Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Comprehensive chemical profiling and multidirectional biological investigation of two wild anthemis species (Anthemis tinctoria var. Pallida and A. Cretica subsp. Tenuiloba): Focus on neuroprotective effects
Molecules · Temmuz 2019
YÖKSİS Kayıtları
Comprehensive Chemical Profiling and Multidirectional Biological Investigation of Two Wild Anthemis Species (Anthemis tinctoria var. Pallida and A. cretica subsp. tenuiloba): Focus on Neuroprotective Effects
Molecules · 2019 SCI-Expanded
PROFESÖR GÖKHAN ZENGİN →
Makale Bilgileri
DergiMolecules
Yayın TarihiTemmuz 2019
Cilt / Sayfa24
Scopus ID2-s2.0-85069642149
Erişim🔓 Açık Erişim
Özet
Ethyl acetate (EA), methanol (MeOH), and aqueous extracts of aerial parts of Anthemis tinctoria var. pallida (ATP) and A. cretica subsp. tenuiloba (ACT) were investigated for their phenol and flavonoid content, antioxidant, and key enzyme inhibitory potentials. All extracts displayed antiradical effects, with MeOH and aqueous extracts being a superior source of antioxidants. On the other hand, EA and MeOH extracts were potent against AChE and BChE. Enzyme inhibitory effects against tyrosinase and α-glucosidase were observed, as well. We also studied Anthemis extracts in an ex vivo experimental neurotoxicity paradigm. We assayed extract influence on oxidative stress and neurotransmission biomarkers, including lactate dehydrogenase (LDH) and serotonin (5-HT), in isolated rat cortex challenged with K+ 60 mM Krebs-Ringer buffer (excitotoxicity stimulus). An untargeted proteomic analysis was finally performed in order to explore the putative mechanism in the brain. The pharmacological study highlighted the capability of ACT water extract to blunt K+ 60 mM increase in LDH level and 5-HT turnover, and restore physiological activity of specific proteins involved in neuron morphology and neurotransmission, including NEFMs, VAMP-2, and PKCγ, thus further supporting the neuroprotective role of ACT water extract.
Yazarlar (16)
1
Giustino Orlando
2
Gokhan Zengin
ORCID: 0000-0001-6548-7823
3
Claudio Ferrante
4
Maurizio Ronci
5
Lucia Recinella
6
Ismail Senkardes
7
Reneta Gevrenova
ORCID: 0000-0002-1254-2419
8
Dimitrina Zheleva-Dimitrova
ORCID: 0000-0002-1952-9903
9
Annalisa Chiavaroli
ORCID: 0000-0002-3399-967X
10
Sheila Leone
11
Simonetta Cristina Di Simone
ORCID: 0000-0001-5041-3848
12
Luigi Brunetti
13
Carene Marie Nancy Picot-Allain
14
Mohamad Fawzi Mahomoodally
15
Kouadio Ibrahime Sinan
16
Luigi Menghini
ORCID: 0000-0002-7346-7395
Anahtar Kelimeler
Anthemis
Neurotransmission
Oxidative stress
Phytomedicine
Proteomic
Kurumlar
Marmara Üniversitesi
Istanbul Turkey
Medical University of Sofia
Sofia Bulgaria
Selçuk Üniversitesi
Selçuklu Turkey
University of G. d'Annunzio Chieti and Pescara
Chieti Italy
University of Mauritius
Reduit Mauritius
Metrikler
26
Atıf
16
Yazar
5
Anahtar Kelime