Scopus
YÖKSİS ISSN Eşleşti
SJR Q2
Combination of phenolic profiles, pharmacological properties and in silico studies to provide new insights on Silene salsuginea from Turkey
Computational Biology and Chemistry · Aralık 2018
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Chemical characterization, computational analysis and biological views on Daphne gnidioides Jaub. Spach extracts: Can a new raw material be provided for biopharmaceutical applications?
2020 ISSN: 1476-9271 SCI-Expanded
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Chemical characterization, computational analysis and biological views on Daphne gnidioides Jaub. Spach extracts: Can a new raw material be provided for biopharmaceutical applications?
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Computational analysis of natural compounds as potential phosphodiesterase type 5A inhibitors
2024 ISSN: 1476-9271 SCI-Expanded Q2
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Makale Bilgileri
ISSN14769271
Yayın TarihiAralık 2018
Cilt / Sayfa77 · 178-186
Scopus ID2-s2.0-85054873444
Özet
The genus Silene is renowned in Turkey for its traditional use as food and medicine. Currently, there are 138 species of Silene in Turkey, amongst which have been several studies for possible pharmacological potential and application in food industry. However, there is currently a paucity of data on Silene salsuginea Hub.-Mor. This study endeavours to access its antioxidant, enzyme inhibitory, and anti-inflammatory properties. Besides, reversed-phase high-performance liquid chromatography-diode array detector (RP-HPLC-DAD) was used to detect phenolic compounds, and molecular docking was performed to provide new insights for tested enzymes and phenolics. High amounts of apigenin (534 μg/g extract), ferulic acid (452 μg/g extract), p-coumaric acid (408 μg/g extract), and quercetin (336 μg/g extract) were detected in the methanol extract while rutin (506 μg/g extract) was most abundant in the aqueous extract. As for their biological properties, the methanol extract exhibited the best antioxidant effect in the DPPH and CUPRAC assays, and also the highest inhibition against tyrosinase. The aqueous extract was the least active enzyme inhibitor but showed the highest antioxidant efficacy in the ABTS, FRAP, and metal chelating assays. At a concentration of 15.6 μg/mL, the methanol extract resulted in a moderate decrease (25.1%) of NO production in lipopolysaccharide-stimulated cells. Among the phenolic compounds, epicatechin, (+)-catechin, and kaempferol showed the highest binding affinity towards the studied enzymes in silico. It can be concluded that extracts of S. salsuginea are a potential source of functional food ingredients but need further analytical experiments to explore its complexity of chemical compounds and pharmacological properties as well as using in vivo toxicity models to establish its maximum tolerated dose.
Yazarlar (9)
1
Gokhan Zengin
ORCID: 0000-0001-6548-7823
2
Maria João Rodrigues
3
Hassan H. Abdallah
4
Luisa Custodio
5
Azzurra Stefanucci
6
Muhammad Zakariyyah Aumeeruddy
7
Adriano Mollica
8
Kannan RR Rengasamy
9
Mohamad Fawzi Mahomoodally
Anahtar Kelimeler
Anti-inflammatory
Docking
Enzyme inhibitor
Phenolic profile, antioxidant
Silene salsuginea
Kurumlar
REEF Environmental Consultancy
Puducherry India
Salahaddin University-Erbil
Erbil Iraq
Selçuk Üniversitesi
Selçuklu Turkey
Universidade do Algarve
Faro Portugal
Universiti Sains Malaysia
Minden Malaysia
University of G. d'Annunzio Chieti and Pescara
Chieti Italy
University of Mauritius
Reduit Mauritius
Scimago Dergi (ISSN Eşleşmesi)
Computational Biology and Chemistry
Q2
SJR Skoru0,522
H-Index73
YayıncıElsevier Ltd
ÜlkeUnited Kingdom
Computational Mathematics (Q2)
Organic Chemistry (Q2)
Biochemistry (Q3)
Structural Biology (Q3)
Metrikler
59
Atıf
9
Yazar
5
Anahtar Kelime