Scopus
🔓 Açık Erişim
Chromatographic analyses, in vitro biological activities, and cytotoxicity of cannabis sativa l. Essential oil: A multidisciplinary study
Molecules · Aralık 2018
Makale Bilgileri
DergiMolecules
Yayın TarihiAralık 2018
Cilt / Sayfa23
Scopus ID2-s2.0-85058732675
Erişim🔓 Açık Erişim
Özet
Due to renewed interest in the cultivation and production of Italian Cannabis sativa L., we proposed a multi-methodological approach to explore chemically and biologically both the essential oil and the aromatic water of this plant. We reported the chemical composition in terms of cannabinoid content, volatile component, phenolic and flavonoid pattern, and color characteristics. Then, we demonstrated the ethnopharmacological relevance of this plant cultivated in Italy as a source of antioxidant compounds toward a large panel of enzymes (pancreatic lipase, α-amylase, α-glucosidase, and cholinesterases) and selected clinically relevant, multidrug-sensible, and multidrug-resistant microbial strains (Staphylococcus aureus, Helicobacter pylori, Candida, and Malassezia spp.), evaluating the cytotoxic effects against normal and malignant cell lines. Preliminary in vivo cytotoxicity was also performed on Galleria mellonella larvae. The results corroborate the use of this natural product as a rich source of important biologically active molecules with particular emphasis on the role exerted by naringenin, one of the most important secondary metabolites.
Yazarlar (16)
1
Gokhan Zengin
ORCID: 0000-0001-6548-7823
2
Luigi Menghini
ORCID: 0000-0002-7346-7395
3
Antonella Di Sotto
4
Romina Mancinelli
5
F. Sisto
6
Simone Carradori
7
Stefania Cesa
ORCID: 0000-0002-8649-0017
8
Caterina Fraschetti
9
Antonello Filippi
10
L. Angiolella
11
Marcello Locatelli
ORCID: 0000-0002-0840-825X
12
Luisa Mannina
ORCID: 0000-0001-8659-5890
13
Cinzia Ingallina
ORCID: 0000-0003-4817-7318
14
Valentina Puca
15
Marianna D’antonio
16
R. Grande
Anahtar Kelimeler
Antimicrobial activity
Antioxidant activity
Biofilm
Cancer cell cytotoxicity
Cannabis sativa L
Chromatographic analysis
Essential oil
Galleria mellonella
Naringenin
Kurumlar
Center of Excellence on Aging and Translational Medicine - CeSI-MeT
Chieti Italy
Facoltà di Farmacia e Medicina
Rome Italy
Ospedale S. Spirito
Rome Italy
Sapienza Università di Roma
Rome Italy
Selçuk Üniversitesi
Selçuklu Turkey
Università degli Studi di Milano
Milan Italy
University of G. d'Annunzio Chieti and Pescara
Chieti Italy
Metrikler
121
Atıf
16
Yazar
9
Anahtar Kelime