Scopus
YÖKSİS DOI Eşleşti
SJR Q1
Multidirectional biological investigation and phytochemical profile of Rubus sanctus and Rubus ibericus
Food and Chemical Toxicology · Mayıs 2019
YÖKSİS Kayıtları
Multidirectional biological investigation and phytochemical profile of Rubus sanctus and Rubus ibericus
Food and Chemical Toxicology · 2019 SCI-Expanded
Prof. Dr. GÖKHAN ZENGİN →
YÖKSİS Kayıtları — ISSN Eşleşmesi
In vitro antioxidant capacities and fatty acid compositions of three Centaurea species collected from Central Anatolia region of Turkey
2010 ISSN: 02786915 SCI 15 atıf
Prof. Dr. GÖKHAN ZENGİN →
Screening for in vitro antioxidant properties and fatty acid profiles of five Centaurea L species from Turkey flora
2011 ISSN: 02786915 SCI 12 atıf
Prof. Dr. GÖKHAN ZENGİN →
Antioxidant potentials and anticholinesterase activities of methanolic and aqueous extracts of three endemic Centaurea L species
2013 ISSN: 02786915 SCI-Expanded
Prof. Dr. GÖKHAN ZENGİN →
Antioxidant potentials and anticholinesterase activities of methanolic and aqueous extracts of three endemic Centaurea L species
2013 ISSN: 02786915 SCI-Expanded
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
Screening for in vitro antioxidant properties and fatty acid profiles of five Centaurea L species from Turkey flora
2011 ISSN: 02786915 SCI-Expanded
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
In vitro antioxidant capacities and fatty acid compositions of three Centaurea species collected from Central Anatolia region of Turkey
2010 ISSN: 02786915 SCI-Expanded
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
Organochlorine pesticide residues in wheat from Konya region Turkey
2010 ISSN: 02786915 SCI-Expanded
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
Mineral and heavy metal levels of some fruits grown at the roadsides
2010 ISSN: 0278-6915 SCI-Expanded
Öğr. Gör. NESİM DURSUN →
Mineral and heavy metal levels of some fruits grown at the roadsides
2010 ISSN: 0278-6915 SSCI 23 atıf
Prof. Dr. SAİT GEZGİN →
Phytochemical contents and enzyme inhibitory and antioxidant properties of Anethum graveolens L dill samples cultivated under organic and conventional agricultural conditions
2013 ISSN: 0278-6915 SCI-Expanded Q1
Dr. Öğr. Üyesi SADİYE AYŞE ÇELİK →
Biological effects and chemical characterization of Iris schachtii Markgr. extracts: A new source of bioactive constituents
2018 ISSN: 0278-6915 SCI
Dr. Öğr. Üyesi ERDOĞAN GÜNEŞ →
Novel in vitro and in silico insights of the multi-biological activities and chemical composition of Bidens tripartita L.
2018 ISSN: 02786915 SCI
Prof. Dr. GÖKHAN ZENGİN →
Bioactivities of Achillea phrygia and Bupleurum croceum based on the composition of phenolic compounds: In vitro and in silico approaches
2017 ISSN: 02786915 SCI
Prof. Dr. GÖKHAN ZENGİN →
Bioactivities of Achillea phrygia and Bupleurum croceum based on the composition of phenolic compounds: In vitro and in silico approaches
2017 ISSN: 02786915 SCI-Expanded
Prof. Dr. GÖKHAN ZENGİN →
Combining in vitro , in vivo and in silico approaches to evaluate nutraceutical potentials and chemical fingerprints of Moltkia aurea and Moltkia coerulea
2017 ISSN: 02786915 SCI-Expanded
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
Evaluation of antioxidant potential, enzyme inhibition activity and phenolic profile of Lathyrus cicera and Lathyrus digitatus : Potential sources of bioactive compounds for the food industry
2017 ISSN: 02786915 SCI-Expanded
Prof. Dr. GÖKHAN ZENGİN →
Combining in vitro , in vivo and in silico approaches to evaluate nutraceutical potentials and chemical fingerprints of Moltkia aurea and Moltkia coerulea
2017 ISSN: 02786915 SCI
Prof. Dr. GÖKHAN ZENGİN →
UHPLC-QTOF-MS analysis of bioactive constituents from two Romanian Goji (Lycium barbarum L.) berries cultivars and their antioxidant, enzyme inhibitory, and real-time cytotoxicological evaluation
2018 ISSN: 0278-6915 SCI
Prof. Dr. GÖKHAN ZENGİN →
Investigations into the therapeutic potential of Asphodeline liburnica roots: In vitro and in silico biochemical and toxicological perspectives
2018 ISSN: 0278-6915 SCI-Expanded
Prof. Dr. GÖKHAN ZENGİN →
Novel in vitro and in silico insights of the multi-biological activities and chemical composition of Bidens tripartita L.
