprints
Enzyme inhibitors
Phenolics
Kurumlar
İzmir Kâtip Çelebi Üniversitesi
Izmir Turkey
Marmara Üniversitesi
Istanbul Turkey
Pavol Jozef Šafárik University in Košice
Kosice Slovakia
REEF Environmental Consultancy
Puducherry India
Research Center for Pharmaceutical Nanotechnology
Tabriz Iran
Selçuk Üniversitesi
Selçuklu Turkey
University of Mauritius
Reduit Mauritius
University of Nyíregyháza
Nyíregyháza Hungary
Metrikler
12
Atıf
11
Yazar
6
Anahtar Kelime