Scopus
YÖKSİS ISSN Eşleşti
SJR Q1
Volatile components, pharmacological profile, and computational studies of essential oil from Aegle marmelos (Bael) leaves: A functional approach
Industrial Crops and Products · Aralık 2018
YÖKSİS Kayıtları — ISSN Eşleşmesi
A comprehensive study on phytochemical characterization of Haplophyllum myrtifolium Boiss endemic to Turkey and its inhibitory potential against key enzymes involved in Alzheimer skin diseases and type II diabetes
2014 ISSN: 09266690 SCI-Expanded 4 atıf
Prof. Dr. GÖKHAN ZENGİN →
HPLC DAD analysis of phenolic compounds and antioxidant properties of Asphodeline lutea roots from Bulgaria and Turkey
2014 ISSN: 09266690 SCI-Expanded 1 atıf
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Phenolic constituent antioxidative and tyrosinase inhibitory activity of Ornithogalum narbonense L from Turkey A phytochemical study
2015 ISSN: 09266690 SCI-Expanded 1 atıf
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Composition antioxidant antimicrobial and enzyme inhibition activities of two Origanum vulgare subspecies subsp vulgare and subsp hirtum essential oils
2015 ISSN: 09266690 SCI-Expanded
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Changes in the fatty acid compositions and bioactivities of clary sage seeds depending on harvest year
2012 ISSN: 0926-6690 SCI-Expanded
Prof. Dr. ERAY TULUKCU →
A phytochemical study on Potentilla anatolica An endemic Turkish plant
2015 ISSN: 09266690 SCI-Expanded
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
Phenolic constituent antioxidative and tyrosinase inhibitory activity of Ornithogalum narbonense L from Turkey A phytochemical study
2015 ISSN: 09266690 SCI-Expanded
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
Composition antioxidant antimicrobial and enzyme inhibition activities of two Origanum vulgare subspecies subsp vulgare and subsp hirtum essential oils
2015 ISSN: 09266690 SCI-Expanded
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
HPLC DAD analysis of phenolic compounds and antioxidant properties of Asphodeline lutea roots from Bulgaria and Turkey
2014 ISSN: 09266690 SCI-Expanded
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
A comprehensive study on phytochemical characterization of Haplophyllum myrtifolium Boiss endemic to Turkey and its inhibitory potential against key enzymes involved in Alzheimer skin diseases and type II diabetes
2014 ISSN: 09266690 SCI-Expanded
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
Chemical and biological fingerprints of two Fabaceae species Cytisopsis dorycniifolia and Ebenus hirsuta Are they novel sources of natural agents for pharmaceutical and food formulations
2016 ISSN: 09266690 SCI-Expanded
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
A study on in vitro enzyme inhibitory properties of Asphodeline anatolica New sources of natural inhibitors for public health problems
2016 ISSN: 09266690 SCI-Expanded
Prof. Dr. GÖKHAN ZENGİN →
Immunomodulatory properties of various natural compounds and essential oils through modulation of human cellular immune response
2016 ISSN: 09266690 SCI
Prof. Dr. YÜKSEL KAN →
Enzyme inhibitory and antioxidant activities of Nerium oleander L. flower extracts and activity guided isolation of the active components
2018 ISSN: 09266690 SCI-Expanded
Prof. Dr. GÖKHAN ZENGİN →
HPLC–MS/MS-based metabolic profiling and pharmacological properties of extracts and infusion obtained from Amelanchier parviflora var. dentata
2018 ISSN: 0926-6690 SCI-Expanded
Prof. Dr. GÖKHAN ZENGİN →
Enzyme inhibitory and antioxidant activities of Nerium oleander L. flower extracts and activity guided isolation of the active components
2018 ISSN: 0926-6690 SCI-Expanded Q1
Prof. Dr. GÖKHAN ZENGİN →
Bioactivity-guided isolation of cytotoxic secondary metabolites from the roots of Glycyrrhiza glabra and elucidation of their mechanisms of action
2018 ISSN: 0926-6690 SCI-Expanded
Prof. Dr. YÜKSEL KAN →
Lotus aegaeus (Gris.) Boiss and Iberis sempervirens L.: Chemical fingerprints, antioxidant potential, and inhibition activities and docking on key enzymes linked to global health problems
2018 ISSN: 0926-6690 SCI-Expanded
Prof. Dr. GÖKHAN ZENGİN →
Exploring the therapeutic potential and phenolic composition of two Turkish ethnomedicinal plants – Ajuga orientalis L. and Arnebia densiflora (Nordm.) Ledeb.
