Scopus
YÖKSİS Eşleşti
A comprehensive appraisal on Crocus chrysanthus (Herb.) Herb. flower extracts with HPLC–MS/MS profiles, antioxidant and enzyme inhibitory properties
Journal of Pharmaceutical and Biomedical Analysis · Şubat 2019
YÖKSİS Kayıtları
A comprehensive appraisal on Crocus chrysanthus (Herb.) Herb. flower extracts with HPLC–MS/MS profiles, antioxidant and enzyme inhibitory properties
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS · 2019 SCI-Expanded
PROFESÖR GÖKHAN ZENGİN →
A comprehensive appraisal on Crocus chrysanthus (Herb.) Herb. flower extracts with HPLC–MS/MS profiles, antioxidant and enzyme inhibitory properties
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS · 2019 SCI-Expanded
PROFESÖR EVREN YILDIZTUGAY →
Makale Bilgileri
DergiJournal of Pharmaceutical and Biomedical Analysis
Yayın TarihiŞubat 2019
Cilt / Sayfa164 · 581-589
Scopus ID2-s2.0-85056733063
Özet
In the quest for new drugs of herbal origin, the ethyl acetate (EAE), methanol (ME), and water (WE) extracts of Crocus chrysanthus (Herb.) Herb. flowers were analyzed for their polyphenolic composition, antioxidant, and enzyme inhibitory potential. WE showed the highest antioxidant activities in all assays including metal chelating, phosphomolybdenum, FRAP, CUPRAC, ABTS and DPPH. EAE was the most effective enzyme inhibitor, exhibiting the highest inhibition against some enzymes linked to Alzheimer's disease (cholinesterases), diabetes mellitus (α-glucosidase and α-amylase) and hyperpigmentation problems (tyrosinase). The highest total phenolics (34.99 mg GAE/g) and flavonoids content (77.58 mg RE/g) were observed in WE and ME, respectively. Eight compounds were identified in EAE, 24 in ME, and 15 in WE. Kaempferol 3-O glucoside was found in all extracts. In conclusion, C. chrysanthus flowers can be suggested as a source of bioactive components with potential use against chronic disorders caused by oxidative stress. Future in-depth studies are recommended to determine the biological effects of isolated compounds from C. chrysanthus to identify the main compounds modulating the observed activities.
Yazarlar (8)
1
Gokhan Zengin
ORCID: 0000-0001-6548-7823
2
Muhammad Zakariyyah Aumeeruddy
3
Alina Diuzheva
ORCID: 0000-0003-2090-1634
4
József Jekő
5
Zoltán Cziáky
6
Ayşegül Yildiztugay
ORCID: 0000-0001-6880-1996
7
Evren Yildiztugay
ORCID: 0000-0002-4675-2027
8
Mohamad Fawzi Mahomoodally
Anahtar Kelimeler
Crocus chrysanthus
Enzyme inhibitor
Oxidative stress
Polyphenolic
Kurumlar
Pavol Jozef Šafárik University in Košice
Kosice Slovakia
Selçuk Üniversitesi
Selçuklu Turkey
University of Mauritius
Reduit Mauritius
University of Nyíregyháza
Nyíregyháza Hungary
Metrikler
11
Atıf
8
Yazar
4
Anahtar Kelime