Scopus
🔓 Açık Erişim
Alchemilla vulgaris agg. (Lady's mantle) from central Balkan: Antioxidant, anticancer and enzyme inhibition properties
RSC Advances · Ocak 2019
Makale Bilgileri
DergiRSC Advances
Yayın TarihiOcak 2019
Cilt / Sayfa9 · 37474-37483
Scopus ID2-s2.0-85075594901
Erişim🔓 Açık Erişim
Özet
The current study was designed to evaluate the phytochemical profile and biological properties (antioxidant, enzyme inhibitory and cytotoxic activity) of methanolic, ethanolic, ethyl-acetate and water extracts of Alchemilla vulgaris from Southeast Serbia (central Balkan) which was traditionally used to alleviate and treat many diseases. Bioactive compounds were characterized by LC-MS/MS technique and biological properties were evaluated using antioxidant, enzyme inhibitory and cytotoxic assays. Twenty-six phenolic compounds were quantified in methanolic, ethanolic, ethyl acetate and water extracts, whereas the highest yields were found in ethyl-acetate (EA) extract (gallic acid, caffeic acid, catchin, quercetin). This extract has also shown the greatest antioxidant, anticancer and inhibitory enzyme activities which were demonstrated for the first time in this study. The obtained results indicated that Alchemilla vulgaris from South Serbia possesses high potential for pharmaceutical applications.
Yazarlar (7)
1
Sanja Vlaisavljevic
2
Sanja Jelača
3
Gokhan Zengin
ORCID: 0000-0001-6548-7823
4
Neda Mimica-Dukić
5
Sanja Berežni
6
Milorad Miljić
7
Zora Dajić Stevanović
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
University of Belgrade
Belgrade Serbia
University of Novi Sad
Novi Sad Serbia
Metrikler
27
Atıf
7
Yazar