Scopus
🔓 Açık Erişim
Phytochemical analyses and pharmacological screening of Neem oil
South African Journal of Botany · Ocak 2019
Makale Bilgileri
DergiSouth African Journal of Botany
Yayın TarihiOcak 2019
Cilt / Sayfa120 · 331-337
Scopus ID2-s2.0-85056468212
Erişim🔓 Açık Erişim
Özet
An Italian certified Neem seed oil was characterized through the color analysis, the HPLC phenolic fingerprint and the preliminary evaluation of the cytotoxicity profile against the human macrophage (THP-1) cell line. Moreover, a wide screening of its enzyme inhibitory profile, antimicrobial activity towards Helicobacter pylori, several Candida spp. and Malassezia furfur strains and antiprotozoal activity against Plasmodium falciparum, Leishmania infantum and Leishmania tropica were performed. Neem seed oil demonstrated low toxicity and a great inhibitory efficacy against tyrosinase and lipase enzymes. Antimalarial and anti-leishmanial activities were also demonstrated, but weak or no activity was evidenced against Helicobacter pylori, Candida and Malassezia strains. Overall, these findings encourage the potential use of this natural product in some disease treatments and justify its use in traditional medicine.
Yazarlar (14)
1
Stefania Cesa
ORCID: 0000-0002-8649-0017
2
F. Sisto
3
Gokhan Zengin
ORCID: 0000-0001-6548-7823
4
D. Scaccabarozzi
5
A. K. Kokolakis
6
M. M. Scaltrito
7
R. Grande
8
Marcello Locatelli
ORCID: 0000-0002-0840-825X
9
Francesco Cacciagrano
10
L. Angiolella
11
Cristina Campestre
12
A. Granese
13
Paola Chimenti
14
N. Basilico
Anahtar Kelimeler
Color analysis
Enzyme inhibition
HPLC-PDA
H. pylori
Leishmania
Malaria
Neem oil
Kurumlar
Facoltà di Farmacia e Medicina
Rome Italy
Sapienza Università di Roma
Rome Italy
Selçuk Üniversitesi
Selçuklu Turkey
Università degli Studi di Milano
Milan Italy
University of Crete
Rethymnon Greece
University of G. d'Annunzio Chieti and Pescara
Chieti Italy
Metrikler
25
Atıf
14
Yazar
7
Anahtar Kelime