Scopus
🔓 Açık Erişim
Berberine in cardiovascular and metabolic diseases: From mechanisms to therapeutics
Theranostics · Ocak 2019
Makale Bilgileri
DergiTheranostics
Yayın TarihiOcak 2019
Cilt / Sayfa9 · 1923-1951
Scopus ID2-s2.0-85065480668
Erişim🔓 Açık Erişim
Özet
Cardiovascular and metabolic diseases (CVMD) are the leading causes of death worldwide, underscoring the urgent necessity to develop new pharmacotherapies. Berberine (BBR) is an eminent component of traditional Chinese and Ayurvedic medicine for more than 2000 years. Recently, BBR has attracted much interest for its pharmacological actions in treating and/or managing CVMD. Recent discoveries of basic, translational and clinical studies have identified many novel molecular targets of BBR (such as AMPK, SIRT1, LDLR, PCSK9, and PTP1B) and provided novel evidences supporting the promising therapeutic potential of BBR to combat CVMD. Thus, this review provides a timely overview of the pharmacological properties and therapeutic application of BBR in CVMD, and underlines recent pharmacological advances which validate BBR as a promising lead drug against CVMD.
Yazarlar (18)
1
Xiaojun Feng
2
Antoni Sureda
3
Samineh Jafari
4
Zahra Memariani
5
Devesh Tewari
ORCID: 0000-0002-5125-3791
6
Giuseppe Annunziata
7
Luigi Barrea
8
Sherif T.S. Hassan
9
Karel Šmejkal
10
Milan Malaník
11
Alice Sychrová
12
Davide Barreca
13
Lovro Ziberna
14
Mohamad Fawzi Mahomoodally
15
Gokhan Zengin
ORCID: 0000-0001-6548-7823
16
Suowen Xu
17
Seyed Mohammad Nabavi
18
Ai Zong Shen
Anahtar Kelimeler
Berberine
Cardiovascular diseases
Metabolic diseases
Targets
Therapeutics
Kurumlar
Babol University of Medical Sciences
Babol Iran
Baqiyatallah University of Medical Sciences
Tehran Iran
Instituto de Salud Carlos III
Madrid Spain
Lovely Professional University
Phagwara India
School of Pharmacy, Zanjan University of Medical Sciences (ZUMS)
Zanjan Iran
Selçuk Üniversitesi
Selçuklu Turkey
Università degli Studi di Messina
Messina Italy
Università degli Studi di Napoli Federico II
Naples Italy
University of Mauritius
Reduit Mauritius
University of Rochester School of Medicine and Dentistry
Rochester United States
University of Science and Technology of China
Hefei China
Univerza v Ljubljani
Ljubljana Slovenia
Veterinární Univerzita Brno
Brno Czech Republic
Metrikler
278
Atıf
18
Yazar
5
Anahtar Kelime