2018 ISSN: 0926-6690 SCI-Expanded
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
Insight into the biological properties and phytochemical composition of Ballota macrodonta Boiss. et Balansa, — an endemic medicinal plant from Turkey
2018 ISSN: 0926-6690 SCI-Expanded
Prof. Dr. GÖKHAN ZENGİN →
Makale Bilgileri
ISSN09266690
Yayın TarihiAralık 2018
Cilt / Sayfa126 · 13-21
Scopus ID2-s2.0-85054315610
Özet
The increasing therapeutic use of plant essential oil (EO) in aromatherapy has urged scientists to investigate into its biological potency. We report the phytochemical composition of the EO of Aegle marmelos (L.) Corrêa using GC–MS analysis, together with its pharmacological properties (antibacterial, antioxidant, and enzyme inhibitory properties). Molecular docking of the major identified compounds against tyrosinase and α-glucosidase was also performed. The EO displayed the highest total antioxidant potential in the phosphomolybdenum assay (24.70 mmol TE/g sample), but showed mild scavenging (DPPH = 0.03 mmol TE/g sample), and reducing effect (CUPRAC = 0.54 mmol TE/g sample, FRAP = 0.21 mmol TE/g sample). Moreover, the EO of A. marmelos showed the greatest inhibitory property against tyrosinase 53.68 (mg KAE/g sample) and good inhibitory effect on α-glucosidase (39.08 mmol ACAE/g sample) compared with α-amylase (0.19 mmol ACAE/g sample). In addition, the EO exhibited moderate AChE inhibition (2.75 mg GALAE/g sample) and BChE inhibition (4.93 mg GALAE/g sample). Disc diffusion assay revealed that S. aureus (Zone of inhibition (ZOI) = 21.4 mm) was most susceptible to the EO followed by C. diphtheriae (ZOI = 17.2 mm) while the lowest MIC value was observed against B. cereus and C. diphtheriae (MIC = 125 μg/ml). The EO of A. marmelos was abundant in limonene (74.9%) followed by β-phellandrene (4.4%), p-cymene (4.2%), and β-caryophyllene (2.0%). Humulene and cryptone exhibited higher docking score after docking to tyrosinase while the best docking scores observed against α-glucosidase was found for humulene and carveol. The EO of A. marmelos showed promising inhibitory activities against vital enzymes related to diabetes, neurological, and skin disorders, and mild antioxidant ability, thus highlighting the quenching abilities of surplus reactive oxygen species related to these disorders. It is predicted that the results obtained will stimulate further research to probe into the therapeutic properties of A. marmelos.
Yazarlar (6)
1
Mohamad Fawzi Mahomoodally
2
Adriano Mollica
3
Azzurra Stefanucci
4
Muhammad Zakariyyah Aumeeruddy
5
Ramjuttun Poorneeka
6
Gokhan Zengin
ORCID: 0000-0001-6548-7823
Anahtar Kelimeler
Aegle marmelos
Antibacterial, antidiabetic
Antioxidants
Bael
Cholinesterase
GC–MS
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
University of G. d'Annunzio Chieti and Pescara
Chieti Italy
University of Mauritius
Reduit Mauritius
Scimago Dergi (ISSN Eşleşmesi)
Industrial Crops and Products
Q1
SJR Skoru0,974
H-Index186
YayıncıElsevier B.V.
ÜlkeNetherlands
Agronomy and Crop Science (Q1)
Metrikler
67
Atıf
6
Yazar
6
Anahtar Kelime