2018 ISSN: 0278-6915 SCI-Expanded
Prof. Dr. GÖKHAN ZENGİN →
Makale Bilgileri
ISSN02786915
Yayın TarihiMayıs 2019
Cilt / Sayfa127 · 237-250
Scopus ID2-s2.0-85063437653
Özet
In the present study, the biological properties, including, the enzyme inhibitory and antioxidant activities, as well as, the phytochemical profile of the ethyl acetate, methanol, and water extracts of Rubus sanctus Schreb. and Rubus ibericus Juz. leaves were determined using in vitro bioassays. Wide range of phytochemicals, including, hydroxybenzoic acids, hydroxycinnamic acids, acylquinic acids, ellagitannins, flavonoids, and triterpenoid saponins were determined using UHPLC-ESI/HRMS technique. The ethyl acetate and methanol extracts of the studied Rubus species effectively inhibited acetyl and butyryl cholinesterase. On the other hand, R. sanctus water extract showed low inhibition against α-amylase and prominent inhibitory action against α-glucosidase. Data collected from this study reported the radical scavenging and reducing potential of the studied Rubus species. Investigation of the protective effects of the different extracts of R. sanctus and R. ibericus in experimental model of ulcerative colitis was performed. The extracts were also tested on spontaneous migration of human colon cancer cells (HCT116) in wound healing experimental paradigm. Only R. sanctus methanol extract inhibited spontaneous HCT116 migration in the wound healing test. Our results suggested that R. sanctus and R. ibericus may be potential candidates as sources of biologically-active compounds for the development of nutraceuticals, pharmaceuticals, and/or cosmetics.
Yazarlar (14)
1
Gokhan Zengin
ORCID: 0000-0001-6548-7823
2
Claudio Ferrante
3
Ismail Senkardes
4
Reneta Gevrenova
ORCID: 0000-0002-1254-2419
5
Dimitrina Zheleva-Dimitrova
ORCID: 0000-0002-1952-9903
6
Luigi Menghini
ORCID: 0000-0002-7346-7395
7
Giustino Orlando
8
Lucia Recinella
9
Annalisa Chiavaroli
ORCID: 0000-0002-3399-967X
10
Sheila Leone
11
Luigi Brunetti
12
Carene Marie Nancy Picot-Allain
13
Kannan RR Rengasamy
14
Mohamad Fawzi Mahomoodally
Anahtar Kelimeler
Anti-inflammatory
Antioxidant
LC-MS
Rubus
Toxicity
Wound healing
Kurumlar
Konkuk University
Seoul South Korea
Marmara Üniversitesi
Istanbul Turkey
Medical University of Sofia
Sofia Bulgaria
Selçuk Üniversitesi
Selçuklu Turkey
University of G. d'Annunzio Chieti and Pescara
Chieti Italy
University of Mauritius
Reduit Mauritius
Scimago Dergi (ISSN Eşleşmesi)
Food and Chemical Toxicology
Q1
SJR Skoru0,750
H-Index223
YayıncıElsevier Ltd
ÜlkeUnited Kingdom
Food Science (Q1)
Medicine (miscellaneous) (Q2)
Toxicology (Q2)
Metrikler
24
Atıf
14
Yazar
6
Anahtar Kelime