Scopus
YÖKSİS DOI Eşleşti
SJR Q2
Biologically active compounds from two members of the Asteraceae family: Tragopogon dubius Scop. and Tussilago farfara L.
Journal of Biomolecular Structure and Dynamics · Ağustos 2019
YÖKSİS Kayıtları
Biologically active compounds from two members of the Asteraceae family: Tragopogon dubius Scop. and Tussilago farfara L.
JOURNAL OF BIOMOLECULAR STRUCTURE DYNAMICS · 2019 SCI
Prof. Dr. GÖKHAN ZENGİN →
Biologically active compounds from two members of the Asteraceae family:Tragopogon dubius Scop. and Tussilago farfara L.
JOURNAL OF BIOMOLECULAR STRUCTURE DYNAMICS · 2018 SCI-Expanded
Prof. Dr. GÖKHAN ZENGİN →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Biologically active compounds from two members of the Asteraceae family:Tragopogon dubius Scop. and Tussilago farfara L.
2018 ISSN: 0739-1102 SCI-Expanded
Prof. Dr. GÖKHAN ZENGİN →
Formation of the Inclusion Complex of Water Soluble Fluorescent Calix[4]arene and Naringenin: Solubility, Cytotoxic effect and Molecular Modeling Studies
2019 ISSN: 0739-1102 SCI
Prof. Dr. MUSTAFA YILMAZ →
Biologically active compounds from two members of the Asteraceae family: Tragopogon dubius Scop. and Tussilago farfara L.
2019 ISSN: 0739-1102 SCI
Prof. Dr. GÖKHAN ZENGİN →
Formation of the inclusion complex of water soluble fluorescent calix[4]arene and naringenin: solubility, cytotoxic effect and molecular modeling studies
2020 ISSN: 0739-1102 SCI-Expanded Q2
Prof. Dr. SERDAR KARAKURT →
Enzyme inhibitory potential of some indole Schiff bases on acetylcholinesterase and human carbonic anhydrase isoforms I and II enzymes: an
in vitro and
molecular docking study
2023 ISSN: 0739-1102 SCI-Expanded Q3
Doç. Dr. HANİF ŞİRİNZADE →
Water-soluble Pillar[5]arene-based drug candidates for lung and breast cancer
2025 ISSN: 0739-1102 SCI-Expanded Q1
Prof. Dr. MUSTAFA ÖZMEN →
Development of a novel apigenin prodrug programmed for alkaline-phosphatase instructed self-inhibition to combat cancer
2023 ISSN: 0739-1102 SCI
Prof. Dr. SERDAR KARAKURT →
Makale Bilgileri
ISSN07391102
Yayın TarihiAğustos 2019
Cilt / Sayfa37 · 3269-3281
Scopus ID2-s2.0-85057342761
Özet
Tragopogon dubius and Tussilago farfara are consumed as vegetables and used in folk medicine to manage common diseases. Herein, the chemical compositions and biological activities of different leaf extracts (ethyl acetate, methanol, and water) of T. dubius and T. farfara were evaluated. The antibacterial, antifungal, and antioxidant abilities of the extracts were tested using different assays including free radical scavenging, reducing power, phosphomolybdenum, and metal chelating assays. Enzyme inhibitory potentials were evaluated against cholinesterases, tyrosinase, α-amylase and α-glucosidase. Complexes of bioactive compounds (chlorogenic and rosmarinic acid) were docked into the enzymatic cavity of α-glucosidase and subjected to molecular dynamic calculation, enzyme conformational stability, and flexibility analysis. T. dubius and T. farfara extracts showed remarkable antioxidant potentials. Ethyl acetate extracts of T. dubius and T. farfara were the most potent inhibitors of acetylcholinesterase and butyrylcholinesterase. T. dubius ethyl acetate extract and T. farfara methanolic extract showed noteworthy activity against α-glucosidase. High performance liquid chromatography analysis revealed the abundance of some phenolic compounds including chlorogenic and rosmarinic acids. Ethyl acetate extract of T. dubius showed notable antifungal activity against all strains. Docking studies showed best pose for chlorogenic acid was stabilized by a network of hydrogen bonds with residues Asp1157, Asp1279, whereas rosmarinic acid showed several hydrogen bonds with Asp1157, Asp1420, Asp1526, Lys1460 and Trp1369. This study further validates the use of T. dubius and T. farfara in traditional medicine, as well as act as a stimulus for further studies for future biomedicine development. Communicated by Ramaswamy H. Sarma.
Yazarlar (10)
1
Sengul Uysal
2
Ismail Senkardes
3
Adriano Mollica
4
Gokhan Zengin
ORCID: 0000-0001-6548-7823
5
Gizem Bulut
6
Ahmet Dogan
7
Jasmina Glamočlija
8
Marina Soković
ORCID: 0000-0002-7381-756X
9
Devina Lobine
10
Mohamad Fawzi Mahomoodally
Anahtar Kelimeler
antioxidant
enzyme inhibition
in silico studies
polyphenols
T. dubius
T. farfara
Kurumlar
Marmara Üniversitesi
Istanbul Turkey
Selçuk Üniversitesi
Selçuklu Turkey
University of Belgrade
Belgrade Serbia
University of G. d'Annunzio Chieti and Pescara
Chieti Italy
University of Mauritius
Reduit Mauritius
Scimago Dergi (ISSN Eşleşmesi)
Journal of Biomolecular Structure and Dynamics
Q2
SJR Skoru0,533
H-Index98
YayıncıTaylor and Francis Ltd.
ÜlkeUnited Kingdom
Medicine (miscellaneous) (Q2)
Molecular Biology (Q3)
Structural Biology (Q3)
Metrikler
41
Atıf
10
Yazar
6
Anahtar Kelime